Challenges in Brain Drug Delivery for Neurodegenerative Disorders and Recent Trends: A Review [0.03%]
药物递送在神经退行性疾病治疗中的挑战及最新趋势综述
Ashif Anjukandan,Rajaganapathy Kaliyaperumal
Ashif Anjukandan
Introduction: Age-related disorders known as neurodegenerative illnesses are defined by uncontrolled neuronal loss that gradually impairs brain function. The majority of age-related neurodegenerative disorders are caused ...
From Microbes to Minds: The Impact of Gut Bacteria on Infant Cognitive Growth [0.03%]
从微生物到思维：肠道细菌对婴儿认知成长的影响
Monireh Rahimkhani,Maryam Hosseini
Monireh Rahimkhani
Recent advances underscore the pivotal role of the gut microbiota in shaping infant brain development, emphasizing how the diversity and function of microbial communities regulate neurodevelopmental processes. This review synthesizes curren...
Ritika Sharma,Avneet Kaur,Sonima Prasad et al.
Ritika Sharma et al.
To explore the neuroprotective mechanisms of terpenoids, including their modulation of inflammation, mitigation of oxidative stress, regulation of apoptotic pathways, and promotion of neurogenesis, a wide variety of naturally occurring chem...
Cognitive Decline in Atherosclerotic Diseases: Mechanisms and Potential Solutions [0.03%]
动脉硬化性疾病的认知功能下降：机制及潜在解决方案
Japleen Kaur,Ram Agrawal,Chidurala Rahul et al.
Japleen Kaur et al.
Atherosclerosis has been increasingly recognized as a contributor to cognitive decline through mechanisms such as cerebral hypoperfusion, oxidative stress, and chronic inflammation. These mechanisms include cerebral hypoperfusion, which lim...
Re-Profiling and Re-purposing of FDA-Approved AntiViral Agents Against Neurological Targets of Memory and Cognition: Molecular Docking and Simulation Approach [0.03%]
基于分子对接和模拟的FDA批准抗病毒药物针对神经元记忆和认知靶点再定位及重利用研究
Mujeeb Ul Naeem,Yousaf Khan,Renato Araújo da Costa et al.
Mujeeb Ul Naeem et al.
Background: Dementia is a prevalent symptom of Alzheimer's Disease (AD), associated with either low levels of acetylcholine or destruction by enzymes. Such enzymes are acetylcholinesterase (AChE) and butyryl-cholinesteras...
Research Progress on Intervention Strategies Targeting the Gut-Brain Axis in Alzheimer`s Disease [0.03%]
针对阿尔茨海默病的脑肠轴干预策略研究进展
Boyuan Xia,Shijing Wu,Weihua Yu et al.
Boyuan Xia et al.
As the most common neurodegenerative disease in the world, Alzheimer's Disease (AD) is characterized by a complex pathogenesis and a lack of effective treatments. In recent years, breakthroughs in the Gut-Brain Axis (GBA) theory have provid...
Synthetic Imidazole Derivatives as Multitarget Agents in Depression: Insights into Mechanism and Therapeutic Promise [0.03%]
合成咪唑衍生物作为抑郁症的多靶点药物：机制和治疗潜力的见解
Shrutika G Kulat,Kalyani Thombre,Krishna Radheshyam Gupta et al.
Shrutika G Kulat et al.
Depression is a complex neuropsychiatric disorder and one of the chief causes of disability in the world. It is also associated with many patients having poor symptom relief under pharmacological treatments, as well as delayed response and ...
Brigatinib in ALK-fused, Low-grade Pediatric Angiocentric Glioma with Multiple Extracranial Metastases: A Case Report [0.03%]
brigatinib在ALK融合、低级别儿童血管中心性胶质瘤伴有多处颅外转移中的应用：1例报告
Tao Liu,Ge Shen,Xiaoyan Zhou et al.
Tao Liu et al.
Background: Gliomas are the most frequent Central Nervous System (CNS) tumors in children and adolescents. Angiocentric glioma is a rare subtype of pediatric-type diffuse low-- grade gliomas with a relatively favorable pr...
Immunoregulatory Effect of Curcumin on Experimental Autoimmune Encephalomyelitis (EAE), an Animal Model of Multiple Sclerosis (MS) [0.03%]
姜黄素对自身免疫性脑脊髓炎的免疫调节作用
Mahshid Sadat Ghafelehbashiha,Behrouz Robat-Jazi,Negar Zand Miralvand et al.
Mahshid Sadat Ghafelehbashiha et al.
Demyelination and progressive neurodegeneration within the central nervous system (CNS) are hallmarks of multiple sclerosis (MS), a chronic autoimmune disease. This review critically assesses the therapeutic efficacy of curcumin-a polypheno...
Parthenolide: Unlocking the Multitarget Molecular Regulatory Network of Neurological Diseases [0.03%]
脱氧阿魏酸：解锁神经疾病多靶点分子调控网络
Yifan Jiang,Xiaoyu Zhang,Yiyang Sun et al.
Yifan Jiang et al.
Introduction: Neurological diseases with a complex etiology and diagnostic complexities are one of the major causes of disability and death globally. In previous preclinical studies, it has been shown that parthenolide (P...