Fan Yang,Zhangfan Zhu,Yongqing Wang et al.
Fan Yang et al.
Cognitive dysfunction, characterized by memory impairment, attentional deficits, and executive dysfunction, represents a critical clinical manifestation in post-acute sequelae of COVID-19 that significantly compromises patients' quality of ...
Differential Effects of Nicotinic, Glutamatergic, and Conventional Wakefulness Agents on Cognition on a Murine Model of Acute Severe Sleep Deprivation [0.03%]
胆碱能、谷氨酸能和传统清醒度药物对急性重度睡眠剥夺小鼠认知的差异化影响
Muhammed Cihan Güvel,Utku Aykan,Gökçen Paykal et al.
Muhammed Cihan Güvel et al.
Objective: Sleep deprivation poses critical safety risks in high-stakes professions, where traditional stimulants often fail to sustain cognitive performance. Addressing the need for novel cognitive enhancers, this study ...
Fisetin and Neurodegeneration: From Preclinical Studies to Potential Clinical Applications [0.03%]
山奈酚与神经退行性病变：从临床前研究到潜在的临床应用
Md Al Amin,Mehrukh Zehravi,Sherouk Hussein Sweilam et al.
Md Al Amin et al.
Neurodegenerative diseases (NDs), like Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis, pose significant challenges due to their gradual deterioration and limited availab...
KCNQ2 Channel as a Druggable Epilepsy Target: Advances in Pharmacological Modifiers [0.03%]
KCNQ2通道作为可用药的癫痫靶点：药理学修饰剂的研究进展
Inn-Chi Lee,Shi-Bing Yang,Swee-Hee Wong et al.
Inn-Chi Lee et al.
KCNQ2 encodes the Kv7.2 channel, which mediates the M-current and regulates neuronal excitability. Pathogenic variants of KCNQ2 are associated with a spectrum of neonatal epilepsies, ranging from self-limited familial neonatal epilepsy to s...
The Effect of a Novel Antibody-based Drug, Prospekta, on Brain Electrical Activity in Mice [0.03%]
新型抗体药物Prospekta对小鼠脑电活动的影响
Elena Kardash,Marina Kabirova,Denis Gorobets et al.
Elena Kardash et al.
Background and objective: An affinity-purified antibody to the calcium-binding protein S100B that has undergone gradual technological processing and was additionally modified with an electromagnetic signal is an active ph...
Nanoformulations: A Progressive Strategy for Alleviating Migraine through Nasal Route [0.03%]
纳米配方：通过鼻腔途径缓解偏头痛的策略
Avinash Tekade,Snehal Kharade,Aliya Anjum Shaikh et al.
Avinash Tekade et al.
Introduction: Migraine is a chronic neurological disorder that can significantly interfere with day-to-day functioning. Currently, migraine is treated with various drugs administered via oral or parenteral routes; however...
MicroRNAs as Molecular Modulators in Stroke: Pathogenic Mechanisms and Therapeutic Avenues [0.03%]
微小核糖核酸在卒中中的分子调控机制及治疗潜力：发病机制和治疗途径研究
Hanshika Yadav,Brahma Nand Jha,Anamika Kumari et al.
Hanshika Yadav et al.
Background: MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression and play crucial roles in various biological processes. Their potential as tools for disease diagnosis, prognosis, and thera...
Understanding Huntington's Disease: Epidemiology, Mechanisms, and Modeling Approaches [0.03%]
解读亨廷顿舞蹈症：流行病学、发病机制及模型研究
Satya Prakash,Neha Kumari,Lovedeep Singh et al.
Satya Prakash et al.
Huntington's disease (HD) is a monogenic, autosomal dominant neurodegenerative disorder. Huntington's disease is caused by a CAG trinucleotide repeat expansion in exon 1 of the huntingtin gene, which is located on the short arm of chromosom...
Redefining Parkinson's Care: The Promise of Nanotechnology and Artificial Intelligence [0.03%]
帕金森病护理的重塑：纳米技术与人工智能的前景
Yagya Dadhich,Saumya Das,Avijit Mazumder
Yagya Dadhich
Introduction: Parkinson's Disease (PD) is a progressive neurodegenerative disorder characterized by the depletion of dopaminergic neurons and the buildup of α-synuclein aggregates, resulting in damaging motor and non-mot...
Neuroinflammatory and Synaptic Roles of Glial Cells in Autism Spectrum Disorder [0.03%]
自闭症谱系障碍中胶质细胞的神经炎症和突触作用
Tavleen Kaur,Dushyant,Neha Yadav et al.
Tavleen Kaur et al.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social communication and repetitive behavior. Early indicators are that glial cells-astrocytes, microglia, and oligodendrocytes-are at the center of t...