Merging Transport Data for Choroid Plexus with Blood-Brain Barrier to Model CNS Homeostasis and Disease More Effectively [0.03%]
将脉络丛与血脑屏障的转运数据合并，更有效地构建中枢神经系统稳态和疾病模型
Conrad Johanson,Nancy Johanson
Conrad Johanson
Robust modeling of CNS transport integrates molecular fluxes at the microvascular blood-brain barrier and epithelial choroid plexus blood-cerebrospinal fluid (CSF) barrier. Normal activity of solute transporters, channels and aquaporins, in...
Hannelore Bauer,Andreas Traweger
Hannelore Bauer
A tight regulation of the neuroparenchymal microenvironment is imperative for proper neurological function. The flux of blood-borne ions and solutes is restricted by specialized tissue barriers and of the three main central nervous system b...
Dan-Yang Tang,Wei-Jiang Zhao
Dan-Yang Tang
Spinal cord injury (SCI) is a long-lasting damage in the spinal cord that leads to paraparesis, paraplegia, quadriplegia and other lifetime disabilities. The underlying mechanisms responsible for the failure of axonal regeneration after SCI...
Curcumin Suppresses Tumor Growth and Angiogenesis in Human Glioma Cells Through Modulation of Vascular Endothelial Growth Factor/ Angiopoietin-2/Thrombospondin-1 Signaling [0.03%]
姜黄素通过调节血管内皮生长因子/血管生成素-2/血小板反应蛋白-1信号转导抑制人类胶质瘤细胞的肿瘤生长和新生血管形成
Zhiqiang Zhang,Cong Li,Qijia Tan et al.
Zhiqiang Zhang et al.
Purpose: To investigate the effect of curcumin on tumor growth and angiogenesis of human gliomas and identify the underlying molecular mechanisms. Methods...
Pathophysiology of Blood-Brain Barrier in Brain Injury in Cold and Hot Environments: Novel Drug Targets for Neuroprotection [0.03%]
冷热环境下脑损伤的血脑屏障病理生理学：神经保护的新药靶点
Hari Shanker Sharma,Dafin F Muresanu,José V Lafuente et al.
Hari Shanker Sharma et al.
The blood-brain barrier (BBB) plays a pivotal role in the maintenance of central nervous system function in health and disease. Thus, in almost all neurodegenerative, traumatic or metabolic insults BBB breakdown occurs, allowing entry of se...
S100A9 Exacerbates the Aβ1-42-mediated Innate Immunity in Human THP-1 Monocytes [0.03%]
S100A9加重人THP-1单核细胞介导的Aβ1-42免疫反应
Kyoung A Jhang,Eun Ok Lee,Hee-Sun Kim et al.
Kyoung A Jhang et al.
The S100A9 protein is an important proinflammatory factor of innate immunity that has been proposed to participate in inflammation associated with the pathogenesis of Alzheimer's disease. Here, we provide insights into the potential roles o...
Soluble Neuregulin-1 from Microglia Enhances Amyloid Beta-induced Neuronal Death [0.03%]
小胶质细胞的可溶性神经调节蛋白-1增强淀粉样β肽所致的神经元死亡
Hyunjeong Liew,Yun-Mi Kim,Hee Soon Choi et al.
Hyunjeong Liew et al.
Neuregulin-1 (NRG-1) is a ligand of the epidermal growth factor receptor (erbB), and its interaction involves activation of the glutamatergic N-methyl-Daspartate receptor, which increases the expression of the β2 subunit of the γ- aminobu...
Hypothalamic AMP-activated Protein Kinase as a Regulator of Food Intake and Energy Balance [0.03%]
作为调节摄食和能量平衡的下丘脑AMP活化蛋白激酶
Tae Seok Oh,Yoonjeong Jeon,Seolsong Kim et al.
Tae Seok Oh et al.
The maintenance of appetite at proper levels, depending on the energy status, is important; otherwise abnormal appetite may cause a series of disorders, such as anorexia, hyperphagia, obesity, and its complications (diabetes mellitus, hyper...
Inês do Carmo G Gonçalves,Wiebke A Rehorst,Min Jeong Kye
Inês do Carmo G Gonçalves
Recent findings indicate an important role for RNA-mediated gene expression in motor neuron diseases, including ALS (amyotrophic lateral sclerosis) and SMA (spinal muscular atrophy). ALS, also known as Lou Gehrig's disease, is an adult-onse...
Dehydroevodiamine•HCl Protects Against Memory Impairment and Cerebral Amyloid-β Production in Tg2576 Mice by Acting as a β-Secretase Inhibitor [0.03%]
盐酸去汉防风碱通过作用于β-分泌酶抑制记忆损伤和脑内淀粉样蛋白-β的产生保护唐氏小鼠(Tg2576)
Ki Young Shin,Su-Jin Noh,Cheol Hyoung Park et al.
Ki Young Shin et al.
We previously demonstrated that dehydroevodiamine•HCl (DHED), which was purified from Evodia rutaecarpa Bentham (Rutaceae), has beneficial effects on memory impairment and neuronal damage in three disease models. To investigate the prevent...