Neurosteroids in Neurological and Psychiatric Disorders: Therapeutic Implications [0.03%]
神经甾体在神经系统疾病和精神疾病治疗中的应用：治疗意义
Keya Mallick,Ritika Ruwatia,Amal C Mondal et al.
Keya Mallick et al.
Neurosteroids play a significant role in brain functions with substantial implications for mood regulation, seizure susceptibility, stress response, and potential therapeutic applications. However, dysregulation of steroidogenesis and its s...
IL-33 is Required for Behavioral Deficits in a Murine Model of Systemic Lupus Erythematosus Through Regulation of Microglia Glycolysis [0.03%]
通过调节小胶质细胞糖酵解，白介素33在系统性红斑狼疮行为缺陷小鼠模型中是必需的
Xiujiao Wang,Fengyun Lu,Mei Sun et al.
Xiujiao Wang et al.
Introduction: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a severe and complex manifestation of SLE. The pathogenesis of diffuse NPSLE (dNPSLE)-which encompasses cognitive dysfunction, mood disorders, psychos...
Molecular Docking and Dynamics-Based Repurposing of Thalidomide and Lenalidomide for GSK-3β Inhibition in AD [0.03%]
基于分子对接和动力学的老药新用：地西他滨和来那度胺通过抑制AD中的GSK-3β起作用
Siddharth Goswami,Shiva Prasad Kollur,Arunima Nayak et al.
Siddharth Goswami et al.
Introduction: Glycogen synthase kinase-3 beta (GSK-3β) is a key serine/threonine protein kinase involved in several neural processes. Its overactivity contributes to the pathogenesis of Alzheimer's disease (AD) through t...
Epilepsy: Modern Treatment Approaches, Clinical Aspects, and Patent Status [0.03%]
癫痫的现代治疗途径、临床方面及专利状况
Anchal Tyagi,Alok Pratap Singh
Anchal Tyagi
Epilepsy is a chronic neurological disorder causing recurrent seizures. Improved diagnosis and management, including high-resolution imaging, genetic testing, and newer antiepileptic drugs with better efficacy and fewer side effects, have e...
Neuroprotective Marine Bioactives in Paediatric ADHD: A Focused Review on Therapeutic Potential [0.03%]
儿童注意缺陷多动障碍的神经保护性海洋生物活性物质：针对治疗潜力的专题回顾
Benu Chaudhary,Preeti Arya,Praveen Kumar et al.
Benu Chaudhary et al.
Introduction: Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental condition in children, marked by symptoms of inattention, hyperactivity, and impulsivity. This review examines the potential of ...
Insights into the Molecular Mechanisms of Neurodegenerative Diseases: Exploring Molecular Pathways and the Therapeutic Potential of Rivastigmine [0.03%]
神经退行性疾病分子机制研究：毒扁豆碱的治疗潜力及作用机制探究
Kuldeep Singh,Pranshul Sethi,Mamta Kumari et al.
Kuldeep Singh et al.
Neurodegenerative diseases are characterized by the progressive loss of neuronal function and structure, often leading to motor and cognitive impairments. The intricate molecular mechanisms underlying these diseases involve key pathways suc...
Hesperetin Early Intervention Reduces Β-Amyloid Production in APP/PS1 Mice by Decreasing Beta and Gamma-Secretase Enzyme [0.03%]
黄酮类化合物hesperetin通过减少β-分泌酶和γ-分泌酶的活性降低APP / PS1小鼠中aβ淀粉样蛋白的产生
Hao Wen,Yifeng Dong,Ruiting Wang
Hao Wen
Introduction: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by β-amyloid (Aβ) plaque accumulation and cognitive decline. Early intervention targeting Aβ production may mitigate AD progression. This study investig...
Enzymatic Biomarkers for Early Diagnosis of Alzheimer's Disease: Uncovering Key Targets and Mechanisms [0.03%]
阿尔茨海默病早期诊断的酶学生物标志物研究：揭示关键靶点与机制
Abhishek Dewangan,Shouvik Kumar Nandy,Anik Kumar Das et al.
Abhishek Dewangan et al.
Alzheimer's Disease (AD) is a neuronal illness that disrupts behavior, cognitive, and functional abilities. The development of AD is progressive, continuous, and irreversible, from preclinical illness to mild cognitive or even behavioral di...
Putative Antianxiety Property of Oral Enalapril Formulation in Mice: a Preclinical and in silico Study [0.03%]
一项关于口服恩拉普利抗焦虑特性的药理和计算研究
Alberto Souza Sá Filho,Rafael Fernandes Costa,Emanuelly Karla Araújo Padilha et al.
Alberto Souza Sá Filho et al.
Introduction: Anxiety disorders, characterized by overwhelming fear, affect more than 30% of the global population. Recent evidence indicates that antihypertensive medications could offer symptomatic relief for anxiety, s...
Nicotine Dependence-Induced Withdrawal Syndrome: Mechanistic Insights and Therapeutic Implications [0.03%]
尼古丁依赖性戒断综合征：机制见解和治疗意义
Heena Khan,Annu Bangar,Aastha Sharma et al.
Heena Khan et al.
Tobacco consumption is a worldwide issue that has significant health repercussions. Each year, related diseases result in an expenditure of billions of dollars in healthcare costs and diminished productivity. People are becoming more consci...