Exploring the role of the CCAAT-binding complex in cell wall maintenance and biofilm formation in Candida albicans [0.03%]
探究CCAAT结合复合物在白色念珠菌细胞壁维持和生物被膜形成中的作用
Dinh-Dong Le,Wen-Han Wang,Chung-Yu Lan
Dinh-Dong Le
Background: The conserved CCAAT-binding complex (CBC) specifically recognizes and binds to the CCAAT motif present in eukaryotic promoters, thereby controlling gene transcription. In Candida albicans, the CBC cooperates w...
Bloodstream infections in hospitalized adults with COVID-19: clinical characteristics and outcomes [0.03%]
新冠肺炎住院成人并发血流感染的临床特征及预后分析
Po-Hsuan Tseng,Ling-Shan Syue,Ching-Chi Lee et al.
Po-Hsuan Tseng et al.
Background: Bloodstream infections (BSIs) are serious complications in hospitalized coronavirus disease 2019 (COVID-19) patients and may have worsened clinical outcomes. We evaluated clinical characteristics and outcomes ...
High-dose daptomycin versus linezolid for the treatment of vancomycin-resistant Enterococcus faecium bloodstream infections: Role of pharmacodynamic target attainment [0.03%]
达托霉素与利奈唑胺治疗耐万古霉素肠球菌败血症的疗效：药动学靶标达标情况的作用
Liang-En Hwang,Jia-Ling Yang,Chi-Ying Lin et al.
Liang-En Hwang et al.
Background: Although high-dose daptomycin (≥8 mg/kg) and linezolid are recommended treatments for vancomycin-resistant Enterococci (VRE) bloodstream infection (BSI), direct comparisons and the impact of achieving prespec...
High prevalence but low clinical impact of acyclovir-resistant herpes simplex virus type 1 infections in patients with hematologic disorders [0.03%]
血液病患者中耐阿昔洛韦单纯疱疹病毒1型感染的高发生率及低临床影响
Chih-Hao Chen,Ling-Ling Chen,Mei-Chi Su et al.
Chih-Hao Chen et al.
Background/purpose: Herpes simplex virus type 1 (HSV-1) is highly prevalent in immunocompromised patients. Due to the recurrent nature of HSV-1 infection, frequent exposure to antiviral agents raises concerns about drug r...
NADPH Oxidase 4 Deficiency Enhances Dendritic Cell-mediated IL-12 Production and Th1 Responses in Mycobacterium tuberculosis Infection [0.03%]
缺损的NADPH氧化酶4增强了分枝杆菌感染中树突状细胞介导的IL-12产生和Th1应答
Seunghyun Lee,Hongmin Kim,Yura Ha et al.
Seunghyun Lee et al.
Background: Mycobacterium tuberculosis (Mtb) infection triggers oxidative stress, necessitating host mechanisms to maintain redox balance. The NADPH oxidase (NOX) family, which produces reactive oxygen species, plays an i...
Genomic analysis of Mycobacterium abscessus isolates from non-cystic fibrosis patients in Thailand: phylogeny, subspecies distribution, and antimicrobial resistance profiles [0.03%]
来源于泰国非囊性纤维化患者的鸟分枝杆菌脓肿亚种菌株的基因组分析：系统发育、亚种分布及抗菌药物耐药谱型
Ajala Prommi,Vorthon Sawaswong,Suthidee Petsong et al.
Ajala Prommi et al.
Background: Mycobacterium abscessus (MABS) is a clinically significant nontuberculous mycobacterium, and its drug resistance poses substantial therapeutic challenges. Comprehensive genomic and phenotypic analyses are esse...
Clinical and genomic insights into Acinetobacter parvus: A rare pathogen with low antibiotic resistance and potential clinical implications [0.03%]
从临床和基因组学角度解析一种罕见且低耐药的条件致病菌阿克托宁分歧杆菌及其潜在临床意义
Qin Tang,Daili Zhou,Fei Yan et al.
Qin Tang et al.
Research background: Traditionally seen as an environmental bacterium, Acinetobacter parvus has rarely been studied in clinical settings. Its role in human infections remains unclear, particularly in vulnerable population...
Active drug-safety monitoring and management in the treatment of rifampicin-resistant tuberculosis: a nationwide multicenter prospective study [0.03%]
利福平耐药结核病治疗中活性药物安全性监测及管理的全国多中心前瞻性研究
Chou-Jui Lin,Chih-Bin Lin,Shun-Tien Chien et al.
Chou-Jui Lin et al.
Background: Active tuberculosis drug-safety monitoring and management (aDSM) is recommended in the treatment of rifampicin-resistant tuberculosis. We established comprehensive aDSM and conducted a nationwide multicenter p...
Components of cardiometabolic risk factors predict liver-related events in patients cured of hepatitis C Virus [0.03%]
心血管风险因素预测丙型肝炎治愈患者的肝脏事件
Wei-Fan Hsu,Hsueh-Chou Lai,Hung-Wei Wang et al.
Wei-Fan Hsu et al.
Background: The new nomenclature of steatotic liver disease (SLD) was proposed in June 2023. The effects of cardiometabolic risk factors (CMRFs) on liver-related events (LREs) in patients achieving chronic hepatitis C (CH...
Taiwan's first successfully treated case of Candida auris-related bilateral leg complicated skin and soft tissue infection, osteomyelitis, and suspected endophthalmitis [0.03%]
台湾首例耳念珠菌所致双下肢复杂皮肤及软组织感染、骨髓炎及疑似眼内炎成功治愈病例报告
Yea-Yuan Chang,Chia-Wei Chang,Yung-Chen Chien et al.
Yea-Yuan Chang et al.