Single-cell transcriptomic analyses of HSV-1 reactivation from latently infected tree shrew and mouse trigeminal ganglia reveal differing molecular and cellular processes [0.03%]
单细胞转录组分析揭示了来自隐性感染树鼩和小鼠三叉神经节中HSV-1再活化存在不同的分子和细胞过程
Yunshuang Ye,Erlin Wang,Mengqiu Yin et al.
Yunshuang Ye et al.
Herpes simplex virus type 1 (HSV-1) infects over 70% of the population and establishes lifelong latent infection with periodic reactivation in humans, resulting in various related diseases. However, the molecular and cellular events underly...
Evidence of human exposure to tick-borne viruses based on viromes of ticks and presence of specific antibodies among patients in Hainan Island, Southern China [0.03%]
基于海南岛蜱病毒组及患者血清中特异性抗体的检测结果证明人感染蜱传病毒的风险性
You Zhang,Yuan Bai,Jun Ni et al.
You Zhang et al.
Hainan Island, located in the South China Sea, is known as an area with diseases related to Rickettsia spp. or spirochete infection; however, the potential threat there from infection with tick-borne viruses (TBVs) remains obscure. In the p...
Desmoglein 2 (DSG2)-knockout human respiratory epithelial cell model to study species B adenovirus receptor usage [0.03%]
用于研究B型腺病毒受体使用的脱鳞蛋白2(DSG2)基因敲除的人呼吸上皮细胞模型
Nora Bahlmann,Montaha Alshawabkeh,Raphael Tsoukas et al.
Nora Bahlmann et al.
With an increasing number of human adenoviruses identified, the selection of potential therapeutic vectors broadens. For safety reasons, achieving cell-specific gene delivery is crucial to minimize off-target effects. Therefore, it is essen...
Advances in human respiratory organoid models for studying the pathogenesis and intervention strategies of COVID-19 [0.03%]
人呼吸道类器官模型研究新冠肺炎发病机制与干预策略的进展
Zeping Shan,Jiarui Li,Zihui Ye et al.
Zeping Shan et al.
Coronavirus Disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), affects multiple organ systems, with the respiratory system being the primary target. Respiratory organoids, which closely mimi...
Integrated multiplex PCR and metatranscriptomics reveal upper-lower airway microbial landscapes in pediatric respiratory infections [0.03%]
整合型多重PCR及元转录组学揭示了儿童呼吸道感染中上下气道的微生物分布特征
Peilan Wei,Lu Zhang,Qingtao Hu et al.
Peilan Wei et al.
Despite widespread use of multiple PCR, a substantial proportion of pediatric acute respiratory tract infections (ARTIs) lack identifiable pathogens and are classified as unknown etiology. The microbial characteristics and clinical relevanc...
Yuxuan Li,Chenxi Zhu,Yi Wang et al.
Yuxuan Li et al.
Influenza virus infections cause significant illness or death every year, becoming a serious health risk. Currently, influenza vaccines mainly induce responses to antibodies against specific strains, but they do not effectively induce effec...
Nuclear translocation of Sp100A suppresses multiple DNA viruses and limits HSV-1 lytic replication in vivo [0.03%]
Sp100A的核转位能够抑制多种DNA病毒并在体内限制HSV-1的溶细胞性复制
Yilei Ma,Weidong Li,Jialing Li et al.
Yilei Ma et al.
Sp100 (Speckled protein 100 kDa), a key component of promyelocytic leukemia (PML) nuclear bodies, plays a pivotal role in intrinsic and innate immunity. The predominant isoform, Sp100A, has been shown by our previous studies to shuttle betw...
GP38 is a structural component of Crimean-Congo hemorrhagic fever virus particles [0.03%]
GP38是克里米亚-刚果出血热病毒颗粒的结构成分
Heya Na,Guibo Rao,Lu Peng et al.
Heya Na et al.
Development of a stable replicon system of a pangolin merbecovirus for antiviral screening [0.03%]
用于抗病毒筛查的穿山甲Merbecovirus稳定复制子系统的开发
Chun-Guang Wu,Jian-Hua Wang,Bo Zhu et al.
Chun-Guang Wu et al.
Genomic Evidence of HMPV Resurgence in Beijing: Clade B2 Triggers the 2024 Winter Epidemic Peak [0.03%]
北京基因组证据显示HMPV卷土重来：谱系B2引发2024年冬季疫情高峰
Lu Kang,Fang Huang,Yi-Mo Deng et al.
Lu Kang et al.
With an unexpected increase of human metapneumovirus (hMPV) cases in northern China since late 2024, concerns arose whether novel hMPV variants triggered this epidemic. Utilizing the Beijing Respiratory Pathogen Surveillance System (RPSS), ...