Immune profile and mitochondrial alterations driven by age and HIV infection: associations with T-cell senescence in people with HIV receiving suppressive antiretroviral therapy [0.03%]
年龄和HIV感染驱动的免疫谱型和线粒体改变及其与接受高效抗逆转录病毒治疗者的HIV感染者T细胞衰老的关系
Junyan Jin,Xin Zhang,Qianqian Xu et al.
Junyan Jin et al.
Antiretroviral therapy (ART) has significantly extended the life expectancy of people with HIV (PWH), rendering population ageing and immunosenescence prominent clinical priorities. T-cell senescence is linked to mitochondrial dysfunction a...
Age-related pharyngeal microbiome and host transcriptomic signatures underlying fever responses in RSV bronchiolitis [0.03%]
与RSV支气管炎发热反应相关的年龄相关咽部微生物组和宿主转录组标志物
Ying Li,Jingyuan Zhang,Haizhou Liu et al.
Ying Li et al.
Respiratory syncytial virus (RSV) bronchiolitis is the leading cause of hospitalization in infancy and exhibits pronounced age-dependent clinical heterogeneity. Fever becomes increasingly prevalent with age, yet whether febrile representati...
HVT-based multiepitope vaccine administered subcutaneously or in ovo boosts protection of inactivated H9N2 vaccine against heterologous virus [0.03%]
基于HVT的多抗原亚单位疫苗肌注或胚内注射可增强灭活H9N2疫苗对异源病毒的保护效力
Zimin Xie,Yingyi Chen,Shanyao Du et al.
Zimin Xie et al.
H9N2 avian influenza virus (AIV) poses a persistent threat as inactivated vaccines (InV) often fail to prevent viral shedding. To address this, we developed a recombinant turkey herpesvirus (HVT-BNT) expressing conserved B and T cell epitop...
STING1 negatively regulates translation and replication of foot-and-mouth disease virus independently of interferon and is antagonized by the viral proteins 3C and 2B [0.03%]
STING1独立于干扰素负向调节 Foot-and-Mouth Disease Virus 的翻译和复制，且被病毒蛋白3C和2B抑制
Wenhua Shao,Wei Zhang,Zhitong Chen et al.
Wenhua Shao et al.
Foot-and-mouth disease virus (FMDV), a highly contagious picornavirus, employs multifaceted strategies to evade host innate immunity, with viral proteins 3C protease (3Cpro) and 2 B serving as key immune antagonists. The stimulator of inter...
A natural five-amino-acid insert at the S2' cleavage site of MERS-CoV spike enhances viral membrane fusion [0.03%]
MERS-CoV刺突蛋白S2'切割位点的天然五氨基酸插入增强病毒膜融合
Guimin Dai,Wenjie Chen,Wenying Cao et al.
Guimin Dai et al.
Generation of G9 genotype porcine rotavirus using reverse genetics system and its application for antiviral screen and vaccine development [0.03%]
基于反向遗传操作的G9基因型猪轮状病毒重建及抗病毒筛选和疫苗研制中的应用研究
Nan Han,Ran Tao,Xi Cheng et al.
Nan Han et al.
Group A rotaviruses (RVs) continue to be one of the most important pathogens causing severe acute gastroenteritis in infants and young animals worldwide. Recently, the prevalence of porcine RV (PoRV) from pig farms has strikingly increased,...
A semi-replicating VSV (srVSV)-based platform for developing broad-spectrum mucosal vaccines against influenza A viruses [0.03%]
一种广谱粘膜流感病毒疫苗开发平台：基于半复制型VSV(srVSV)的疫苗系统
Xianmiao Ye,Junnan Lu,Zirong Han et al.
Xianmiao Ye et al.
Influenza A viruses (IAVs) are significant respiratory pathogens characterized by high mutation rates and frequent genetic reassortments, underscoring the need for vaccines that can induce robust and broadly protective mucosal immunity. Whi...
Identification and characterization of a novel ulcerative enteritis-associated adenovirus of quail causing cross-species infection in chickens [0.03%]
识别并表征一种新型溃疡性肠炎相关鹌鹑腺病毒可感染鸡属宿主交叉种感染
Hui Tang,Yin Shi,Qing Zhang et al.
Hui Tang et al.
Nanobody targeting glycan cap confers broad orthoebolavirus neutralization [0.03%]
靶向糖帽的纳米抗体可提供广谱正粘病毒中和作用
Xinhui Zhang,Yi Liao,Xiuying Liu et al.
Xinhui Zhang et al.
The Zaire Ebola virus (EBOV) and Bundibugyo virus (BDBV) cause severe hemorrhagic fever with high mortality, highlighting the urgent need for broad-spectrum antiviral therapies. Neutralizing nanobodies, with their small size, structural sta...
Establishment of severe in vitro and in vivo infection models for coxsackievirus B4 and their application in identifying viral virulence determinants [0.03%]
柯萨奇病毒B4强毒力感染模型的建立及其在病毒致病因子鉴定中的应用研究
Haoyi Liu,Xianglin Xuan,Bizhen Tang et al.
Haoyi Liu et al.
Coxsackievirus B4 (CVB4) is a highly pathogenic enterovirus associated with severe neurological disease and mortality. To establish research models that recapitulate severe CVB4 infection, two clinical isolates with distinct neurovirulence-...