The guanosine nucleotide analog bemnifosbuvir inhibits hepatitis E virus infection in cell and organoid models [0.03%]
鸟苷类似物贝尼福布韦在细胞和类器官模型中抑制戊型肝炎病毒感染
Kuan Liu,Yang Wang,Xincheng Li et al.
Kuan Liu et al.
The epidemiology and disease burden of enterovirus infections among hospitalized children in China: An 8-year national cross-sectional study [0.03%]
中国住院儿童肠道病毒感染流行病学与疾病负担的8年全国性横断面研究
Yi Wang,Fei Li,Hui Xu et al.
Yi Wang et al.
Enterovirus (EV) infections represent a significant global and national health concern in children, leading to various complications. Although most children with EV infections generally have a favorable prognosis, a small proportion may sti...
A comprehensive RNA virome from molluscan transcriptomes reveals extensive diversity and modular genome evolution [0.03%]
来自软体动物转录组的全面RNA病毒组揭示了广泛的多样性和模块化基因组演化
Jiaxiang Li,Kewei Chen,Xin Chen et al.
Jiaxiang Li et al.
Mollusca, the second-largest animal phylum, includes many aquaculture species used as important food resources for humans. While DNA viruses that threaten molluscan aquaculture have received much attention, molluscan RNA viromes are still u...
Metagenomic and serological evidence of emerging tick-borne viruses in livestock, humans, and rats in Pakistan [0.03%]
巴基斯坦家畜、人类和鼠类中传播的新型蜱传病毒的元基因组学及血清学证据
Muhammad Ammar,Yaohui Fang,Muhammad Saqib et al.
Muhammad Ammar et al.
Tick-borne viruses (TBVs) pose significant emerging threats to public and veterinary health worldwide. In Pakistan, the potential threats posed by TBVs extend far beyond Crimean-Congo hemorrhagic fever virus (CCHFV), which causes outbreaks ...
Antiviral activity of Saponin C from Liriope muscari against influenza A virus and SARS-CoV-2 [0.03%]
抗流感病毒和新冠病毒的石蒜皂苷C体外活性研究
Yuhan Gong,Junwen Liu,Wenxuan Ding et al.
Yuhan Gong et al.
Saponin C (also known as DT-13) is the dominant ingredient extracted from the tuber of Liriope muscari (Decne.) L. H. Bailey, which exhibits multiple pharmacological activities, including anti-tumor, anti-thrombotic, cardioprotective and an...
ASFV pA137R protein triggers inflammatory response by inducing NF-κB signaling pathway and facilitating NLRP3 inflammasome assembly [0.03%]
pA137R蛋白通过诱导NF-κB信号通路并促进NLRP3炎性小体的组装来触发炎症反应
Yi Zeng,Xiaohong Liu,Siqi Dong et al.
Yi Zeng et al.
African swine fever (ASF), caused by the African swine fever virus (ASFV), is characterized by high mortality in infected pigs. ASFV infection triggers severe inflammatory response in the host, which is a crucial contributor to the high let...
EV-A71 induces GSDME-dependent T-cell pyroptosis: A novel mechanism and MeCbl therapeutic potential [0.03%]
肠道病毒A71诱导的GSDME依赖性T细胞焦亡：一种新的机制及MeCbl治疗潜力
Chong Wang,Bingyu Guo,Yilin Li et al.
Chong Wang et al.
Enterovirus A71 (EV-A71) is the primary pathogen causing severe hand-foot-and-mouth disease (HFMD) in young children, with T-cell immune dysfunction closely linked to severe clinical outcomes. However, the molecular mechanisms underlying EV...
A C-type single-domain antibody with protective efficacy against H1N1 via respiratory administration [0.03%]
一种具有雾化吸入保护效果的抗H1N1人源C型单域抗体
Bihao Wu,Haiwei Zhang,Xiangxing He et al.
Bihao Wu et al.
Influenza A viruses, particularly H1N1, pose a significant public health threat, highlighting the continued need for novel prophylactics and therapeutics. Monoclonal antibodies are promising, but conventional IgGs face challenges in respira...
Identification and geographic evolutionary analysis of human pegivirus infection based on metatranscriptomic sequencing [0.03%]
基于宏转录组测序的HPgV感染的鉴定及地理进化分析
Shan Lu,Pei-Yu Zhen,Cai Bian et al.
Shan Lu et al.
Induction of mitochondrial fission and mtDNA leakage via the Smad3/Drp1 axis by PEDV infection activates the TLR9/NF-κB/IL-1β inflammatory pathway [0.03%]
猪流行性腹泻病毒感染通过Smad3/Drp1轴诱导线粒体分裂和mtDNA泄露，激活TLR9/NF-κB/IL-1β炎症通路
Hangao Xie,Jinlian Guan,Fengjie Tian et al.
Hangao Xie et al.
Mitochondrial homeostasis is intricately linked to the pathogenesis of many viral infections. The maintenance of mitochondrial homeostasis and normal cellular functions relies heavily on the delicate balance of mitochondrial dynamics. Howev...