Predicting mortality risk of severe fever with thrombocytopenia syndrome: a multi-center retrospective cohort study [0.03%]
严重发热伴血小板减少综合征死亡风险预测：多中心回顾性队列研究
Xue-Geng Hong,Hong-Han Ge,Ning Cui et al.
Xue-Geng Hong et al.
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease with high mortality, and clinical practice lacks dynamic tools to assess its rapidly evolving course. This study aims to develop stage-specific machine lea...
An adenovirus-vectored recombinant vaccine confers passive immunity protection from swine acute diarrhea syndrome coronavirus challenge in neonatal mice [0.03%]
一种腺病毒载体重组疫苗通过被动免疫保护仔鼠免受猪急性腹泻综合征冠状病毒的攻击
Yu Zhang,Yueyue Duan,Xueliang Zhu et al.
Yu Zhang et al.
Swine Acute Diarrhea Syndrome Coronavirus (SADS-CoV), an emerging bat-origin Alphacoronavirus with demonstrated zoonotic potential, poses a significant threat to swine health and has considerable economic implications. Currently, no license...
Meta-transcriptomic analysis of tick virome diversity and ecological characteristics in Yunnan Province, southwestern China [0.03%]
云南省 ticks病毒组的多样性及生态特征的元转录组分析
Rong Xiang,Fengjuan Tian,Jing Li et al.
Rong Xiang et al.
Emerging tick-borne viruses are posing an increasing health concern. However, there is limited knowledge about the distribution characteristics of tick virome in Yunnan Province, southwestern China, where it is distinguished by its diverse ...
Deep Data-independent Acquisition-based Plasma Proteomic Profiling Unveils Distinct Molecular Features in Dengue Fever with Neutropenia [0.03%]
基于深度数据无关采集的血浆蛋白质组谱分析揭示登革热伴中性粒细胞减少症的独特分子特征
Guanyong Ou,Jun Wang,Rongrong Zou et al.
Guanyong Ou et al.
Dengue virus (DENV) remains a pervasive global health threat, further complicated by the occurrence of neutropenia-a distinct clinical feature indicative of an altered host immune response, closely correlated with progressive disease deteri...
A decreased proportion of naïve MAIT cells is associated with the incomplete immune reconstitution in antiretroviral therapy-treated HIV-1 patients [0.03%]
与接受抗逆转录病毒治疗的人类免疫缺陷病毒(HIV-1)患者不完全免疫重建相关的新鲜多毛样天然杀伤T细胞比例降低
Jie Jia,Hong-Yi Zheng,Yu Zhao et al.
Jie Jia et al.
Incomplete immune reconstitution occurs in 10%-40% of antiretroviral therapy (ART)-treated human immunodeficiency virus 1 (HIV-1) patients. This subset of immunological non-responders (INRs) has yet to undergo a comprehensive analysis of im...
Ubiquitin-specific protease 5 promotes EV-A71 replication by de-ubiquitinating MAVS and IRF3 [0.03%]
泛素特异性蛋白酶5通过去泛素化MAVS和IRF3促进EV-A71复制
Shumin Zhang,Yuan Fang,Shuai Ren et al.
Shumin Zhang et al.
Human enterovirus A71 (EV-A71) is a major causative agent of hand, foot and mouth disease (HFMD), which poses a significant public health threat, particularly among young children. Mitochondrial antiviral signaling protein (MAVS) and interf...
RNA and ChIP-sequencing analysis reveals SOX3 suppresses antiviral innate immunity through the AKT1-PTEN signaling axis [0.03%]
RNA和ChIP测序分析揭示SOX3通过AKT1-PTEN信号轴抑制抗病毒先天免疫反应
Tanzeel Yousaf,Jianwen Chen,Wajeeha Naz et al.
Tanzeel Yousaf et al.
The transcription factor Sex-determining region Y-box protein 3 (SOX3) is well known for its critical roles in sex determination and cell differentiation; however, its function in antiviral innate immunity remains unexplored. This study unc...
Neutralization of Crimean-Congo hemorrhagic fever pseudotyped virions with heavy chain antibodies [0.03%]
重型链抗体对伪嗜峰热病毒的中和作用
Kewen Qian,Yu Zhang,Zhihao Li et al.
Kewen Qian et al.
Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic tick-borne virus that causes severe hemorrhagic fever with high mortality rates in humans. No licensed vaccines or efficacious antiviral therapies are currently available....
Genomic assembly, rescue, and characterization of a functional pseudorabies virus [0.03%]
伪狂犬病病毒的基因组序列测定、修复及功能表征
Hengrui Hu,Xiquan Ke,Han Xiao et al.
Hengrui Hu et al.
With recent advances in synthetic biology methods, the genomes of several large DNA viruses have been de novo synthesized and assembled, leading to the functional rescue of the respective viruses. Pseudorabies virus (PRV), a large DNA virus...
Specific and visual detection of EBOV based on a one-pot RT-RAA-CRISPR/Cas12a assay [0.03%]
基于一锅法RT-RAA-CRISPR / Cas12a试检埃博拉病毒的可视化检测方法
Zanheng Huang,Pei Huang,Zengguo Cao et al.
Zanheng Huang et al.