Proteolysis and Deficiency of α1-Proteinase Inhibitor in SARS-CoV-2 Infection [0.03%]
SARS-CoV-2感染中的α1-蛋白酶抑制剂的水解和缺乏现象
O E Akbasheva,L V Spirina,D A Dyakov et al.
O E Akbasheva et al.
The SARS-CoV-2 pandemic had stimulated the emergence of numerous publications on the α1-proteinase inhibitor (α1-PI, α1-antitrypsin), especially when it was found that the regions of high mortality corresponded to the regions with defici...
Clinical and Diagnostic Significance of Sialic Acids Determination in Biological Material [0.03%]
生物样品中唾液酸测定的临床及诊断意义
I V Volkhina,E G Butolin
I V Volkhina
Sialic acids (SA) are neuraminic acid derivatives, located at the terminal position in the chains of monosaccharide residues of various glycoconjugates. SA play a dual role: they either mask recognition sites, or, on the contrary, represent...
Atmospheric Reactive Oxygen Species and Some Aspects of the Antiviral Protection at the Respiratory Epithelium [0.03%]
大气活性氧和呼吸道上皮抗病毒保护的某些方面
V V Salmin,A V Morgun,R Ya Olovyannikova et al.
V V Salmin et al.
The review summarizes literature data on molecular and biochemical mechanisms of nonspecific protection of respiratory epithelium. The special attention is paid to comprehensive analysis of up-to-date data on the activity of the lactoperoxi...
The Effect of Methylene Blue and Its Metabolite-Azure I-on Bioenergetic Parameters of Intact Mouse Brain Mitochondria [0.03%]
亚甲蓝及其代谢产物azure I对完整小鼠脑线粒体生物能量参数的影响
A P Gureev,N A Samoylova,D V Potanina et al.
A P Gureev et al.
Methylene blue, a phenothiazine dye, that is widely used in medicine and is under clinical trials as an agent for treatment of Alzheimer's disease. One of the factors of the unique therapeutic effect of methylene blue is its redox propertie...
Antifungal Macrocycle Antibiotic Amphotericin B-Its Present and Future. Multidisciplinary Perspective for the Use in the Medical Practice [0.03%]
抗真菌大环抗生素两性霉素B——现状与未来。医学实践应用的多学科视角
A A Baghirova,Kh M Kasumov
A A Baghirova
This review is devoted to a broad analysis of the results of studies of the effect of macrocyclic antifungal polyene antibiotic amphotericin B on cell membranes. A detailed study of polyenes has shown that some of them can have not only ant...
Peptide Inhibitors of the Interaction of the SARS-CoV-2 Receptor-Binding Domain with the ACE2 Cell Receptor [0.03%]
肽抑制剂对新冠病毒受体结合域与ACE2细胞受体相互作用的抑制作用
R Sh Bibilashvili,M V Sidorova,U S Dudkina et al.
R Sh Bibilashvili et al.
Computer simulation has been used to identify peptides that mimic the natural target of the SARS-CoV-2 coronavirus spike (S) protein, the angiotensin-converting enzyme type 2 (ACE2) cell receptor. Based on the structure of the complex of th...
S N Naryzny,O K Legina
S N Naryzny
Haptoglobin (Hp) is a glycoprotein that binds free hemoglobin (Hb) in plasma and plays a critical role in tissue protection and prevention of oxidative damage. Besides, it has some regulatory functions. Haptoglobin is an acute-phase protein...
Prediction of the Inhibition of Influenza Virus Neuraminidase Various Strains by Means of a Generalized Model Constructed Using the Data on the Position of Known Ligands [0.03%]
基于已知配体位置数据构建通用模型预测各种流感病毒神经氨酸酶的抑制作用
A V Mikurova,A V Rybina,V S Skvortsov
A V Mikurova
Several variants of models for predicting the IC50 values of inhibitors of influenza virus neuraminidase are presented for both individual strains and also for combinations of data for neuraminidases of several strains. They are based on th...
Osteogenic and Angiogenic Properties of Heparin as a System for Delivery of Biomolecules for Bone Bioengineering: a Brief Critical Review [0.03%]
作为骨组织工程生物分子递送系统的肝素的促血管生成和成骨性能的简要综述
L S Litvinova,K A Yurova,O G Khaziakhmatova et al.
L S Litvinova et al.
The review considers complex, controversial, and individual effects of heparin and its derivatives on the bone and circulatory systems in dependence of the dose, the state of the cells and tissues of the recipient. General data on the antic...
V A Spiridonova
V A Spiridonova
The review summarizes data on DNA/RNA aptamers, a novel class of molecular recognition elements. Special attention is paid to the aptamers to proteins involved into pathogenesis of wide spread human diseases. These include aptamers to serin...