P P Avdonin,E Yu Rybakova,S K Trufanov et al.
P P Avdonin et al.
The new coronavirus infection (COVID-19) pandemic caused by SARS-CoV-2 has many times surpassed the epidemics caused by SARS-CoV and MERS-CoV. The reason for this was the presence of sites in the protein sequence of SARS-CoV-2 that provide ...
Physico-Chemical Mechanisms of the Functioning of Membrane-Active Proteins of Enveloped Viruses [0.03%]
有包膜病毒的膜活性蛋白的功能物理化学机制
O V Batishchev
O V Batishchev
Over the past few years, the attention of the whole world has been riveted to the emergence of new dangerous strains of viruses, among which a special place is occupied by coronaviruses that have overcome the interspecies barrier in the pas...
The Mechanisms of Lipid Vesicle Fusion Inhibition by Extracts of Chaga and Buckthorn Leaves [0.03%]
牛樟子和醋栗叶提取物抑制脂质小泡融合的机制
S S Efimova,P D Zlodeeva,E V Shekunov et al.
S S Efimova et al.
The ability of extracts of grapefruit seeds (ESG), sea buckthorn leaves (ESBL), and chaga (EC) to inhibit membrane fusion was evaluated. It was found that ESBL and EC inhibited Ca2+-mediated fusion of phosphatidylglycerol-enriched lipid ves...
E I Yakubovich,A G Polischouk,V I Evtushenko
E I Yakubovich
Exosomes, the subclass of small membrane extracellular vesicles, have great diagnostic and therapeutic potential, but the lack of standardized methods for their efficient isolation and analysis limits the introduction of exosomal technologi...
D S Tretiakova,E L Vodovozova
D S Tretiakova
The review considers liposomes as systems of substantial interest as adjuvant carriers in vaccinology due to their versatility and maximal biocompatibility. Research and development on the use of liposomes and lipid nanoparticles to create ...
Structure and Functions of Gap Junctions and Their Constituent Connexins in the Mammalian CNS [0.03%]
哺乳动物中枢神经系统中缝隙连接及其组成蛋白连接蛋白的结构与功能
E Yu Kirichenko,S N Skatchkov,A M Ermakov
E Yu Kirichenko
Numerous data obtained in the last 20 years indicate that all parts of the mature central nervous system, from the retina and olfactory bulb to the spinal cord and brain, contain cells connected by gap junctions (GJs). The morphological bas...
The Balance between Two Branches of RAS Can Protect from Severe COVID-19 Course [0.03%]
RAS两条通路的平衡可以预防严重新冠肺炎病情
N V Bobkova
N V Bobkova
The COVID-19 pandemic has swept the world and required the mobilization of scientists and clinicians around the world to combat this serious disease. Along with SARS-CoV-2 virology research, understanding of the fundamental physiological pr...
Modulation of the Cholesterol-Dependent Activity of Macrophages IC-21 by CRAC Peptides with Substituted Motif-Forming Amino Acids [0.03%]
胆固醇依赖的巨噬细胞IC-21活性调控肽CRAC及其构象形成氨基酸替换变异体的研究
A Ya Dunina-Barkovskaya,Kh S Vishnyakova
A Ya Dunina-Barkovskaya
The activity of many membrane proteins, such as receptors, ionic channels, transporters, and enzymes, is cholesterol dependent; however, mechanisms of the cholesterol-dependent regulation of protein functions remain obscure. Recent studies ...
N V Goncharov,P I Popova,P P Avdonin et al.
N V Goncharov et al.
Endothelial cells (ECs) line the blood vessels and lymphatic vessels, as well as heart chambers, forming the border between the tissues, on the one hand, and blood or lymph, on the other. Such a strategic position of the endothelium determi...
D V Ilatovskaya,T S Pavlov,Y A Negulyaev et al.
D V Ilatovskaya et al.
Family focal segmental glomerulosclerosis (FSGS) is characterized by sclerosis and hyalinosis of particular loops of glomeruli and is one of the causes of the nephrotic syndrome. Certain mutations in the structure of TRPC6 channels are the ...