Britanin Suppresses IgE/Ag-Induced Mast Cell Activation by Inhibiting the Syk Pathway [0.03%]
溴化丁基苯抑制IgE/Ag诱导的肥大细胞活化及其机制研究——MAP激酶和Syk信号途径角度
Yue Lu,Xian Li,Young Na Park et al.
Yue Lu et al.
The aim of this study was to determine whether britanin, isolated from the flowers of Inula japonica (Inulae Flos), modulates the generation of allergic inflammatory mediators in activated mast cells. To understand the biological activity o...
β-lapachone-Induced Apoptosis of Human Gastric Carcinoma AGS Cells Is Caspase-Dependent and Regulated by the PI3K/Akt Pathway [0.03%]
β-lapachone诱导的人胃癌AGS细胞凋亡是由caspase介导并由PI3K/Akt途径调节的
Hai Yang Yu,Sung Ok Kim,Cheng-Yun Jin et al.
Hai Yang Yu et al.
β-lapachone is a naturally occurring quinone that selectively induces apoptotic cell death in a variety of human cancer cells in vitro and in vivo; however, its mechanism of action needs to be further elaborated. In this study, we investig...
Houttuynia cordata Improves Cognitive Deficits in Cholinergic Dysfunction Alzheimer's Disease-Like Models [0.03%]
蕺菜改善胆碱能功能损伤的阿尔茨海默病样模型小鼠的认知缺陷作用研究
Eugene Huh,Hyo Geun Kim,Hanbyeol Park et al.
Eugene Huh et al.
Cognitive impairment is a result of dementia of diverse causes, such as cholinergic dysfunction and Alzheimer's disease (AD). Houttuynia cordata Thunb. (Saururaceae) has long been used as a traditional herbal medicine. It has biological act...
Young Sik Cho,Seung Yeon Park
Young Sik Cho
Chemotherapy has long been considered as one of useful strategies for cancer treatment. It is primarily based on the apoptosis that can selectively kill cancer cells. However, cancer cells can progressively develop an acquired resistance to...
A novel in situ gel formulation of ranitidine for oral sustained delivery [0.03%]
一种用于口服缓释的雷尼替丁原位凝胶新型制剂
Haoping Xu,Min Shi,Ying Liu et al.
Haoping Xu et al.
The main purpose of this study was to develop a novel, in situ gel system for sustained delivery of ranitidine hydrochloride. Ranitidine in situ gels at 0.2%, 0.5%, and 1.0% gellan gum concentration (w/v) were prepared, respectively, and ch...
A Comparison of the In Vitro Inhibitory Effects of Thelephoric Acid and SKF-525A on Human Cytochrome P450 Activity [0.03%]
石耳酸对人细胞色素P450酶的体外抑制作用及其与SKF-525A的比较研究
Min Song,Hyunhee Do,Oh Kwang Kwon et al.
Min Song et al.
Thelephoric acid is an antioxidant produced by the hydrolysis of polyozellin, which is isolated from Polyozellus multiplex. In the present study, the inhibitory effects of polyozellin and thelephoric acid on 9 cytochrome P450 (CYP) family m...
Protective Effects of Diallyl Sulfide against Thioacetamide-Induced Toxicity: A Possible Role of Cytochrome P450 2E1 [0.03%]
大蒜素对硫代乙酰胺致肝损伤的保护作用及对CYP2E1的影响
Nam Hee Kim,Sangkyu Lee,Mi Jeong Kang et al.
Nam Hee Kim et al.
Effects of diallyl sulfide (DAS) on thioacetamide-induced hepatotoxicity and immunotoxicity were investigated. When male Sprague-Dawley rats were treated orally with 100, 200 and 400 mg/kg of DAS in corn oil for three consecutive days, the ...
Analysis of disease progression-associated gene expression profile in fibrillin-1 mutant mice: new insight into molecular pathogenesis of marfan syndrome [0.03%]
基于FBN1突变小鼠的疾病进展相关基因表达谱分析：Marfan综合征分子病理的新视角
Koung Li Kim,Chanmi Choi,Wonhee Suh
Koung Li Kim
Marfan syndrome (MFS) is a dominantly inherited connective tissue disorder caused by mutations in the gene encoding fibrillin-1 (FBN1) and is characterized by aortic dilatation and dissection, which is the primary cause of death in untreate...
The Polyphenol Chlorogenic Acid Attenuates UVB-mediated Oxidative Stress in Human HaCaT Keratinocytes [0.03%]
没食子酰基奎宁酸氯原酸对紫外线诱导的人表皮角质细胞氧化损伤的保护作用
Ji Won Cha,Mei Jing Piao,Ki Cheon Kim et al.
Ji Won Cha et al.
We investigated the protective effects of chlorogenic acid (CGA), a polyphenol compound, on oxidative damage induced by UVB exposure on human HaCaT cells. In a cell-free system, CGA scavenged 1,1-diphenyl-2-picrylhydrazyl radicals, superoxi...
Action and Signaling of Lysophosphatidylethanolamine in MDA-MB-231 Breast Cancer Cells [0.03%]
溶血磷脂乙醇胺在MDA-MB-231乳腺癌细胞中的作用和信号转导
Soo-Jin Park,Kyoung-Pil Lee,Dong-Soon Im
Soo-Jin Park
Previously, we reported that lysophosphatidylethanolamine (LPE), a lyso-type metabolite of phosphatidylethanolamine, can increase intracellular Ca(2+) ([Ca(2+)]i) via type 1 lysophosphatidic acid (LPA) receptor (LPA1) and CD97, an adhesion ...