Genetically engineered mouse models for drug development and preclinical trials [0.03%]
药物研发和临床前试验的基因工程小鼠模型
Ho Lee
Ho Lee
Drug development and preclinical trials are challenging processes and more than 80% to 90% of drug candidates fail to gain approval from the United States Food and Drug Administration. Predictive and efficient tools are required to discover...
Comparison of piroxicam pharmacokinetics and anti-inflammatory effect in rats after intra-articular and intramuscular administration [0.03%]
不同给药途径注射吡罗昔康的药动学及抗炎效应比较研究
Chan Woong Park,Kyung Wan Ma,Sun Woo Jang et al.
Chan Woong Park et al.
This study evaluated the pharmacokinetic profile and therapeutic efficacy of piroxicam (PX), a long acting non-steroidal anti-inflammatory drug for the treatment of arthritis, following intra-articular (IA) injection in comparison to the ph...
Enhancement of platelet aggregation by ursolic Acid and oleanolic Acid [0.03%]
乌索酸和齐墩果酸对血小板聚集的影响增强作用
Mikyung Kim,Chang-Ho Han,Moo-Yeol Lee
Mikyung Kim
The pentacyclic triterpenoid ursolic acid (UA) and its isomer oleanolic acid (OA) are ubiquitous in food and plant medicine, and thus are easily exposed to the population through natural contact or intentional use. Although they have divers...
Jin Bae Weon,Bo-Ra Yun,Jiwoo Lee et al.
Jin Bae Weon et al.
Codonopsis lanceolata has been used as an herbal medicine for several lung inflammatory diseases, such as asthma, tonsillitis, and pharyngitis. Previously, we showed the neuroprotective effect of steamed and fermented C. lanceolata (SFC) in...
Luteolin Inhibits the Activity, Secretion and Gene Expression of MMP-3 in Cultured Articular Chondrocytes and Production of MMP-3 in the Rat Knee [0.03%]
黄芩素抑制培养的关节软骨细胞中MMP-3的活性、分泌及基因表达和大鼠膝关节中MMP-3的产生
Bun-Jung Kang,Jiho Ryu,Choong Jae Lee et al.
Bun-Jung Kang et al.
We investigated whether luteolin affects the gene expression, secretion and activity of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as production of MMP-3 in the rat knee to evaluate the pot...
Amelioration of Cognitive Dysfunction in APP/PS1 Double Transgenic Mice by Long-Term Treatment of 4-O-Methylhonokiol [0.03%]
4-氧甲基Honokiol长期改善APP / PS1双转基因小鼠认知障碍的作用及机制研究
Yu-Yeon Jung,Young-Jung Lee,Dong-Young Choi et al.
Yu-Yeon Jung et al.
Alzheimer's disease (AD) is the most common neurodegenerative disease without known ways to cure. A key neuropathologic manifestation of the disease is extracellular deposition of beta-amyloid peptide (Aβ). Specific mechanisms underlying t...
Cordycepin-Enriched WIB801C from Cordyceps militaris Inhibits Collagen-Induced [Ca(2+)]i Mobilization via cAMP-Dependent Phosphorylation of Inositol 1, 4, 5-Trisphosphate Receptor in Human Platelets [0.03%]
虫草素富集的WIB801C通过cAMP依赖性肌醇1,4,5-三磷酸受体磷酸化抑制 collagen诱导的人血小板[Ca(2+)]i动员作用研究
Dong-Ha Lee,Hyun-Hong Kim,Hyun-Jeong Cho et al.
Dong-Ha Lee et al.
In this study, we prepared cordycepin-enriched (CE)-WIB801C, a n-butanol extract of Cordyceps militaris-hypha, and investigated the effect of CE-WIB801C on collagen-induced human platelet aggregation. CE-WIB801C dose-dependently inhibited c...
L-tetrahydropalmatine ameliorates development of anxiety and depression-related symptoms induced by single prolonged stress in rats [0.03%]
L-四氢 palmatine改善单次长时间应激大鼠诱发的焦虑和抑郁相关症状
Bombi Lee,Bongjun Sur,Mijung Yeom et al.
Bombi Lee et al.
Abnormal adaptation of the stress-response system following traumatic stress can lead to alterations in the hypothalamic-pituitary-adrenal (HPA) axis that may contribute to the development of post-traumatic stress disorder (PTSD). The prese...
Involvement of Transglutaminase-2 in α-MSH-Induced Melanogenesis in SK-MEL-2 Human Melanoma Cells [0.03%]
α-MSH诱导的SK-MEL-2人黑色素瘤细胞黑素生成与转谷氨酰胺酶-2的关系研究
Hyun Ji Kim,Hye Ja Lee,Mi Kyung Park et al.
Hyun Ji Kim et al.
Skin hyperpigmentation is one of the most common skin disorders caused by abnormal melanogenesis. The mechanism and key factors at play are not fully understood. Previous reports have indicated that cystamine (CTM) inhibits melanin synthesi...
N-(p-Coumaryol)-Tryptamine Suppresses the Activation of JNK/c-Jun Signaling Pathway in LPS-Challenged RAW264.7 Cells [0.03%]
N-(对芸香豆芽碱基葡萄糖醛酸苷)-色氨酸类似胺通过抑制JNK/c-Jun信号途径发挥抗炎活性
Van Anh Vo,Jae-Won Lee,Jun-Ho Park et al.
Van Anh Vo et al.
N-(p-Coumaryol) tryptamine (CT), a phenolic amide, has been reported to exhibit anti-oxidant and anti-inflammatory activities. However, the underlying mechanism by which CT exerts its pharmacological properties has not been clearly demonstr...