Anti-Inflammatory and PPAR Transactivational Effects of Oleanane-Type Triterpenoid Saponins from the Roots of Pulsatilla koreana [0.03%]
朝鲜延胡索根中齐墩果烷型三萜皂苷的抗炎和PPAR激动活性研究
Wei Li,Xi Tao Yan,Ya Nan Sun et al.
Wei Li et al.
In this study, 23 oleanane-type triterpenoid saponins were isolated from a methanol extract of the roots of Pulsatilla koreana. The NF-κB inhibitory activity of the isolated compounds was measured in TNFα-treated HepG2 cells using a lucif...
Adipose-derived stem cells improve efficacy of melanocyte transplantation in animal skin [0.03%]
脂肪来源干细胞提高黑色素细胞移植效果研究
Won-Suk Lim,Chang-Hyun Kim,Ji-Young Kim et al.
Won-Suk Lim et al.
Vitiligo is a pigmentary disorder induced by a loss of melanocytes. In addition to replacement of pure melanocytes, cocultures of melanocytes with keratinocytes have been used to improve the repigmentation outcome in vitiligo treatment. We ...
Dermal Stability and In Vitro Skin Permeation of Collagen Pentapeptides (KTTKS and palmitoyl-KTTKS) [0.03%]
胶原五肽(KTTKS和棕榈酸-KTTKS)的皮肤稳定性及体外经皮渗透性研究
Yun Lim Choi,Eun Ji Park,Eunje Kim et al.
Yun Lim Choi et al.
Collagen pentapeptide (Lys-Thr-Thr-Lys-Ser, KTTKS) and its palmitoylated derivative (pal-KTTKS) have received a great deal of attention as cosmeceutical ingredients for their anti-wrinkle effects. The objective of this study was to evaluate...
Pachymic Acid Enhances Pentobarbital-Induced Sleeping Behaviors via GABAA-ergic Systems in Mice [0.03%]
厚朴酚通过GABAA能系统增强戊巴比妥诱导的小鼠睡眠行为
Vikash Kumar Shah,Jae Joon Choi,Jin-Yi Han et al.
Vikash Kumar Shah et al.
This study was investigated to know whether pachymic acid (PA), one of the predominant triterpenoids in Poria cocos (Hoelen) has the sedative-hypnotic effects, and underlying mechanisms are mediated via γ-aminobutyric acid (GABA)-ergic sys...
The Heterochromatin-1 Phosphorylation Contributes to TPA-Induced AP-1 Expression [0.03%]
TPA诱导的AP-1表达与异染色质蛋白1磷酸化有关
Won Jun Choi
Won Jun Choi
Activator protein-1 (AP-1) is an inducible transcription factor that contributes to the generation of chronic inflammation in response to oxidative and electrophilic stress. Previous studies have demonstrated that the PI3K/Akt1 pathway play...
Fucodiphlorethol G Purified from Ecklonia cava Suppresses Ultraviolet B Radiation-Induced Oxidative Stress and Cellular Damage [0.03%]
岩茵陈(Ecklonia cava)中分离得到的Fucodiphlorethol G可抑制紫外线B引起的氧化应激及细胞损伤作用
Ki Cheon Kim,Mei Jing Piao,Jian Zheng et al.
Ki Cheon Kim et al.
Fucodiphlorethol G (6'-[2,4-dihydroxy-6-(2,4,6-trihydroxyphenoxy)phenoxy]biphenyl-2,2',4,4',6-pentol) is a compound purified from Ecklonia cava, a brown alga that is widely distributed offshore of Jeju Island. This study investigated the pr...
Mi-Yeon Kim,Jong-Hoon Kim,Jae Youl Cho
Mi-Yeon Kim
The actin cytoskeleton plays an important role in macrophage-mediated inflammatory responses by modulating the activation of Src and subsequently inducing nuclear factor (NF)-κB translocation. In spite of its critical functions, few papers...
Anti-Inflammatory Effect of Mangostenone F in Lipopolysaccharide-Stimulated RAW264.7 Macrophages by Suppressing NF-κB and MAPK Activation [0.03%]
通过抑制NF-κB和MAPK活化 槟榔西酮F对脂多糖刺激的RAW264.7巨噬细胞的抗炎作用
Byoung Ok Cho,Hyung Won Ryu,Yangkang So et al.
Byoung Ok Cho et al.
Mangostenone F (MF) is a natural xanthone isolated from Garcinia mangostana. However, little is known about the biological activities of MF. This study was designed to investigate the anti-inflammatory effect and underlying molecular mechan...
Silymarin Inhibits Cytokine-Stimulated Pancreatic Beta Cells by Blocking the ERK1/2 Pathway [0.03%]
丝利马林通过阻断ERK1 / 2通路抑制细胞因子刺激的胰岛β细胞
Eun Jeong Kim,Jeeho Kim,Min Young Lee et al.
Eun Jeong Kim et al.
We show that silymarin, a polyphenolic flavonoid isolated from milk thistle (Silybum marianum), inhibits cytokine mixture (CM: TNF-α, IFN-γ, and IL-1β)-induced production of nitric oxide (NO) in the pancreatic beta cell line MIN6N8a. Imm...
Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells [0.03%]
没食子酸通过自噬诱导在SH-SY5Y细胞中发挥神经保护作用
Hee Ju Kim,Joonki Kim,Ki Sung Kang et al.
Hee Ju Kim et al.
Autophagy is a series of catabolic process mediating the bulk degradation of intracellular proteins and organelles through formation of a double-membrane vesicle, known as an autophagosome, and fusing with lysosome. Autophagy plays an impor...