HD047703, a New Promising Anti-Diabetic Drug Candidate: In Vivo Preclinical Studies [0.03%]
新型降糖药物先导化合物HD047703的体内药效学研究
SoRa Kim,Dae Hoon Kim,Young-Seok Kim et al.
SoRa Kim et al.
G-protein coupled receptor 119 (GPR119) has emerged as a novel target for the treatment of type 2 diabetes mellitus. GPR119 is involved in glucose-stimulated insulin secretion (GSIS) from the pancreatic β-cells and intestinal cells. In thi...
TI-I-174, a Synthetic Chalcone Derivative, Suppresses Nitric Oxide Production in Murine Macrophages via Heme Oxygenase-1 Induction and Inhibition of AP-1 [0.03%]
合成查耳酮衍生物TI-I-174通过诱导血红素氧合酶-1和抑制活化蛋白-1的活性抑制小鼠巨噬细胞中的一氧化氮生成作用
Mi Jin Kim,Taraman Kadayat,Da Eun Kim et al.
Mi Jin Kim et al.
Chalcones (1,3-diaryl-2-propen-1-ones), a flavonoid subfamily, are widely known for their anti-inflammatory properties. Propenone moiety in chalcones is known to play an important role in generating biological responses by chalcones. In the...
Regulatory role of autophagy in globular adiponectin-induced apoptosis in cancer cells [0.03%]
自噬在球状脂联素诱导的癌细胞凋亡中的调控作用
Saroj Nepal,Pil-Hoon Park
Saroj Nepal
Adiponectin, an adipokine predominantly secreted from adipose tissue, exhibits diverse biological responses, including metabolism of glucose and lipid, and apoptosis in cancer cells. Recently, adiponectin has been shown to modulate autophag...
Caenorhabditis elegans: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification [0.03%]
秀丽隐杆线虫：一类抗癌药物发现和治疗靶点识别的模型系统
Robert A Kobet,Xiaoping Pan,Baohong Zhang et al.
Robert A Kobet et al.
The nematode Caenorhabditis elegans (C. elegans) offers a unique opportunity for biological and basic medical researches due to its genetic tractability and well-defined developmental lineage. It also provides an exceptional model for genet...
Erratum to "Microfluidic System Based High Throughput Drug Screening System for Curcumin/TRAIL Combinational Chemotherapy in Human Prostate Cancer PC3 Cells" [Biomol. Ther. 22 (2014) 355-362] [0.03%]
“姜黄素/TRAIL联合化疗的高通量药物筛选系统的微流控芯片研究（ Biomol. Ther. 22 (2014) 355-362）”一文勘误通知
Dami An,Kwangmi Kim,Jeongyun Kim
Dami An
[This corrects the article on p. 355 in vol. 22, PMID: 25143816.].
Published Erratum
Biomolecules & therapeutics. 2014 Sep;22(5):475. DOI:10.4062/biomolther.2014.475 2014
Erratum to "l-tetrahydropalmatine ameliorates development of anxiety and depression-related symptoms induced by single prolonged stress in rats" [biomol. Ther. 22 (2014) 213-222] [0.03%]
关于"L-四氢帕马汀改善单次长时间应激大鼠诱导的焦虑和抑郁样症状"[Biomol. Ther. 22 (2014) 213-222]的勘误修正通知
Bombi Lee,Bongjun Sur,Mijung Yeom et al.
Bombi Lee et al.
[This corrects the article on p. 213 in vol. 22, PMID: 25009702.].
Published Erratum
Biomolecules & therapeutics. 2014 Sep;22(5):474. DOI:10.4062/biomolther.2014.474 2014
Dependence Potential of the Synthetic Cannabinoids JWH-073, JWH-081, and JWH-210: In Vivo and In Vitro Approaches [0.03%]
合成大麻素JWH-073、JWH-081和JWH-210的成瘾潜力：体内与体外方法
Hye Jin Cha,Kwang-Wook Lee,Min-Ji Song et al.
Hye Jin Cha et al.
Synthetic cannabinoids (CBs) such as the JWH series have caused social problems concerning their abuse liability. Because the JWH series produces euphoric and hallucinogenic effects, they have been distributed illegally under street names s...
Microfluidic System Based High Throughput Drug Screening System for Curcumin/TRAIL Combinational Chemotherapy in Human Prostate Cancer PC3 Cells [0.03%]
基于微流控系统的姜黄素/TRAIL联合化疗高通量药物筛选系统用于人前列腺癌PC3细胞研究
Dami An,Kwangmi Kim,Jeongyun Kim
Dami An
We have developed a fully automated high throughput drug screening (HTDS) system based on the microfluidic cell culture array to perform combinational chemotherapy. This system has 64 individually addressable cell culture chambers where the...
Selective Estrogen Receptor Modulation by Larrea nitida on MCF-7 Cell Proliferation and Immature Rat Uterus [0.03%]
拉莱亚树脂《拉莱亚 nitida》对MCF-7细胞增殖和幼年大鼠子宫的雌激素受体选择性调节作用
Hye-Na Ahn,Si-Yeon Jeong,Gyu-Un Bae et al.
Hye-Na Ahn et al.
Larrea nitida is a plant that belongs to the Zygophyllaceae family and is widely used in South America to treat inflammatory diseases, tumors and menstrual pain. However, its pharmacological activity remains unclear. In this study we evalua...
Antitumor and Apoptosis Induction Effects of Paeonol on Mice Bearing EMT6 Breast Carcinoma [0.03%]
丹皮酚的抗肿瘤及诱导小鼠EMT6乳腺癌细胞凋亡作用
Yetao Ou,Qingwang Li,Jianjie Wang et al.
Yetao Ou et al.
Paeonol is a major phenolic micromolecular component of Moutan cortex Radicis, a traditional Chinese Medicine. It has shown antitumor effects in previous studies; however, the underlying mechanisms remain unknown. This study investigated th...