Tolfenamic Acid Suppresses Inflammatory Stimuli-Mediated Activation of NF-κB Signaling [0.03%]
托酚酸通过抑制NF-κB信号转导途径活性而发挥抗炎作用
Hong Jun Shao,Zhiyuan Lou,Jin Boo Jeong et al.
Hong Jun Shao et al.
Tolfenamic acid (TA) is a traditional non-steroid anti-inflammatory drug (NSAID) and has been broadly used for the treatment of migraines. Nuclear factor kappa B (NF-κB) is a sequence-specific transcription factor and plays a key role in t...
The Histone Deacetylase Inhibitor Trichostatin A Sensitizes Human Renal Carcinoma Cells to TRAIL-Induced Apoptosis through Down-Regulation of c-FLIPL [0.03%]
组蛋白去乙酰化酶抑制剂曲古菌素A通过下调c-FLIPL提高人类肾癌细胞对TRAIL诱导的凋亡的敏感性
Min Ho Han,Cheol Park,Taek Kyu Kwon et al.
Min Ho Han et al.
Histone acetylation plays a critical role in the regulation of transcription by altering the structure of chromatin, and it may influence the resistance of some tumor cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (T...
Atractylochromene Is a Repressor of Wnt/β-Catenin Signaling in Colon Cancer Cells [0.03%]
白术内酯烯通过抑制Wnt/β-catenin信号通路诱导结肠癌细胞的凋亡
Ah-Ram Shim,Guang-Zhi Dong,Hwa Jin Lee et al.
Ah-Ram Shim et al.
Wnt/β-catenin signaling pathway was mutated in about 90% of the sporadic and hereditary colorectal cancers. The abnormally activated β-catenin increases the cancer cell proliferation, differentiation and metastasis through increasing the ...
Thymosin Beta-4, Actin-Sequestering Protein Regulates Vascular Endothelial Growth Factor Expression via Hypoxia-Inducible Nitric Oxide Production in HeLa Cervical Cancer Cells [0.03%]
甲状腺素β-4，肌动蛋白封存蛋白通过缺氧诱导的一氧化氮产生调节血管内皮生长因子在HeLa宫颈癌细胞中的表达
Yun-Kyoung Ryu,Jae-Wook Lee,Eun-Yi Moon
Yun-Kyoung Ryu
Vascular endothelial growth factor (VEGF) is an important regulator of neovascularization. Hypoxia inducible nitric oxide (NO) enhanced the expression of VEGF and thymosin beta-4 (Tβ4), actin sequestering protein. Here, we investigated whe...
Keratinocytic vascular endothelial growth factor as a novel biomarker for pathological skin condition [0.03%]
角蛋白血管内皮生长因子作为病理皮肤状况的新型生物标志物
Ok-Nam Bae,Minsoo Noh,Young-Jin Chun et al.
Ok-Nam Bae et al.
Skin is an emerging target tissue in pharmaceutical and cosmetic science. Safety assessment for dermal toxicity is a critical step for development of topically applicable pharmaceutical agents and ingredients in cosmetics. Urgent needs exis...
Promising pharmacological directions in the world of lysophosphatidic Acid signaling [0.03%]
磷脂酸信号通路的药物研究新方向
Nicole C Stoddard,Jerold Chun
Nicole C Stoddard
Lysophosphatidic acid (LPA) is a signaling lipid that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. These receptors initiate signaling cascades relevant to development, maintenance, and healing processes throu...
Effects of electromagnetic radiation exposure on stress-related behaviors and stress hormones in male wistar rats [0.03%]
电磁辐射暴露对雄性Wistar大鼠应激相关行为及应激激素的影响
Seyed Mohammad Mahdavi,Hedayat Sahraei,Parichehreh Yaghmaei et al.
Seyed Mohammad Mahdavi et al.
Studies have demonstrated that electromagnetic waves, as the one of the most important physical factors, may alter cognitive and non-cognitive behaviors, depending on the frequency and energy. Moreover, non-ionizing radiation of low energy ...
Evaluation of Osseointegration around Tibial Implants in Rats by Ibandronate-Treated Nanotubular Ti-32Nb-5Zr Alloy [0.03%]
评价伊班磷酸盐处理的钛合金纳米管层对大鼠骨整合的影响
Manoj Nepal,Liang Li,Tae Sung Bae et al.
Manoj Nepal et al.
Materials with differing surfaces have been developed for clinical implant therapy in dentistry and orthopedics. This study was designed to evaluate bone response to titanium alloy containing Ti-32Nb-5Zr with nanostructure, anodic oxidation...
Dependence potential of tramadol: behavioral pharmacology in rodents [0.03%]
tramadol依赖性：实验动物的行为药理学研究
Hye Jin Cha,Min Ji Song,Kwang-Wook Lee et al.
Hye Jin Cha et al.
Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this stud...
Protective Effects of Verapamil against H2O2-Induced Apoptosis in Human Lens Epithelial Cells [0.03%]
维拉帕米对H₂O₂诱导的人晶状上皮细胞凋亡的抑制作用
Zhuo Wang,Dan Wang,Yan Li et al.
Zhuo Wang et al.
Verapamil is used in the treatment of hypertension, angina pectoris, and atrial fibrillation. Recently, several studies have demonstrated that verapamil increased the optic nerve head blood flow and improved the retrobulbar circulation. All...