Inhibitory Effect of 3-(4-Hydroxyphenyl)-1-(thiophen-2-yl) prop-2-en-1-one, a Chalcone Derivative on MCP-1 Expression in Macrophages via Inhibition of ROS and Akt Signaling [0.03%]
3-(4-羟基苯基)-1-(噻吩-2-基)丙-2-烯-1-酮（查耳酮衍生物）通过抑制ROS和Akt信号抑制单核细胞趋化蛋白-1在巨噬细胞中的表达
Mi Jin Kim,Taraman Kadayat,Yeon Ji Um et al.
Mi Jin Kim et al.
Chalcones (1,3-diaryl-2-propen-1-ones), a subfamily of flavonoid, are widely known to possess potent anti-inflammatory and anti-oxidant properties. In this study, we investigated the effect of 3-(4-Hydroxyphenyl)-1-(thio3-(4-Hydroxyphenyl p...
Shikonin Isolated from Lithospermum erythrorhizon Downregulates Proinflammatory Mediators in Lipopolysaccharide-Stimulated BV2 Microglial Cells by Suppressing Crosstalk between Reactive Oxygen Species and NF-κB [0.03%]
从紫草科植物中分离的 Sho 酮通过抑制活性氧和NF-kappa B之间的相互作用来下调脂多糖刺激的小胶质细胞BV2中的促炎症介质
Rajapaksha Gedara Prasad,Yung Hyun Choi,Gi-Young Kim
Rajapaksha Gedara Prasad
According to the expansion of lifespan, neuronal disorder based on inflammation has been social problem. Therefore, we isolated shikonin from Lithospermum erythrorhizon and evaluated anti-inflammatory effects of shikonin in lipopolysacchari...
Cancer metabolism: strategic diversion from targeting cancer drivers to targeting cancer suppliers [0.03%]
癌症代谢：战略转向针对供应癌细胞的靶点而非驱动癌细胞生长的靶点
Soo-Youl Kim
Soo-Youl Kim
Drug development groups are close to discovering another pot of gold-a therapeutic target-similar to the success of imatinib (Gleevec) in the field of cancer biology. Modern molecular biology has improved cancer therapy through the identifi...
Anti-Inflammatory Effects of Water Chestnut Extract on Cytokine Responses via Nuclear Factor-κB-signaling Pathway [0.03%]
中国莲藕提取物抗炎作用及其对细胞因子反应和核转录因子NF-κB信号途径的影响
Bora Kim,Jin Eun Kim,Byung-Kook Choi et al.
Bora Kim et al.
Water chestnut (Trapa japonica Flerov.) is an annual aquatic plant. In the present study, we showed that the treatment of water chestnut extracted with boiling water resulted in a significant increase 2,2-diphenyl-1-picrylhydrazyl (DPPH) ra...
7α-Hydroxycholesterol Elicits TLR6-Mediated Expression of IL-23 in Monocytic Cells [0.03%]
7α-羟基胆固醇通过TLR6介导的单核细胞中IL-23表达
Hyun Chul Seo,Sun-Mi Kim,Seong-Kug Eo et al.
Hyun Chul Seo et al.
We investigated the question of whether 7-oxygenated cholesterol derivatives could affect inflammatory and/or immune responses in atherosclerosis by examining their effects on expression of IL-23 in monocytic cells. 7α-Hydroxycholesterol (...
Genistein from Vigna angularis Extends Lifespan in Caenorhabditis elegans [0.03%]
从棱角扁豆中提取的genistein延长了线虫的生命期
Eun Byeol Lee,Dalrae Ahn,Ban Ji Kim et al.
Eun Byeol Lee et al.
The seed of Vigna angularis has long been cultivated as a food or a folk medicine in East Asia. Genistein (4',5,7-trihydroxyisoflavone), a dietary phytoestrogen present in this plant, has been known to possess various biological properties....
Ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, inhibits proliferation and differentiation of th17 cells [0.03%]
过氧化物酶体增殖活化受体γ配体 ciglitazone 抑制 Th17 细胞的增值和分化
Dong Hyeok Kim,Hyun-Ju Ihn,Chaerin Moon et al.
Dong Hyeok Kim et al.
Peroxisome proliferator-activated receptor gamma (PPARγ) was identified as a cell-intrinsic regulator of Th17 cell differentiation. Th17 cells have been associated with several autoimmune diseases, including experimental autoimmune encepha...
Effect of Cordycepin-Enriched WIB801C from Cordyceps militaris Suppressing Fibrinogen Binding to Glycoprotein IIb/IIIa [0.03%]
虫草素富集的WIB801C抑制纤维蛋白原与糖蛋白IIb/IIIa结合的作用研究
Dong-Ha Lee,Hyun-Hong Kim,Deok Hwi Lim et al.
Dong-Ha Lee et al.
In this study, we investigated the effects of cordycepin-enriched (CE)-WIB801C, a n-butanol extract of Cordyceps militaris-hypha on collagen-stimulated platelet aggregation. CE-WIB801C dose dependently inhibited collagen-induced platelet ag...
Protective Effect of Liriodendrin Isolated from Kalopanax pictus against Gastric Injury [0.03%]
东京黄柏中分离得到的白莲润酮对胃损伤的保护作用
Yoon Ah Sohn,Seon A Hwang,Sun Yi Lee et al.
Yoon Ah Sohn et al.
In this study, we investigated the inhibitory activities on gastritis and gastric ulcer using liriodendrin which is a constituent isolated from Kalopanax pictus. To elucidate its abilities to prevent gastric injury, we measured the quantity...
Therapeutic effects of s-petasin on disease models of asthma and peritonitis [0.03%]
化感柴胡素治疗哮喘和腹膜炎模型的疗效研究
Kyoung-Pil Lee,Saeromi Kang,Min-Soo Noh et al.
Kyoung-Pil Lee et al.
To explore the anti-allergic and anti-inflammatory effects of extracts of Petasites genus, we studied the effects of s-petasin, a major sesquiterpene from Petasites formosanus (a butterbur species) on asthma and peritonitis models. In an ov...