Effect of methotrexate on collagen-induced arthritis assessed by micro-computed tomography and histopathological examination in female rats [0.03%]
甲氨蝶呤对胶原诱导型 arthritis的效应评价：micro-CT和病理学分析小鼠性别差异的影响
Young Hee Kim,Jin Seok Kang
Young Hee Kim
We tested the hypothesis that micro-computed tomography (micro-CT) analysis provides a better quantitative readout of the therapeutic potential of methotrexate (MTX) for treating collagen-induced arthritis (CIA) in rats and compared to conv...
Functional Significance of Cytochrome P450 1A2 Allelic Variants, P450 1A2*8, *15, and *16 (R456H, P42R, and R377Q) [0.03%]
细胞色素P450 1A2突变体P450 1A2*8、*15和*16（R456H，P42R和R377Q）的功能意义
Young-Ran Lim,In-Hyeok Kim,Songhee Han et al.
Young-Ran Lim et al.
P450 1A2 is responsible for the metabolism of clinically important drugs and the metabolic activation of environmental chemicals. Genetic variations of P450 1A2 can influence its ability to perform these functions, and thus, this study aime...
Diallyl Disulfide Prevents Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats through the Inhibition of Oxidative Damage, MAPKs, and NF-κB Pathways [0.03%]
二烯丙基二硫通过抑制氧化损伤、MAPK 和 NF-κB 通路预防大鼠环磷酰胺引起的出血性膀胱炎
Sung Hwan Kim,In Chul Lee,Je Won Ko et al.
Sung Hwan Kim et al.
This study investigated the possible effects and molecular mechanisms of diallyl disulfide (DADS) against cyclophosphamide (CP)-induced hemorrhagic cystitis (HC) in rats. Inflammation response was assessed by histopathology and serum cytoki...
Hair growth promoting potential of phospholipids purified from porcine lung tissues [0.03%]
从猪肺组织中提取的磷脂促进头发生长的作用研究
Seong-Hyun Choi,Jeong-Su Moon,Byung-Suk Jeon et al.
Seong-Hyun Choi et al.
BP201, porcine lung tissue-derived phospholipids, consists of phosphatidylcholine as a major phospholipid species. BP201 promoted hair growth after application onto the shaved backs of BALB/c and C3H mice. Its effect was enhanced when appli...
Galangin (3,5,7-trihydroxyflavone) shields human keratinocytes from ultraviolet B-induced oxidative stress [0.03%]
牻牛儿芽素通过保护人类角质细胞免受紫外线B诱导的氧化应激反应而产生光保护作用
Susara Ruwan Kumara Madduma Hewage,Mei Jing Piao,Ki Cheon Kim et al.
Susara Ruwan Kumara Madduma Hewage et al.
Most skin damage caused by ultraviolet B (UVB) radiation is owing to the generation of reactive oxygen species. Phytochemicals can act as antioxidants against UVB-induced oxidative stress. This study investigated the protective effects of t...
Spinosin, a C-Glucosylflavone, from Zizyphus jujuba var. spinosa Ameliorates Aβ1-42 Oligomer-Induced Memory Impairment in Mice [0.03%]
刺槐素通过改善Aβ1-42低聚糖诱导的小鼠记忆损伤来发挥其潜在的抗阿尔茨海默病作用
Sang Yoon Ko,Hyung Eun Lee,Se Jin Park et al.
Sang Yoon Ko et al.
Alzheimer's disease (AD) is a neurodegenerative disorder associated with progressive memory loss and neuronal cell death. Although numerous previous studies have been focused on disease progression or reverse pathological symptoms, therapeu...
Inhibitory effects of yuzu and its components on human platelet aggregation [0.03%]
柠檬和其成分对人类血小板聚集的抑制作用
Tae-Ho Kim,Hye-Min Kim,Se Won Park et al.
Tae-Ho Kim et al.
Our previous study demonstrated that yuzu has an anti-platelet effect in rat blood. In the present study, we examined whether the anti-platelet effect of yuzu can be extended to human blood by investigating its ability to inhibit aggregatio...
Cardamonin Suppresses TGF-β1-Induced Epithelial Mesenchymal Transition via Restoring Protein Phosphatase 2A Expression [0.03%]
豆蔻酚通过恢复蛋白磷酸酶2A的表达来抑制TGF-β1诱导的上皮间质转化
Eun Ji Kim,Hyun Ji Kim,Mi Kyung Park et al.
Eun Ji Kim et al.
Epithelial mesenchymal transition (EMT) is the first step in metastasis and implicated in the phenotype of cancer stem cells. Therefore, understanding and controlling EMT, are essential to the prevention and cure of metastasis. In the prese...
ATF3 Mediates Anti-Cancer Activity of Trans-10, cis-12-Conjugated Linoleic Acid in Human Colon Cancer Cells [0.03%]
反式10，顺式12共轭亚油酸抗癌作用的介导者ATF3的研究
Kui-Jin Kim,Jihye Lee,Yeonhwa Park et al.
Kui-Jin Kim et al.
Conjugated linoleic acids (CLA) are a family of isomers of linoleic acid. CLA increases growth arrest and apoptosis of human colorectal cancer cells through an isomer-specific manner. ATF3 belongs to the ATF/CREB family of transcription fac...
The Cytotoxicity of Kahweol in HT-29 Human Colorectal Cancer Cells Is Mediated by Apoptosis and Suppression of Heat Shock Protein 70 Expression [0.03%]
咖啡醇通过诱导HT-29人结肠直肠癌细胞凋亡及抑制热休素HSP70表达而发挥细胞毒性作用
Dong Wook Choi,Man Sup Lim,Jae Won Lee et al.
Dong Wook Choi et al.
Although coffee is known to have antioxidant, anti-inflammatory, and antitumor properties, there have been few reports about the effect and mechanism of coffee compounds in colorectal cancer. Heat shock proteins (HSPs) are molecular chapero...