Treatment of GABA from Fermented Rice Germ Ameliorates Caffeine-Induced Sleep Disturbance in Mice [0.03%]
发芽稻谷发酵产物GABA对咖啡引起的睡眠障碍的治疗作用
Darine Froy N Mabunga,Edson Luck T Gonzales,Hee Jin Kim et al.
Darine Froy N Mabunga et al.
γ-Aminobutyric acid (GABA), a major inhibitory neurotransmitter in the mammalian central nervous system, is involved in sleep physiology. Caffeine is widely used psychoactive substance known to induce wakefulness and insomnia to its consum...
Effect of pioglitazone on excitotoxic neuronal damage in the mouse hippocampus [0.03%]
吡格列酮对小鼠海马兴奋毒性神经元损伤的影响
Choong Hyun Lee,Min-Hee Yi,Dong Jin Chae et al.
Choong Hyun Lee et al.
Pioglitazone (PGZ), a synthetic peroxisome proliferator-activated receptor γ agonist, is known to regulate inflammatory process and to have neuroprotective effects against neurological disorders. In the present study, we examined the effec...
Repeated neonatal propofol administration induces sex-dependent long-term impairments on spatial and recognition memory in rats [0.03%]
重复的新生大鼠丙泊酚给药诱导与性别相关的长期空间和识别记忆损伤
Edson Luck T Gonzales,Sung Min Yang,Chang Soon Choi et al.
Edson Luck T Gonzales et al.
Propofol is an anesthetic agent that gained wide use because of its fast induction of anesthesia and rapid recovery post-anesthesia. However, previous studies have reported immediate neurodegeneration and long-term impairment in spatial lea...
Protective effects of silibinin and its possible mechanism of action in mice exposed to chronic unpredictable mild stress [0.03%]
持续不可预测的轻度应激小鼠中水飞蓟素的保护作用及其可能的作用机制
Wen-Jing Yan,Ying-Chun Tan,Ji-Cheng Xu et al.
Wen-Jing Yan et al.
Silibinin, a natural flavonoid antioxidant isolated from extracts of the milk thistle herb, has recently been identified as having anti-hepatotoxic and anticancer properties. In this paper, we investigated the effects of silibinin on behavi...
Dieckol, a Component of Ecklonia cava, Suppresses the Production of MDC/CCL22 via Down-Regulating STAT1 Pathway in Interferon-γ Stimulated HaCaT Human Keratinocytes [0.03%]
紫菜多糖中的dieckol通过下调干扰素-γ刺激的人皮肤角质形成细胞中的STAT1通路抑制MDC / CCL22的生成
Na-Jin Kang,Dong-Hwan Koo,Gyeoung-Jin Kang et al.
Na-Jin Kang et al.
Macrophage-derived chemokine, C-C motif chemokine 22 (MDC/CCL22), is one of the inflammatory chemokines that controls the movement of monocytes, monocyte-derived dendritic cells, and natural killer cells. Serum and skin MDC/CCL22 levels are...
The inhibitory effect of shikonin on the agonist-induced regulation of vascular contractility [0.03%]
虾青素对激动剂诱导的血管收缩调节的抑制作用
Hyun Dong Je,Hyeong-Dong Kim,Hyen-Oh La
Hyun Dong Je
Shikonin, a natural flavonoid found in the roots of Lithospermum erythrorhizon, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of shikonin on vascular smooth muscle contrac...
Antitumor Effects of Fucoidan on Human Colon Cancer Cells via Activation of Akt Signaling [0.03%]
岩藻糖对人结肠癌细胞的抗肿瘤效应通过激活Akt信号路径实现
Yong-Seok Han,Jun Hee Lee,Sang Hun Lee
Yong-Seok Han
We identified a novel Akt signaling mechanism that mediates fucoidan-induced suppression of human colon cancer cell (HT29) proliferation and anticancer effects. Fucoidan treatment significantly inhibited growth, induced G1-phase-associated ...
A cannabinoid receptor agonist N-arachidonoyl dopamine inhibits adipocyte differentiation in human mesenchymal stem cells [0.03%]
大麻素受体激动剂N-花生四烯酸多巴胺抑制人骨髓间充质干细胞的脂肪细胞分化
Seyeon Ahn,Sodam Yi,Won Jong Seo et al.
Seyeon Ahn et al.
Endocannabinoids can affect multiple cellular targets, such as cannabinoid (CB) receptors, transient receptor potential cation channel, subfamily V, member 1 (TRPV1) and peroxisome proliferator-activated receptor γ (PPARγ). The stimuli to...
Kyungho Park
Kyungho Park
Skin is the first line of defense for protecting our bodies against external perturbations, including ultraviolet (UV) irradiation, mechanical/chemical stress, and bacterial infection. Nutrition is one of many factors required for the maint...
Keumhan Noh,Mahesh Raj Nepal,Ki Sun Jeong et al.
Keumhan Noh et al.
Scutellaria baicalensis is one of the most widely used herbal medicines in East Asia. Because baicalein and baicalin are major components of this herb, it is important to understand the effects of these compounds on drug metabolizing enzyme...