Liposomal Hyaluronic Acid Enhances Skin Permeation and Hydration: Evidence from In Vitro, Ex Vivo, and In Vivo Studies [0.03%]
liposome传输透明质酸促进皮肤渗透及保湿作用的证据：体外，离体及体内研究
Jeong Mi Lee,Young Hun Hwang,Bo Mi Park et al.
Jeong Mi Lee et al.
Topically applied hyaluronic acid (HA) hydrates the skin without efficient penetration. This study compared the penetration efficiency of liposomal hyaluronic acid (LPS-HA) against that of conventional HA across different models. Dynamic li...
CAR-Based Cell and Gene Therapies: Global Clinical Landscape and Emerging Therapeutic Strategies from ClinicalTrials.gov [0.03%]
基于CAR的细胞和基因疗法：全球临床格局及ClinicalTrials.gov中出现的治疗策略
Saerom Moon,Kyoung Song
Saerom Moon
Chimeric Antigen Receptor (CAR)-based cell and gene therapies have become transformative treatments, offering targeted and durable responses, especially in hematologic malignancies. This review analyzes 1,744 CAR clinical trials registered ...
Microglial PLXDC2 Modulates Aβ Phagocytosis and Inflammatory Responses [0.03%]
微胶质细胞PLXDC2调节Aβ吞噬作用和炎症反应
Yoonah R Oh,Se Eun Park,Hee Kyung Kim et al.
Yoonah R Oh et al.
Microglia have emerged as key regulators in Alzheimer's disease (AD), yet the molecular factors driving their dysfunction remain unclear. Through integrative transcriptomic and proteomic analyses, we identified PLXDC2, a transmembrane recep...
Sialyllactose Alleviates Streptozotocin-Induced Diabetes through Anti-Inflammatory and Metabolic Modulation [0.03%]
壳二糖乳糖通过抗炎和代谢调节治疗链脲佐菌素诱导的糖尿病
Phuc Nguyen Tran-Duc,Sohyun Sim,Yujin Jin et al.
Phuc Nguyen Tran-Duc et al.
Diabetes mellitus (DM) is a disorder characterized by hyperglycemia, inflammation, and impaired metabolic activities. This study investigated the effects of sialyllactose (SL), a subgroup of human milk oligosaccharides, on streptozotocin (S...
Ursodeoxycholic Acid Attenuates B Cell Susceptibility to SARS-CoV-2 Spike Protein by Interfering Its Binding to ACE2 [0.03%]
熊去氧胆酸通过干扰S蛋白与ACE2结合抑制B细胞的新冠病毒易感性
So-Jeong Park,Eun-Yi Moon
So-Jeong Park
B cells are essential for the defense against various infectious agents including severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) causing coronavirus disease 2019 (COVID-19). COVID-19 is caused by interaction of the spike prote...
Corylin Exhibits Anticancer Activity by Inducing Apoptosis and G0/G1 Cell Cycle Arrest in SKOV3 Human Ovarian Cancer Cells [0.03%]
金雀异黄素通过诱导SKOV3人卵巢癌细胞凋亡和G0 / G1期细胞周期停滞而发挥抗肿瘤活性
Huiwon No,Jungeun Kim,Jin-Kyung Kim
Huiwon No
Ovarian cancer is the leading cause of death among gynecological malignancies worldwide. Surgery and chemotherapy are the primary treatment modalities; however, their effectiveness significantly diminishes in the advanced stages of the dise...
Involvement of the DNA Demethylase Thymine DNA Glycosylase in Anticancer Drug Resistance [0.03%]
胸腺嘧啶DNA甘露糖酶在抗癌症药物耐药中的作用
Kyoung Ah Kang,Mei Jing Piao,Herath Mudiyanselage Maheshika Madhuwanthi Senavirathna et al.
Kyoung Ah Kang et al.
Anticancer drug resistance remains a significant challenge to the efficacy of cancer treatment, with DNA repair enzymes contributing to this resistance. We hypothesized that thymine DNA glycosylases (TDGs) may be involved in anticancer drug...
Glucose-Enhanced Cryopreservation of hCAR-T Cells: Improved Recovery and Reduced Apoptosis [0.03%]
葡萄糖增强的hCAR-T细胞冷冻保存法：改善复苏效果和减少细胞凋亡
Sang-Eun Jung,Youngchae Moon,Minji Lim et al.
Sang-Eun Jung et al.
Human chimeric antigen receptor T (hCAR-T) cells are highly potent cellular therapeutics, but their clinical utility depends on stable long-term preservation due to high production costs and lengthy manufacturing processes. Cryopreservation...
Gnetofuran A Enhances Osteoblast Differentiation through the p38 Signaling Pathway [0.03%]
吉内素A通过p38信号途径促进成骨细胞分化
Meiyu Piao,Lulu Yao,SeonJu Park et al.
Meiyu Piao et al.
Gnetofuran A, a newly extracted compound from Gnetum latifolium, possesses anti-inflammatory effects by inhibiting TNF-α activity. However, the function and mechanism of Gnetofuran A in osteoblast differentiation remain unknown. In this st...
N-Acetyldopamine Dimer from Cicadidae Periostracum Is Enantioselectively Neuroprotective via Antioxidant Property [0.03%]
拟青霉素A的对映异构体通过抗氧化特性选择性地保护神经细胞
Punam Thapa,Shristi Khanal,Kibria Gulam et al.
Punam Thapa et al.
N-Acetyldopamine oligomers are typically biosynthesized as racemic mixtures, yet enantiomers can differ markedly in pharmacological efficacy and safety. In this study, we isolated a pair of enantiomers of an N-acetyldopamine dimer (compound...