Anti-Proliferative Effect of Naringenin through p38-Dependent Downregulation of Cyclin D1 in Human Colorectal Cancer Cells [0.03%]
芸香素通过依赖p38的细胞周期蛋白d1下调抑制人类结直肠癌细胞增殖
Hun Min Song,Gwang Hun Park,Hyun Ji Eo et al.
Hun Min Song et al.
Naringenin (NAR) as one of the flavonoids observed in grapefruit has been reported to exhibit an anti-cancer activity. However, more detailed mechanism by which NAR exerts anti-cancer properties still remains unanswered. Thus, in this study...
Chitin from Cuttlebone Activates Inflammatory Cells to Enhance the Cell Migration [0.03%]
墨鱼骨几丁质激活炎症细胞从而增强细胞迁移的能力
Sung Cil Lim,Ki-Man Lee,Tae Jin Kang
Sung Cil Lim
Our previous report showed that the extract from cuttlebone (CB) had wound healing effect in burned lesion of rat and the extract was identified as chitin by HPLS analysis. We herein investigated the morphology in CB extract using scanning ...
Autophagy Regulates Formation of Primary Cilia in Mefloquine-Treated Cells [0.03%]
甲氟喹处理细胞中自噬通过调节主纤毛的形成来影响药物敏感性
Ji Hyun Shin,Dong-Jun Bae,Eun Sung Kim et al.
Ji Hyun Shin et al.
Primary cilia have critical roles in coordinating multiple cellular signaling pathways. Dysregulation of primary cilia is implicated in various ciliopathies. To identify specific regulators of autophagy, we screened chemical libraries and i...
Induction of Resistance to BRAF Inhibitor Is Associated with the Inability of Spry2 to Inhibit BRAF-V600E Activity in BRAF Mutant Cells [0.03%]
Spry2抑制能力的丧失与BRAF突变细胞对BRAF抑制剂获得性耐药相关
Jun-Ho Ahn,Byeal-I Han,Michael Lee
Jun-Ho Ahn
The clinical benefits of oncogenic BRAF inhibitor therapies are limited by the emergence of drug resistance. In this study, we investigated the role of a negative regulator of the MAPK pathway, Spry2, in acquired resistance using BRAF inhib...
An Aminopropyl Carbazole Derivative Induces Neurogenesis by Increasing Final Cell Division in Neural Stem Cells [0.03%]
一种氨基羰氨化合物通过增加神经干细胞最终细胞分裂诱导神经发生
Jae-Yeon Shin,Sun-Young Kong,Hye Jin Yoon et al.
Jae-Yeon Shin et al.
P7C3 and its derivatives, 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(p-tolylamino)propan-2-ol (1) and N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-hydroxypropyl)-N-(3-methoxyphenyl)-4-methylbenzenesulfonamide (2), were previously reported to increase neu...
Phosphorylation and Reorganization of Keratin Networks: Implications for Carcinogenesis and Epithelial Mesenchymal Transition [0.03%]
角蛋白网络的磷酸化和重组：对癌变及上皮间质转化的意义
Hyun Ji Kim,Won Jun Choi,Chang Hoon Lee
Hyun Ji Kim
Metastasis is one of hallmarks of cancer and a major cause of cancer death. Combatting metastasis is highly challenging. To overcome these difficulties, researchers have focused on physical properties of metastatic cancer cells. Metastatic ...
Preclinical Pharmacokinetic Evaluation of β-Lapachone: Characteristics of Oral Bioavailability and First-Pass Metabolism in Rats [0.03%]
β- Lapachone的临床前药代动力学评估：口服生物利用度和首次通过代谢在大鼠中的特点
Iksoo Kim,Hyeongmin Kim,Jieun Ro et al.
Iksoo Kim et al.
β-Lapachone has drawn increasing attention as an anti-inflammatory and anti-cancer drug. However, its oral bioavailability has not been yet assessed, which might be useful to develop efficient dosage forms possibly required for non-clinica...
Defensive Behavior against Noxious Heat Stimuli Is Declined with Aging Due to Decreased Pain-Associated Gene Expression in Drosophila [0.03%]
由于果蝇与疼痛相关的基因表达减少，随着年龄的增长，其对有害热刺激的防御行为下降
Saurav Ghimire,Man Su Kim
Saurav Ghimire
Aging is defined as a collective process that alters organism's functional capacity and appearance over the course of life. Apart from an increase in susceptibility to many diseases, aging affects the cellular system that is responsible for...
Phenolic Compounds from the Leaves of Stewartia pseudocamellia Maxim. and their Whitening Activities [0.03%]
Stewartia pseudocamellia Maxim叶中的酚类化合物及其美白活性
Hyun Jung Roh,Hye-Ji Noh,Chun Su Na et al.
Hyun Jung Roh et al.
The half-dried leaves of Stewartia. pseudocamellia were extracted with hot water (SPE) and partitioned with n-hexane (SPEH), dichloromethane (SPED), and ethyl acetate (SPEE) successively. SPE and SPEE showed significant inhibitory effects a...
Neuroprotective and antioxidant effects of novel benzofuran-2-carboxamide derivatives [0.03%]
新型苯并呋喃-2-羧酰胺衍生物的神经保护和抗氧化作用
Jungsook Cho,Chowee Park,Youngmun Lee et al.
Jungsook Cho et al.
In the present study, we synthesized a series of novel 7-methoxy-N-(substituted phenyl)benzofuran-2-carboxamide derivatives in moderate to good yields and evaluated their neuroprotective and antioxidant activities using primary cultured rat...