Paraquat Induces Apoptosis through a Mitochondria-Dependent Pathway in RAW264.7 Cells [0.03%]
百草枯通过依赖线粒体的途径诱导RAW264.7细胞凋亡
Yeo Jin Jang,Jong Hoon Won,Moon Jung Back et al.
Yeo Jin Jang et al.
Paraquat dichloride (N,N-dimethyl-4-4'-bipiridinium, PQ) is an extremely toxic chemical that is widely used in herbicides. PQ generates reactive oxygen species (ROS) and causes multiple organ failure. In particular, PQ has been reported to ...
Role of miR-511 in the Regulation of OATP1B1 Expression by Free Fatty Acid [0.03%]
miR-511在游离脂肪酸调节OATP1B1表达中的作用
Jin Fu Peng,Li Liu,Cheng Xian Guo et al.
Jin Fu Peng et al.
MicroRNAs (miRNAs) are a family of non-coding RNA that are able to adjust the expression of many proteins, including ATP-binding cassette transporter and organic cation transporter. We sought to evaluate the effect of miR-511 on the regulat...
Immortalization of Primary Keratinocytes and Its Application to Skin Research [0.03%]
人表皮角质形成细胞的永生化及其在皮肤研究中的应用
Moonju Choi,Choongho Lee
Moonju Choi
As a major component of the epidermal tissue, a primary keratinocyte has served as an essential tool not only for the study of pathogenesis of skin-related diseases but also for the assessment of potential toxicities of various chemicals us...
Jaesuk Yun,Eunyong Chung,Ki Hwan Choi et al.
Jaesuk Yun et al.
Sibutramine is an anorectic that has been banned since 2010 due to cardiovascular safety issues. However, counterfeit drugs or slimming products that include sibutramine are still available in the market. It has been reported that illegal s...
Evaluation of Eye Irritation Potential of Solid Substance with New 3D Reconstructed Human Cornea Model, MCTT HCE(TM) [0.03%]
新型三维重建人角膜模型MCTT HCE(TM)评估固体物质眼睛刺激潜力的研究
Won-Hee Jang,Kyoung-Mi Jung,Hye-Ri Yang et al.
Won-Hee Jang et al.
The eye irritation potential of drug candidates or pharmaceutical ingredients should be evaluated if there is a possibility of ocular exposure. Traditionally, the ocular irritation has been evaluated by the rabbit Draize test. However, rabb...
Effects of Resveratrol Supplementation on Oxidative Damage and Lipid Peroxidation Induced by Strenuous Exercise in Rats [0.03%]
白藜芦醇对高强度运动诱导的大鼠氧化损伤和脂质过氧化的影响
Ning-Ning Xiao
Ning-Ning Xiao
The purpose of the present study was to investigate the effects of resveratrol supplementation on oxidative damage and lipid peroxidation induced by strenuous exercise in rats. The rats were randomly divided into five groups: a sedentary co...
Pro-Apoptotic Activity of 4-Isopropyl-2-(1-Phenylethyl) Aniline Isolated from Cordyceps bassiana [0.03%]
源于棒束孢虫草的4-异丙基-2-(1-苯乙基)苯胺诱导肿瘤细胞凋亡的作用及机制研究
Mi Seon Kim,Yunmi Lee,Gi-Ho Sung et al.
Mi Seon Kim et al.
Cordyceps species including Cordyceps bassiana are a notable anti-cancer dietary supplement. Previously, we identified several compounds with anti-cancer activity from the butanol fraction (Cb-BF) of Cordyceps bassiana. To expand the struct...
Isorhamnetin Protects Human Keratinocytes against Ultraviolet B-Induced Cell Damage [0.03%]
山柰酚-3-芸香糖苷通过激活Nrf2/ARE通路保护人角质形成细胞免受紫外B损伤
Xia Han,Mei Jing Piao,Ki Cheon Kim et al.
Xia Han et al.
Isorhamnetin (3-methylquercetin) is a flavonoid derived from the fruits of certain medicinal plants. This study investigated the photoprotective properties of isorhamnetin against cell damage and apoptosis resulting from excessive ultraviol...
The Pharmacological Effects of Benachio-F(®) on Rat Gastrointestinal Functions [0.03%]
苯那 Bonuson-F 对大鼠胃肠功能的影响效应研究
Bijay Kumar Poudel,Jae Young Yu,Yong Sam Kwon et al.
Bijay Kumar Poudel et al.
Functional dyspepsia (FD) is a prevalent idiopathic upper gastrointestinal (GI) disorder characterized by diverse symptomatology including epigastric pain or discomfort, postprandial fullness, and early satiety. Although its pathophysiologi...
Anti-Influenza Activity of Betulinic Acid from Zizyphus jujuba on Influenza A/PR/8 Virus [0.03%]
酸枣仁中的鹅去氧皮素对流感病毒A/P俄亥俄州/8型的抑制作用
Eun-Hye Hong,Jae Hyoung Song,Kyo Bin Kang et al.
Eun-Hye Hong et al.
Betulinic acid, a pentacyclic triterpene isolated from Jujube tree (Zizyphus jujuba Mill), has been known for a wide range of biological and medicinal properties such as antibacterial, antimalarial, anti-inflammatory, antihelmintic, antinoc...