Peptidoglycan Up-Regulates CXCL8 Expression via Multiple Pathways in Monocytes/Macrophages [0.03%]
肽聚糖通过单核细胞/巨噬细胞中的多条途径上调CXCL8的表达
Chung Won Lee,Sung Woon Chung,Mi Ju Bae et al.
Chung Won Lee et al.
Peptidoglycan (PG), the gram positive bacterial pathogen-associated molecular patterns (PAMP), is detected in a high proportion in macrophage-rich atheromatous regions, and expression of chemokine CXCL8, which triggers monocyte arrest on ea...
Diphlorethohydroxycarmalol Suppresses Ultraviolet B-Induced Matrix Metalloproteinases via Inhibition of JNK and ERK Signaling in Human Keratinocytes [0.03%]
杜松茋通过抑制JNK和ERK信号转导阻断紫外线诱导的基质金属蛋白酶生成
Mei Jing Piao,Madduma Hewage Susara Ruwan Kumara,Ki Cheon Kim et al.
Mei Jing Piao et al.
Skin aging is the most readily observable process involved in human aging. Ultraviolet B (UVB) radiation causes photo-oxidation via generation of reactive oxygen species (ROS), thereby damaging the nucleus and cytoplasm of skin cells and ul...
Dimethyl Cardamonin Exhibits Anti-inflammatory Effects via Interfering with the PI3K-PDK1-PKCα Signaling Pathway [0.03%]
双甲基草寇素通过干扰磷脂酰肌醇-蛋白激酶D-蛋白 kinase Cα信号通路产生抗炎作用
Wan-Guo Yu,Hao He,Jing-Yun Yao et al.
Wan-Guo Yu et al.
Consumption of herbal tea [flower buds of Cleistocalyx operculatus (Roxb.) Merr. et Perry (Myrtaceae)] is associated with health beneficial effects against multiple diseases including diabetes, asthma, and inflammatory bowel disease. Emergi...
EP2 Induces p38 Phosphorylation via the Activation of Src in HEK 293 Cells [0.03%]
EP2通过激活Src诱导HEK 293细胞中p38磷酸化
Kyung-Soo Chun,Minsub Shim
Kyung-Soo Chun
Prostaglandin E2 (PGE2), a major product of cyclooxygenase, binds to four different prostaglandin E2 receptors (EP1, EP2, EP3, and EP4) which are G-protein coupled transmembrane receptors (GPCRs). Although GPCRs including EP receptors have ...
Simvastatin Reduces Lipopolysaccharides-Accelerated Cerebral Ischemic Injury via Inhibition of Nuclear Factor-kappa B Activity [0.03%]
辛伐他汀通过抑制核因子κB活性削弱脂多糖加速的脑缺血再灌注损伤作用
Angela M A Anthony Jalin,Jae-Chul Lee,Geum-Sil Cho et al.
Angela M A Anthony Jalin et al.
Preceding infection or inflammation such as bacterial meningitis has been associated with poor outcomes after stroke. Previously, we reported that intracorpus callosum microinjection of lipopolysaccharides (LPS) strongly accelerated the isc...
Vitamin C Stimulates Epidermal Ceramide Production by Regulating Its Metabolic Enzymes [0.03%]
维生素C通过调节其代谢酶刺激表皮丝氨酸生成
Kun Pyo Kim,Kyong-Oh Shin,Kyungho Park et al.
Kun Pyo Kim et al.
Ceramide is the most abundant lipid in the epidermis and plays a critical role in maintaining epidermal barrier function. Overall ceramide content in keratinocyte increases in parallel with differentiation, which is initiated by supplementa...
Pretreatment with Lycopene Attenuates Oxidative Stress-Induced Apoptosis in Human Mesenchymal Stem Cells [0.03%]
番茄红素预处理减轻氧化应激诱导的人间充质干细胞凋亡
Ji Yong Kim,Jai-Sung Lee,Yong-Seok Han et al.
Ji Yong Kim et al.
Human mesenchymal stem cells (MSCs) have been used in cell-based therapy to promote revascularization after peripheral or myocardial ischemia. High levels of reactive oxygen species (ROS) are involved in the senescence and apoptosis of MSCs...
Sang Hoon Joo
Sang Hoon Joo
In this review, lipid A, from its discovery to recent findings, is presented as a drug target and therapeutic molecule. First, the biosynthetic pathway for lipid A, the Raetz pathway, serves as a good drug target for antibiotic development....
Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted Cancer Therapeutics [0.03%]
抗体药物偶联物优化在靶向癌症治疗中的策略和进展
Eunhee G Kim,Kristine M Kim
Eunhee G Kim
Antibody-drug conjugates utilize the antibody as a delivery vehicle for highly potent cytotoxic molecules with specificity for tumor-associated antigens for cancer therapy. Critical parameters that govern successful antibody-drug conjugate ...
Measurement of Human Cytochrome P450 Enzyme Induction Based on Mesalazine and Mosapride Citrate Treatments Using a Luminescent Assay [0.03%]
基于美沙拉秦和马来酸曲美布汀给药的人CYP酶诱导效应的荧光检测方法
Young-Hoon Kim,Young-Ji Bae,Hyung Soo Kim et al.
Young-Hoon Kim et al.
Drug metabolism mostly occurs in the liver. Cytochrome P450 (CYP) is a drug-metabolizing enzyme that is responsible for many important drug metabolism reactions. Recently, the US FDA and EU EMA have suggested that CYP enzyme induction can b...