PXR Mediated Protection against Liver Inflammation by Ginkgolide A in Tetrachloromethane Treated Mice [0.03%]
银杏内酯A通过PXR介导的作用对抗四氯化碳所致小鼠肝炎的作用机制研究
Nanhui Ye,Hang Wang,Jing Hong et al.
Nanhui Ye et al.
The pregnane X receptor (PXR), a liver and intestine specific receptor,, has been reported to be related with the repression of inflammation as well as activation of cytochromosome P450 3A (CYP3A) expression. We examined the effect of PXR o...
Protopanaxatriol Ginsenoside Rh1 Upregulates Phase II Antioxidant Enzyme Gene Expression in Rat Primary Astrocytes: Involvement of MAP Kinases and Nrf2/ARE Signaling [0.03%]
原人参三醇型皂苷Rh1通过激活MAPKs/Nrf2信号通路上调初级星形胶质细胞二期抗氧化酶表达
Ji-Sun Jung,Sang-Yoon Lee,Dong-Hyun Kim et al.
Ji-Sun Jung et al.
Oxidative stress activates several intracellular signaling cascades that may have deleterious effects on neuronal cell survival. Thus, controlling oxidative stress has been suggested as an important strategy for prevention and/or treatment ...
Lobaric Acid Inhibits VCAM-1 Expression in TNF-α-Stimulated Vascular Smooth Muscle Cells via Modulation of NF-κB and MAPK Signaling Pathways [0.03%]
络石酸通过调节NF-κB和MAPK信号途径抑制TNF-α刺激的血管平滑肌细胞VCAM-1表达
Ii-Seul Kwon,Joung-Han Yim,Hong-Kum Lee et al.
Ii-Seul Kwon et al.
Lichens have been known to possess multiple biological activities, including anti-proliferative and anti-inflammatory activities. Vascular cell adhesion molecule-1 (VCAM-1) may play a role in the development of atherosclerosis. Hence, VCAM-...
Long Noncoding RNA MHRT Protects Cardiomyocytes against H2O2-Induced Apoptosis [0.03%]
长非编码RNA MHRT通过调控miR-34a/Sox6轴保护心肌细胞对抗H₂O₂诱导的凋亡作用
Jianying Zhang,Caihua Gao,Meijuan Meng et al.
Jianying Zhang et al.
Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide. The exploration of new biomarkers with high sensitivity and specificity for early diagnosis of AMI therefore becomes one of the primary task. In...
NDRG2 Expression Decreases Tumor-Induced Osteoclast Differentiation by Down-regulating ICAM1 in Breast Cancer Cells [0.03%]
NDRG2通过下调乳腺癌细胞中ICAM1的表达降低肿瘤诱导的破骨细胞分化
Bomi Kim,Sorim Nam,Ji Hyun Lim et al.
Bomi Kim et al.
Bone matrix is properly maintained by osteoclasts and osteoblasts. In the tumor microenvironment, osteoclasts are increasingly differentiated by the various ligands and cytokines secreted from the metastasized cancer cells at the bone metas...
Nan Wu,Mingyao Yang,Uma Gaur et al.
Nan Wu et al.
Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism. It is a nitrogen scavenger and a source of glutamate and glutamine that stimulates protein synthesis and i...
Hye Jin Cha,Yeon-Hee Seong,Min-Ji Song et al.
Hye Jin Cha et al.
Synthetic cannabinoids JWH-018 and JWH-250 in 'herbal incense' also called 'spice' were first introduced in many countries. Numerous synthetic cannabinoids with similar chemical structures emerged simultaneously and suddenly. Currently ther...
Assessment of the Abuse Liability of Synthetic Cannabinoid Agonists JWH-030, JWH-175, and JWH-176 [0.03%]
合成大麻素激动剂JWH-030、JWH-175和JWH-176的滥用倾向评估
Reinholdgher Tampus,Seong Shoon Yoon,June Bryan de la Peña et al.
Reinholdgher Tampus et al.
The emergence and use of synthetic cannabinoids have greatly increased in recent years. These substances are easily dispensed over the internet and on the streets. Some synthetic cannabinoids were shown to have abuse liability and were subs...
Lifespan Extending and Stress Resistant Properties of Vitexin from Vigna angularis in Caenorhabditis elegans [0.03%]
从大豆中提取的矢车菊素通过调节氧化还原平衡延长线虫寿命并提高其抗逆性
Eun Byeol Lee,Jun Hyeong Kim,Youn-Soo Cha et al.
Eun Byeol Lee et al.
Several theories emphasize that aging is closely related to oxidative stress and disease. The formation of excess ROS can lead to DNA damage and the acceleration of aging. Vigna angularis is one of the important medicinal plants in Korea. W...
Effect of Beta-Asarone on Impairment of Spatial Working Memory and Apoptosis in the Hippocampus of Rats Exposed to Chronic Corticosterone Administration [0.03%]
β-asarone对慢性皮质酮处理大鼠空间工作记忆障碍及海马神经元凋亡的影响
Bombi Lee,Bongjun Sur,Seong-Guk Cho et al.
Bombi Lee et al.
β-asarone (BAS) is an active component of Acori graminei rhizoma, a traditional medicine used clinically in treating dementia and chronic stress in Korea. However, the cognitive effects of BAS and its mechanism of action have remained elus...