Assessment of the Cytotoxic and Apoptotic Eἀects of Chaetominine in a Human Leukemia Cell Line [0.03%]
棒束孢素对人白血病细胞系的细胞毒和促凋亡作用评价
Jingyun Yao,Ruihua Jiao,Changqing Liu et al.
Jingyun Yao et al.
Chaetominine is a quinazoline alkaloid originating from the endophytic fungus Aspergillus fumigatus CY018. In this study, we showed evidence that chaetominine has cytotoxic and apoptotic effects on human leukemia K562 cells and investigated...
Quinpirole Increases Melatonin-Augmented Pentobarbital Sleep via Cortical ERK, p38 MAPK, and PKC in Mice [0.03%]
喹硫平通过鼠皮层ERK、p38MAPK和PKC增强五氯酚钠诱发的小鼠睡眠中的褪黑素反应
Sa-Ik Hong,Seung-Hwan Kwon,Ji-Young Hwang et al.
Sa-Ik Hong et al.
Sleep, which is an essential part of human life, is modulated by neurotransmitter systems, including gamma-aminobutyric acid (GABA) and dopamine signaling. However, the mechanisms that initiate and maintain sleep remain obscure. In this stu...
Min-Young Lee,Ki-Hoan Nam,Kyung-Chul Choi
Min-Young Lee
In Drosophila, rhomboid proteases are active cardinal regulators of epidermal growth factor receptor (EGFR) signaling pathway. iRhom1 and iRhom2, which are inactive homologs of rhomboid intramembrane serine proteases, are lacking essential ...
Long-Duration Three-Dimensional Spheroid Culture Promotes Angiogenic Activities of Adipose-Derived Mesenchymal Stem Cells [0.03%]
长时间三维球状体培养促进脂肪源性间充质干细胞的血管生成作用
Jun Hee Lee,Yong-Seok Han,Sang Hun Lee
Jun Hee Lee
Mesenchymal stem cells (MSCs) offer significant therapeutic promise for various regenerative therapies. However, MSC-based therapy for injury exhibits low efficacy due to the pathological environment in target tissues and the differences be...
Aspirin-Triggered Resolvin D1 Inhibits TGF-β1-Induced EndMT through Increasing the Expression of Smad7 and Is Closely Related to Oxidative Stress [0.03%]
阿司匹林触发的消退素D1通过增加Smad7的表达抑制TGF-β1诱导的内皮-间充质转化并与氧化应激密切相关
Yusheng Shu,Yu Liu,Xinxin Li et al.
Yusheng Shu et al.
The endothelial-mesenchymal transition (EndMT) is known to be involved in the transformation of vascular endothelial cells to mesenchymal cells. EndMT has been confirmedthat occur in various pathologic conditions. Transforming growth factor...
Won-Serk Kim,Ikyon Kim,Wang-Kyun Kim et al.
Won-Serk Kim et al.
Mitochondria-targeted vitamin E (MVE) is designed to accumulate within mitochondria and is applied to decrease mitochondrial oxidative damage. However, the protective effects of MVE in skin cells have not been identified. We investigated th...
Anthraquinone Glycoside Aloin Induces Osteogenic Initiation of MC3T3-E1 Cells: Involvement of MAPK Mediated Wnt and Bmp Signaling [0.03%]
大黄素苷 Aloin 诱导MC3T3-E1细胞成骨发生：MAPK介导的Wnt和BMP信号参与作用
Yutthana Pengjam,Harishkumar Madhyastha,Radha Madhyastha et al.
Yutthana Pengjam et al.
Osteoporosis is a bone pathology leading to increased fracture risk and challenging the quality of life. The aim of this study was to evaluate the effect of an anthraquinone glycoside, aloin, on osteogenic induction of MC3T3-E1 cells. Aloin...
Hesperidin Attenuates Ultraviolet B-Induced Apoptosis by Mitigating Oxidative Stress in Human Keratinocytes [0.03%]
芸香素通过缓解氧化应激抑制紫外线引起的角质形成细胞凋亡作用研究
Susara Ruwan Kumara Madduma Hewage,Mei Jing Piao,Kyoung Ah Kang et al.
Susara Ruwan Kumara Madduma Hewage et al.
Human skin cells undergo pathophysiological processes via generation of reactive oxygen species (ROS) upon excessive exposure to ultraviolet B (UVB) radiation. This study investigated the ability of hesperidin (C28H34O15) to prevent apoptos...
Naringenin-Mediated ATF3 Expression Contributes to Apoptosis in Human Colon Cancer [0.03%]
芸香苷通过诱导ATF3表达促进人类结肠癌细胞凋亡
Hun Min Song,Gwang Hun Park,Hyun Ji Eo et al.
Hun Min Song et al.
Naringenin (NAR) as one of the flavonoidsobserved in grapefruit has been reported to exhibit an anti-cancer activity. Activating transcription factor 3 (ATF3) is associated with apoptosis in human colon cancer cells. This study was performe...
Anti-Inflammatory Effect of Rosa rugosa Flower Extract in Lipopolysaccharide-Stimulated RAW264.7 Macrophages [0.03%]
玫瑰花提取物的抗炎作用及其对脂多糖刺激的小鼠RAW264.7巨噬细胞的影响
Xirali Tursun,Yongxin Zhao,Zulfiya Alat et al.
Xirali Tursun et al.
Rosa rugosa Thunb, a deciduous shrub of the genus Rosa, has been widely used to treat stomach aches, diarrhoea, pain, and chronic inflammatorydisease in eastern Asia. In recent years, our research team has extensively studied the Rosa rugos...