Cytisine, a Partial Agonist of α4β2 Nicotinic Acetylcholine Receptors, Reduced Unpredictable Chronic Mild Stress-Induced Depression-Like Behaviors [0.03%]
尼古丁乙酰胆碱受体的部分激动剂派替硫酸盐可降低慢性轻度不可预测性压力引起的类似抑郁的行为
Jing Han,Dong-Sheng Wang,Shui-Bing Liu et al.
Jing Han et al.
Cytisine (CYT), a partial agonist of α4β2-nicotinic receptors, has been used for antidepressant efficacy in several tests. Nicotinic receptors have been shown to be closely associated with depression. However, little is known about the ef...
Roles of Dopamine D₂ Receptor Subregions in Interactions with β-Arrestin2 [0.03%]
多巴胺D2受体亚区与β-arrestin2的作用机制及功能关系研究进展
Xiaohan Zhang,Bo-Gil Choi,Kyeong-Man Kim
Xiaohan Zhang
β-Arrestins are one of the protein families that interact with G protein-coupled receptors (GPCRs). The roles of β-arrestins are multifaceted, as they mediate different processes including receptor desensitization, endocytosis, and G prot...
Trichostatin A Protects Liver against Septic Injury through Inhibiting Toll-Like Receptor Signaling [0.03%]
特拉霍斯汀A通过抑制 toll 样受体信号途径保护肝脏免于脓毒伤损伤
So-Jin Kim,Jin-Sook Park,Do-Won Lee et al.
So-Jin Kim et al.
Sepsis, a serious clinical problem, is characterized by a systemic inflammatory response to infection and leads to organ failure. Toll-like receptor (TLR) signaling is intimately implicated in hyper-inflammatory responses and tissue injury ...
Anti-Proliferative and Pro-Apoptotic Activities of 4-Methyl-2,6-bis(1-phenylethyl)phenol in Cancer Cells [0.03%]
4-甲基-2,6-双（1-苯乙基）酚的抗增殖和促凋亡作用研究癌细胞中的作用研究
Nak Yoon Sung,Seung Cheol Kim,Yun Hwan Kim et al.
Nak Yoon Sung et al.
It has been found that 4-isopropyl-2,6-bis(1-phenylethyl)phenol (KTH-13), a novel compound isolated from Cordyceps bassiana, is able to suppress tumor cell proliferation by inducing apoptosis. To mass-produce this compound, we established a...
Inhibition of Wnt Signaling by Silymarin in Human Colorectal Cancer Cells [0.03%]
乳香素通过抑制Wnt信号通路途径诱导人结肠癌细胞 apoptosis
Hyun Ji Eo,Gwang Hun Park,Jin Boo Jeong
Hyun Ji Eo
Silymarin from milk thistle (Silybum marianum) has been reported to show an anti-cancer activity. In previous study, we reported that silymarin induces cyclin D1 proteasomal degradation through NF-κB-mediated threonine-286 phosphorylation....
The Anti-Inflammatory Activity of Eucommia ulmoides Oliv. Bark. Involves NF-κB Suppression and Nrf2-Dependent HO-1 Induction in BV-2 Microglial Cells [0.03%]
杜仲皮的抗炎作用涉及NF-κB抑制和Nrf2依赖性HO-1诱导在BV-2小胶质细胞中
Seung-Hwan Kwon,Shi-Xun Ma,Ji-Young Hwang et al.
Seung-Hwan Kwon et al.
In the present study, we investigated the anti-inflammatory properties of Eucommia ulmoides Oliv. Bark. (EUE) in lipopolysaccharide (LPS)-stimulated microglial BV-2 cells and found that EUE inhibited LPS-mediated up-regulation of pro-inflam...
Quercetin Directly Interacts with Vitamin D Receptor (VDR): Structural Implication of VDR Activation by Quercetin [0.03%]
檞皮素与维生素D受体直接相互作用：檞皮素激活维生素D受体的结构含义
Ki-Young Lee,Hye-Seung Choi,Ho-Sung Choi et al.
Ki-Young Lee et al.
The vitamin D receptor (VDR) is a member of the nuclear receptor (NR) superfamily. The VDR binds to active vitamin D3 metabolites, which stimulates downstream transduction signaling involved in various physiological activities such as calci...
Esculetin, a Coumarin Derivative, Inhibits Aldose Reductase Activity in vitro and Cataractogenesis in Galactose-Fed Rats [0.03%]
Esculetin（地枫皮素），一种香豆素衍生物，能够抑制体外和给鼠高剂量乳糖喂养情况下的己糖还原酶的活性及白内障病变
Chan-Sik Kim,Junghyun Kim,Yun Mi Lee et al.
Chan-Sik Kim et al.
Naturally occurring coumarin compounds have received substantial attention due to their pharmaceutical effects. Esculetin is a coumarin derivative and a polyphenol compound that is used in a variety of therapeutic and pharmacological strate...
Apigenin Regulates Interleukin-1β-Induced Production of Matrix Metalloproteinase Both in the Knee Joint of Rat and in Primary Cultured Articular Chondrocytes [0.03%]
阿皮基醇通过作用于膝关节及软骨细胞抑制IL-1β诱导的基质金属蛋白酶合成
Jin Sung Park,Dong Kyu Kim,Hyun-Dae Shin et al.
Jin Sung Park et al.
We examined whether apigenin affects the gene expression, secretion and activity of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as in vivo production of MMP-3 in the knee joint of rat to eva...
Comparative Evaluation of Hepatoprotective Activities of Geniposide, Crocins and Crocetin by CCl4-Induced liver Injury in Mice [0.03%]
三种藏红花肝保护成分的肝脏保护作用及其机制研究
Ping Chen,Yang Chen,Yarong Wang et al.
Ping Chen et al.
Iridoid glycosides (mainly geniposide) and crocetin derivatives (crocins) are the two major active constituents in Gardenia jasminoides Ellis. In the present study, geniposide, crocins, crocin-1 and crocetin were separated from gardenia chr...