Wogonin Attenuates Hippocampal Neuronal Loss and Cognitive Dysfunction in Trimethyltin-Intoxicated Rats [0.03%]
沃格苷抑制三甲基锡中毒大鼠海马神经元损失和认知功能障碍
Bombi Lee,Bongjun Sur,Seong-Guk Cho et al.
Bombi Lee et al.
We examined whether wogonin (WO) improved hippocampal neuronal activity, behavioral alterations and cognitive impairment, in rats induced by administration of trimethyltin (TMT), an organotin compound that is neurotoxic to these animals. Th...
Cognitive-Enhancing Effect of Dianthus superbus var. Longicalycinus on Scopolamine-Induced Memory Impairment in Mice [0.03%]
丹参素长萼变种对烟酰胺致小鼠认知障碍的影响
Jin Bae Weon,Youn Sik Jung,Choong Je Ma
Jin Bae Weon
Dianthus superbus (D. superbus) is a traditional crude drug used for the treatment of urethritis, carbuncles and carcinomas. The objective of this study was to confirm the cognitive enhancing effect of D. superbus in memory impairment induc...
Anti-Allergic Effect of Oroxylin A from Oroxylum indicum Using in vivo and in vitro Experiments [0.03%]
印度鸦趾树黄酮oroxylin A抗过敏作用的体内及体外实验研究
Ae-Yeon Lee,Saeromi Kang,Soo-Jin Park et al.
Ae-Yeon Lee et al.
Oroxylum indicum has long been used in Asian traditional medicine to prevent and treat respiratory diseases, diabetes, diarrhea and other conditions. Oroxylin A is a flavone that is present in Oroxylum indicum and in Scutellaria baicalensis...
Enhanced Expression of TREK-1 Is Related with Chronic Constriction Injury of Neuropathic Pain Mouse Model in Dorsal Root Ganglion [0.03%]
TREK-1在慢性约束损伤神经痛小鼠背根节中表达增强
Hyo Jo Han,Seung Wook Lee,Gyu-Tae Kim et al.
Hyo Jo Han et al.
Neuropathic pain is a complex state showing increased pain response with dysfunctional inhibitory neurotransmission. The TREK family, one of the two pore domain K⁺ (K2P) channel subgroups were focused among various mechanisms of neuropathi...
Blockade of STAT3 in T Cells Inhibits Germinal Center Reactions against Intranasal Allergens [0.03%]
T细胞STAT3信号阻断抑制鼻黏膜变应原的生发中心反应
Garam Choi,Yeonseok Chung
Garam Choi
Understanding the developmental mechanisms of humoral immunity against intranasal antigens is essential for the development of therapeutic approaches against air-borne pathogens as well as allergen-induced pulmonary inflammation. Follicular...
Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders [0.03%]
当前自闭症谱系障碍动物模型的临床和神经生物学意义
Ki Chan Kim,Edson Luck Gonzales,María T Lázaro et al.
Ki Chan Kim et al.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social and communication impairments, as well as repetitive and restrictive behaviors. The phenotypic heterogeneity of ASD has made it overwhelmingly difficult...
Keumhan Noh,Do Gyeong Oh,Mahesh Raj Nepal et al.
Keumhan Noh et al.
Pharmacokinetic interaction of chrysin, a flavone present in honey, propolis and herbs, with caffeine was investigated in male Sprague-Dawley rats. Because chrysin inhibited CYP1A-selective ethoxyresorufin O-deethylase and methoxyresorufin ...
Cytoprotective Mechanism of Cyanidin and Delphinidin against Oxidative Stress-Induced Tenofibroblast Death [0.03%]
花青素和飞燕草素通过抗氧化作用抑制氧化应激诱导的阴茎纤维肌肉和平滑肌细胞凋亡的机制研究
Dae Cheol Nam,Young Sool Hah,Jung Been Nam et al.
Dae Cheol Nam et al.
Age-related rotator cuff tendon degeneration is related to tenofibroblast apoptosis. Anthocyanins reduce oxidative stress-induced apoptotic cell death in tenofibroblasts. The current study investigated the presence of cell protective effect...
Differential Effects of Quercetin and Quercetin Glycosides on Human α7 Nicotinic Acetylcholine Receptor-Mediated Ion Currents [0.03%]
槲皮素和槲皮素糖苷对人α7烟碱乙酰胆碱受体介导的离子电流的差异性影响
Byung-Hwan Lee,Sun-Hye Choi,Hyeon-Joong Kim et al.
Byung-Hwan Lee et al.
Quercetin is a flavonoid usually found in fruits and vegetables. Aside from its antioxidative effects, quercetin, like other flavonoids, has a various neuropharmacological actions. Quercetin-3-O-rhamnoside (Rham1), quercetin-3-O-rutinoside ...
Columbianadin Inhibits Cell Proliferation by Inducing Apoptosis and Necroptosis in HCT116 Colon Cancer Cells [0.03%]
卡痛叶乙酸甲酯通过诱导HCT116结肠癌细胞凋亡和坏死受体依赖性 necroptosis 而抑制其增殖
Ji In Kang,Ji-Young Hong,Jae Sue Choi et al.
Ji In Kang et al.
Columbianadin (CBN), a natural coumarin from Angelica decursiva (Umbelliferae), is known to have various biological activities including anti-inflammatory and anti-cancer effects. In this study, the anti-proliferative mechanism of actions m...