Gapmer Antisense Oligonucleotide Targeting E-Cadherin Rescues Abnormal Keratinization in X-Linked Ichthyosis Models [0.03%]
针对X连锁鱼鳞病模型中异常角化的E-钙黏蛋白靶向Gapmer反义寡核苷酸的治疗作用研究
Ji Heung Kwak,Tae-Uk Kwon,Yeo-Jung Kwon et al.
Ji Heung Kwak et al.
X-linked ichthyosis (XLI) is an inherited disorder of keratinization resulting from a deficiency of steroid sulfatase (STS), for which no effective therapy is currently available. E-cadherin, a key upstream regulator of keratinocyte differe...
β-Catenin and AMPK/AKT/FOXO Signaling Mediate Doxorubicin-Induced Senescence and Lipid Accumulation in C2C12 Myoblasts [0.03%]
β-catenin和AMPK/AKT/FOXO信号转导介导阿霉素诱导的C2C12肌管细胞衰老及脂质蓄积
Chawon Yun,Sou Hyun Kim,Doyoung Kwon et al.
Chawon Yun et al.
Skeletal muscle atrophy is a major complication associated with aging, chronic disease, and chemotherapy. Doxorubicin (Dox), a widely used anticancer agent, accelerates muscle wasting; however, the underlying cellular mechanisms remain poor...
Integrating Robotic Bilateral Axillo-Breast Approach Thyroidectomy with Molecular Diagnostics and Artificial Intelligence in Thyroid Cancer Care [0.03%]
机器人双侧腋乳入路甲状腺手术与分子诊断和人工智能在甲状腺癌诊疗中的融合应用
Qiang Deng,Xiaoping Men,Duo Jin et al.
Qiang Deng et al.
Thyroid cancer is one of the most prevalent cancers in the world, accounting for the increased sensitivity of diagnostic assessments, the environment, and extensive imaging. While open thyroidectomy still forms the base surgical treatment o...
Curzerene Ameliorates Depression-Like Behaviors and Cognitive Impairment by Modulating the Gut Microbiota and HMGB1/RAGE/TLR4 Pathway [0.03%]
库尔策烯通过调节肠道微生物群和HMGB1/RAGE/TLR4信号通路改善抑郁样行为和认知障碍
Fengjing Huang,Xiaohong Ma,Xiao Xu et al.
Fengjing Huang et al.
Curzerene, a sesquiterpene compound isolated from Curcuma Radix, exhibits various therapeutic effects, such as anti-tumor and anti-hyperlipidemic properties. However, its neuroprotective effects have not yet been reported. This study focuse...
Roles of Wnt/β-Catenin Signaling in Osteoporosis, Disease Pathogenesis, and Natural Compound Intervention [0.03%]
Wnt/β-连环蛋白信号通路在骨质疏松发生发展及天然小分子干预中的作用
Li Cao,Jing Wang
Li Cao
Osteoblasts primarily originate from mesenchymal stem cells (MSCs) within the bone marrow. These stem cells possess the ability to differentiate into osteoblasts, which are responsible for secreting bone matrix, promoting bone formation, an...
Lycium Radicis Cortex and Its Kukoamine Constituents Attenuate Sarcopenia by Modulating Anabolic and Catabolic Pathways [0.03%]
枸杞根皮及番红素成分通过调节合成和分解代谢途径缓解肌肉减少症
Jae-Yong Kim,Rak Ho Son,Sang-Yoon Kim et al.
Jae-Yong Kim et al.
Lycium Radicis Cortex (LRC), derived from the root bark of Lycium chinense Mill., has traditionally been used in East Asian medicine to mitigate heat in the blood and consumptive fever. This study investigates LRC's effects on skeletal musc...
γ-Elemene Impairs Mitochondrial Biogenesis in Breast Cancer Cells by Upregulating GCN5-Mediated PGC-1α Acetylation [0.03%]
姜黄素类似物γ- elemene通过上调PGC-1α乙酰化来抑制乳腺癌细胞线粒体生物发生
Ling Tang,Mingyan Wang,Jia Liu et al.
Ling Tang et al.
Mitochondrial biogenesis represents a promising therapeutic target in triple-negative breast cancer (TNBC) due to its essential role in cancer cell metabolism and survival. The natural compound γ-Elemene exhibits potent anti-tumor activity...
Chrysoeriol Exerts Antiplatelet Effects by Regulating cAMP/cGMP and PI3K/MAPK Pathway [0.03%]
染料木素通过调节cAMP/cGMP和PI3K/MAPK信号通路产生抗血小板作用
Ga Hee Lee,Jin Pyo Lee,Akram Abdul Wahab et al.
Ga Hee Lee et al.
Chrysoeriol, a flavonoid naturally found in several plants, including Danggui Susan, a traditional herbal medicine, exhibits promising anti-inflammatory and antioxidant properties. Its potential to prevent cardiovascular diseases, primarily...
Erratum to "Mechanism of Action and Pharmacokinetics of Approved Bispecific Antibodies" [Biomol Ther 32(6), 708-722 (2024)] [0.03%]
关于“获批双特异性抗体的作用机制和药代动力学”[Biomol Ther 32(6), 708-722 (2024)]的勘误通知书
Seong Min Choi,Ju-Hee Lee,Soyeon Ko et al.
Seong Min Choi et al.
Published Erratum
Biomolecules & therapeutics. 2025 Nov 1;33(6):1085. DOI:10.4062/biomolther.2025.007 2025
DOT1L as a Therapeutic Target: Insights into Epigenetic Regulation and Cancer Treatment [0.03%]
DOT1L作为治疗靶点的启示：表观遗传调控与癌症治疗
Hee-Joo Choi,Minh Tuan Nguyen,Boram Kim et al.
Hee-Joo Choi et al.
Disruptor of Telomeric Silencing 1-Like (DOT1L) has emerged as a critical epigenetic regulator in cancer, primarily because of its role as the sole histone methyltransferase responsible for histone H3 at lysine 79 methylation. This modifica...