Komal Anjum,Syed Qamar Abbas,Sayed Asmat Ali Shah et al.
Komal Anjum et al.
Marine sponges have been considered as a drug treasure house with respect to great potential regarding their secondary metabolites. Most of the studies have been conducted on sponge's derived compounds to examine its pharmacological propert...
Calcium Signaling of Lysophosphatidylethanolamine through LPA1 in Human SH-SY5Y Neuroblastoma Cells [0.03%]
溶血磷脂酰乙醇胺通过LPA1诱导的人神经母细胞瘤SH-SY5Y细胞钙信号转导
Jung-Min Lee,Soo-Jin Park,Dong-Soon Im
Jung-Min Lee
Lysophosphatidylethanolamine (LPE), a lyso-type metabolite of phosphatidylethanolamine, has been reported to be an intercellular signaling molecule. LPE mobilizes intracellular Ca2+ through G-protein-coupled receptor (GPCR) in some cells ty...
Insulin as a Potent Stimulator of Akt, ERK and Inhibin-βE Signaling in Osteoblast-Like UMR-106 Cells [0.03%]
胰岛素是Akt、ERK和抑制素-βE信号在类似成骨细胞的UMR-106细胞中的强力刺激物
Mahesh Ramalingam,Yong-Dae Kwon,Sung-Jin Kim
Mahesh Ramalingam
Insulin is a peptide hormone of the endocrine pancreas and exerts a wide variety of physiological actions in insulin sensitive tissues, such as regulation of glucose homeostasis, cell growth, differentiation, learning and memory. However, t...
Antiplatelet and Antithrombotic Effects of the Extract of Lindera obtusiloba Leaves [0.03%]
尖叶厚朴叶提取物的抗血小板和抗凝作用研究
Jun Ho Kim,Jaemin Lee,Soouk Kang et al.
Jun Ho Kim et al.
Lindera obtusiloba has been used in traditional herbal medicine for the treatment of blood stasis and inflammation. The leaves of Lindera obtusiloba have been reported to exhibit various physiological activities. However, there is little in...
Anti-Inflammatory Properties of Flavone di-C-Glycosides as Active Principles of Camellia Mistletoe, Korthalsella japonica [0.03%]
日本檞寄生（Korthalsella japonica）中两种黄烷酮二-C-糖苷的抗炎活性研究
Min Kyoung Kim,Kwang Jun Yun,Da Hae Lim et al.
Min Kyoung Kim et al.
The chemical components and biological activity of Camellia mistletoe, Korthalsella japonica (Loranthaceae) are relatively unknown compared to other mistletoe species. Therefore, we investigated the phytochemical properties and biological a...
DW2007 Ameliorates Colitis and Rheumatoid Arthritis in Mice by Correcting Th17/Treg Imbalance and Inhibiting NF-κB Activation [0.03%]
DW2007通过纠正Th17/Treg失衡和抑制NF-κB活化来改善小鼠结肠炎和类风湿关节炎
Su-Min Lim,Sang-Yun Lee,Jin-Ju Jeong et al.
Su-Min Lim et al.
In the previous study, the rhizome mixture of Anemarrhena asphodeloides and Coptis chinensis (DW2007), improved TNBS-, oxazolone-, or DSS-induced colitis in mice by regulating macrophage activation. Therefore, to understand the effect of DW...
Hypericin, a Naphthodianthrone Derivative, Prevents Methylglyoxal-Induced Human Endothelial Cell Dysfunction [0.03%]
茋类衍生物超立新预防甲基甘油醛所致的人脐静脉内皮细胞功能障碍
Moon Ho Do,Sun Yeou Kim
Moon Ho Do
Methylglyoxal (MGO) is a highly reactive metabolite of glucose which is known to cause damage and induce apoptosis in endothelial cells. Endothelial cell damage is implicated in the progression of diabetes-associated complications and ather...
Quercetin-3- O- β-D-Glucuronide Suppresses Lipopolysaccharide-Induced JNK and ERK Phosphorylation in LPS-Challenged RAW264.7 Cells [0.03%]
檞皮素-3- O- β-D-葡萄糖醛酸苷通过抑制LPS诱导的RAW264.7细胞中JNK和ERK磷酸化发挥抗炎作用
Jin-Young Park,Man-Sup Lim,Song-In Kim et al.
Jin-Young Park et al.
Quercetin, a flavonol, has been reported to exhibit a wide range of biological properties including anti-oxidant and anti-inflammatory activities. However, pharmacological properties of quercetin-3-O-β-D-glucuronide (QG), a glycoside deriv...
Baicalein Protects Human Skin Cells against Ultraviolet B-Induced Oxidative Stress [0.03%]
黄芩素保护人皮肤细胞免受紫外线B诱导的氧化应激损伤
Min Chang Oh,Mei Jing Piao,Pattage Madushan Dilhara Jayatissa Fernando et al.
Min Chang Oh et al.
Baicalein (5,6,7-trihydroxy-2-phenyl-chromen-4-one) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis. This study evaluated the protective effects of baicalein against oxidative damage-mediated...
Shikonin Induces Apoptotic Cell Death via Regulation of p53 and Nrf2 in AGS Human Stomach Carcinoma Cells [0.03%]
Shocona通过调节p53和Nrf2诱导AGS人胃癌细胞的凋亡性细胞死亡
Hyeonseok Ko,Sun-Joong Kim,So Hee Shim et al.
Hyeonseok Ko et al.
Shikonin, which derives from Lithospermum erythrorhizon, has been traditionally used against a variety of diseases, including cancer, in Eastern Asia. Here we determined that shikonin inhibits proliferation of gastric cancer cells by induci...