Intranasal Administration of Interleukin-1 Receptor Antagonist in a Transient Focal Cerebral Ischemia Rat Model [0.03%]
经鼻给药IL-1受体拮抗剂对暂时性局灶性脑缺血大鼠的影响研究
Jae Hoon Lee,Eun Hee Kam,Jeong Min Kim et al.
Jae Hoon Lee et al.
The interleukin-1 receptor antagonist (IL-1RA) is a potential stroke treatment candidate. Intranasal delivery is a novel method thereby a therapeutic protein can be penetrated into the brain parenchyma by bypassing the blood-brain barrier. ...
Procaine Attenuates Pain Behaviors of Neuropathic Pain Model Rats Possibly via Inhibiting JAK2/STAT3 [0.03%]
普鲁卡因通过抑制JAK2/STAT3信号通路可能减轻坐骨神经损伤大鼠痛行为
Donghua Li,Yurong Yan,Lingzhi Yu et al.
Donghua Li et al.
Neuropathic pain (NPP) is the main culprit among chronic pains affecting the normal life of patients. Procaine is a frequently-used local anesthesia with multiple efficacies in various diseases. However, its role in modulating NPP has not b...
Rosmarinic Acid Potentiates Pentobarbital-Induced Sleep Behaviors and Non-Rapid Eye Movement (NREM) Sleep through the Activation of GABAA-ergic Systems [0.03%]
石松酸通过激活GABA能系统促进 pentobarbital诱导的睡眠行为和非快动眼(NREM)睡眠
Yeong Ok Kwon,Jin Tae Hong,Ki-Wan Oh
Yeong Ok Kwon
It has been known that RA, one of major constituents of Perilla frutescens which has been used as a traditional folk remedy for sedation in oriental countries, shows the anxiolytic-like and sedative effects. This study was performed to know...
Sensitization of 5-Fluorouracil-Resistant SNUC5 Colon Cancer Cells to Apoptosis by α-Mangostin [0.03%]
姜黄素联合白芒柄花素通过内质网应激和线粒体途径逆转结肠癌化疗耐药性
June Lee,Jong-Su Kang,Bu-Young Choi et al.
June Lee et al.
5-fluorouracil (5-FU) is a chemotherapeutic agent commonly used for treatment of solid tumors, including colorectal cancer. However, chemoresistance against 5-fluorouracil (5-FU) often limits its success for chemotherapy and, therefore, fin...
Pyrrole-Derivative of Chalcone, (E)-3-Phenyl-1-(2-Pyrrolyl)-2-Propenone, Inhibits Inflammatory Responses via Inhibition of Src, Syk, and TAK1 Kinase Activities [0.03%]
chalcone衍生物(E)-3-苯基-1-(2-吡咯基)-2-丙烯酮通过抑制Src、Syk和TAK1激酶活性抑制炎症反应
Sungjae Yang,Yong Kim,Deok Jeong et al.
Sungjae Yang et al.
(E)-3-Phenyl-1-(2-pyrrolyl)-2-propenone (PPP) is a pyrrole derivative of chalcone, in which the B-ring of chalcone linked to β-carbon is replaced by pyrrole group. While pyrrole has been studied for possible Src inhibition activity, chalco...
The Effect of (1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-Olide (LS-1) from Lobophyyum sp. on the Apoptosis Induction of SNU-C5 Human Colorectal Cancer Cells [0.03%]
尖叶龙血树来源化合物(1S,2S,3E,7E,11E)-3、7、11、15-半日花四烯-17、2-环氧化物(LS-1)对人结直肠癌SNU-C5细胞的促凋亡作用研究
Eun-Ji Kim,Jung Il Kang,Nguyen-Huu Tung et al.
Eun-Ji Kim et al.
(1S,2S,3E,7E,11E)-3,7,11,15-cembratetraen-17,2-olide (LS-1), a marine cembrenolide diterpene, has anticancer activity against colon cancer cells such as HT-29, SNU-C5/5-FU (fluorouracil-resistant SNU-C5) and SNU-C5. However, the action mech...
Isoflurane Preconditioning Induces Neuroprotection by Up-Regulation of TREK1 in a Rat Model of Spinal Cord Ischemic Injury [0.03%]
异氟醚预处理通过上调 TREK1 通道介导脊髓缺血再灌注损伤的神经保护作用
Kun Wang,Xiangang Kong
Kun Wang
This study aimed to explore the neuroprotection and mechanism of isoflurane on rats with spinal cord ischemic injury. Total 40 adult male Sprague-Dawley rats were divided into the four groups (n=10). Group A was sham-operation group; group ...
Identification of Neuroactive Constituents of the Ethyl Acetate Fraction from Cyperi Rhizoma Using Bioactivity-Guided Fractionation [0.03%]
基于活性的分离方法从虎杖中鉴定具有神经活性的成分
Yeomoon Sim,Jin Gyu Choi,Pil Sung Gu et al.
Yeomoon Sim et al.
Cyperi Rhizoma (CR), the rhizome of Cyperus rotundus L., exhibits neuroprotective effects in in vitro and in vivo models of neuronal diseases. Nevertheless, no study has aimed at finding the neuroactive constituent(s) of CR. In this study, ...
Aloe-Emodin Induces Chondrogenic Differentiation of ATDC5 Cells via MAP Kinases and BMP-2 Signaling Pathways [0.03%]
大黄素通过MAP激酶和BMP-2信号途径诱导ATDC5细胞软骨分化
Ming Yang,Liang Li,Seok-Mo Heo et al.
Ming Yang et al.
Endochondral bone formation is the process by which mesenchymal cells condense into chondrocytes, which are ultimately responsible for new bone formation. The processes of chondrogenic differentiation and hypertrophy are critical for bone f...
High Glucose Causes Human Cardiac Progenitor Cell Dysfunction by Promoting Mitochondrial Fission: Role of a GLUT1 Blocker [0.03%]
高葡萄糖通过促进线粒体分裂导致人类心脏祖细胞功能障碍及其机制研究：GLUT1抑制剂的作用
He Yun Choi,Ji Hye Park,Woong Bi Jang et al.
He Yun Choi et al.
Cardiovascular disease is the most common cause of death in diabetic patients. Hyperglycemia is the primary characteristic of diabetes and is associated with many complications. The role of hyperglycemia in the dysfunction of human cardiac ...