Restoration of Declined Immune Responses and Hyperlipidemia by Rubus occidenalis in Diet-Induced Obese Mice [0.03%]
Rubus occidentalis通过饮食诱导型肥胖小鼠恢复下降的免疫反应和高脂血症
Youngjoo Lee,Jiyeon Kim,Jinho An et al.
Youngjoo Lee et al.
Hyperlipidemia, which is closely associated with a fatty diet and aging, is commonly observed in the western and aged society. Therefore, a novel therapeutic approach for this disease is critical, and an immunological view has been suggeste...
Erratum to "Marine Sponges as a Drug Treasure" [Biomol.Ther. 24 (2016) 347-362] [0.03%]
关于“海洋海绵的药物价值”的勘误[生物分子治疗，第24卷(2016)，第347-362页]
Komal Anjum,Syed Qamar Abbas,SayedAsmat Ali Shah et al.
Komal Anjum et al.
The authors request to correct the title of Table 3 from 'Example of antiviral Compounds' to 'Example of Antifungal compounds.'
Published Erratum
Biomolecules & therapeutics. 2016 Sep 1;24(5):559. DOI:10.4062/biomolther.2016.559 2016
Evaluating Pharmacological Effects of Two Major Components of Shuangdan Oral Liquid: Role of Danshensu and Paeonol in Diabetic Nephropathy Rat [0.03%]
双丹口服液两个主要成分的药效学评价：丹参素和芍药醇防治糖尿病肾病的作用及机制研究
Ying Chen,Zhuying Liu,Fuxing Zhou et al.
Ying Chen et al.
Shuangdan oral liquid (SDO) containing radix Salviae miltiorrhizae (Chinese name Danshen) and cortex moutan (Chinese name Mudanpi) is a traditional Chinese medicine using for treating vascular diseases. Danshensu (DSS) is a main effective m...
Young-Ae Kim,Dong Gil Lee,Kyu Yang Yi et al.
Young-Ae Kim et al.
Urotensin II (UII) is a potent vasoactive peptide and mitogenic agent to induce proliferation of various cells including vascular smooth muscle cells (VSMCs). In this study, we examined the effects of a novel UII receptor (UT) antagonist, K...
Isoegomaketone Upregulates Heme Oxygenase-1 in RAW264.7 Cells via ROS/p38 MAPK/Nrf2 Pathway [0.03%]
异姜黄酮通过ROS/p38 MAPK/Nrf2信号通路诱导RAW264.7细胞HO-1的表达
Chang Hyun Jin,Yang Kang So,Sung Nim Han et al.
Chang Hyun Jin et al.
Isoegomaketone (IK) was isolated from Perilla frutescens, which has been widely used as a food in Asian cuisine, and evaluated for its biological activity. We have already confirmed that IK induced the HO-1 expression via Nrf2 activation in...
Involvement of NRF2 Signaling in Doxorubicin Resistance of Cancer Stem Cell-Enriched Colonospheres [0.03%]
NRF2信号通路参与多柔比星抗性结肠类器官肿瘤干细胞的研究
In-Geun Ryoo,Geon Kim,Bo-Hyun Choi et al.
In-Geun Ryoo et al.
Cancer stem cells (CSCs) are a subset of tumor cells, which are characterized by resistance against chemotherapy and environmental stress, and are known to cause tumor relapse after therapy. A number of molecular mechanisms underlie the che...
Proposal of Dual Inhibitor Targeting ATPase Domains of Topoisomerase II and Heat Shock Protein 90 [0.03%]
靶向拓扑异构酶II和热休克蛋白90的ATP酶结构域的双效抑制剂的设计与合成提案
Kyu-Yeon Jun,Youngjoo Kwon
Kyu-Yeon Jun
There is a conserved ATPase domain in topoisomerase II (topo II) and heat shock protein 90 (Hsp90) which belong to the GHKL (gyrase, Hsp90, histidine kinase, and MutL) family. The inhibitors that target each of topo II and Hsp90 are intensi...
Baicalein Inhibits the Migration and Invasion of B16F10 Mouse Melanoma Cells through Inactivation of the PI3K/Akt Signaling Pathway [0.03%]
黄芩素通过抑制PI3K/AKT信号通路从而抑制B16F10黑色素瘤细胞的迁移和侵袭能力
Eun-Ok Choi,Eun-Ju Cho,Jin-Woo Jeong et al.
Eun-Ok Choi et al.
Baicalein, a natural flavonoid obtained from the rhizome of Scutellaria baicalensis Georgi, has been reported to have anticancer activities in several human cancer cell lines. However, its antimetastatic effects and associated mechanisms in...
Expression Levels of GABA-A Receptor Subunit Alpha 3, Gabra3 and Lipoprotein Lipase, Lpl Are Associated with the Susceptibility to Acetaminophen-Induced Hepatotoxicity [0.03%]
GABA-A受体亚基α3，Gabra3以及脂蛋白脂肪酶，Lpl的表达水平与对乙酰氨基酚致肝毒性的易感性相关
Minjeong Kim,Jun-Won Yun,Kyeho Shin et al.
Minjeong Kim et al.
Drug-induced liver injury (DILI) is the serious and fatal drug-associated adverse effect, but its incidence is very low and individual variation in severity is substantial. Acetaminophen (APAP)-induced liver injury accounts for >50% of repo...
Chemical Constituents Identified from Fruit Body of Cordyceps bassiana and Their Anti-Inflammatory Activity [0.03%]
竹生虫草子实体的化学成分及其抗炎活性研究
Wonse Suh,Gyeongsug Nam,Woo Seok Yang et al.
Wonse Suh et al.
Cordyceps bassiana is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. This mushroom has recently demonstrated to have an ability to...