Biflorin Ameliorates Memory Impairments Induced by Cholinergic Blockade in Mice [0.03%]
双花内酯通过改善胆碱能功能障碍改善小鼠学习记忆损伤
Se Jin Jeon,Boseong Kim,Byeol Ryu et al.
Se Jin Jeon et al.
To examine the effect of biflorin, a component of Syzygium aromaticum, on memory deficit, we introduced a scopolamine-induced cognitive deficit mouse model. A single administration of biflorin increased latency time in the passive avoidance...
Tetrandrine Exerts a Radiosensitization Effect on Human Glioma through Inhibiting Proliferation by Attenuating ERK Phosphorylation [0.03%]
绞股蓝碱通过抑制ERK磷酸化减少细胞增殖从而增强放射治疗对人脑胶质瘤的作用
Ji-Wei Ma,Yong Zhang,Ji-Cheng Ye et al.
Ji-Wei Ma et al.
Tetrandrine (Tet), a bisbenzylisoquinoline alkaloid, has been reported to have a radiosensitization effect on tumors. However, its effects on human glioma and the specific molecular mechanisms of these effects remain unknown. In this study,...
Altered Translational Control of Fragile X Mental Retardation Protein on Myelin Proteins in Neuropsychiatric Disorders [0.03%]
神经精神疾病中髓鞘蛋白易脆性X染色体综合征智力低下蛋白翻译控制的改变
Se Jin Jeon,Jong Hoon Ryu,Geon Ho Bahn
Se Jin Jeon
Myelin is a specialized structure of the nervous system that both enhances electrical conductance and insulates neurons from external risk factors. In the central nervous system, polarized oligodendrocytes form myelin by wrapping processes ...
Protective Effects of Ecklonia stolonifera Extract on Ethanol-Induced Fatty Liver in Rats [0.03%]
石角鹿角藻提取物对酒精性肝损伤大鼠的保护作用研究
Chae-Young Bang,Jae-Hyuk Byun,Hye-Kyung Choi et al.
Chae-Young Bang et al.
Chronic alcohol consumption causes alcoholic liver disease, which is associated with the initiation of dysregulated lipid metabolism. Recent evidences suggest that dysregulated cholesterol metabolism plays an important role in the pathogene...
3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling [0.03%]
3-脱氧萨普氯仿促进人毛乳头细胞增殖和小鼠毛发生长的作用及机制研究
Young Eun Kim,Hyung Chul Choi,In-Chul Lee et al.
Young Eun Kim et al.
3-Deoxysappanchalcone (3-DSC) has been reported to possess anti-allergic, antiviral, anti-inflammatory and antioxidant activities. In the present study, we investigated the effects of 3-DSC on the proliferation of human hair follicle dermal...
Ulrike Lindequist
Ulrike Lindequist
Marine biosphere is the largest one of the earth and harbors an enormous number of different organisms. Living conditions differ fundamentally from those in terrestrial environment. The production of specific secondary metabolites is an imp...
Lonchocarpine Increases Nrf2/ARE-Mediated Antioxidant Enzyme Expression by Modulating AMPK and MAPK Signaling in Brain Astrocytes [0.03%]
Lonchocarpine通过调节AMPK和MAPK信号通路增加Nrf2 / ARE介导的抗氧化酶在脑星形胶质细胞中的表达
Yeon-Hui Jeong,Jin-Sun Park,Dong-Hyun Kim et al.
Yeon-Hui Jeong et al.
Lonchocarpine is a phenylpropanoid compound isolated from Abrus precatorius that has anti-bacterial, anti-inflammatory, antiproliferative, and antiepileptic activities. In the present study, we investigated the antioxidant effects of loncho...
Enforced Expression of CXCR5 Drives T Follicular Regulatory-Like Features in Foxp3+ T Cells [0.03%]
CXCR5强制表达驱动Foxp3⁺T细胞产生T follicular regulatory样表型
Young Uk Kim,Byung-Seok Kim,Hoyong Lim et al.
Young Uk Kim et al.
CXCR5+ T follicular helper (Tfh) cells are associated with aberrant autoantibody production in patients with antibody-mediated autoimmune diseases including lupus. Follicular regulatory T (Tfr) cells expressing CXCR5 and Bcl6 have been rece...
Cinnamaldehyde Derivatives Inhibit Coxsackievirus B3-Induced Viral Myocarditis [0.03%]
肉桂醛衍生物可抑制柯萨奇病毒B3致小鼠心肌炎作用
Xiao-Qiang Li,Xiao-Xiao Liu,Xue-Ying Wang et al.
Xiao-Qiang Li et al.
The chemical property of cinnamaldehyde is unstable in vivo, although early experiments have shown its obvious therapeutic effects on viral myocarditis (VMC). To overcome this problem, we used cinnamaldehyde as a leading compound to synthes...
Cheng Wen Yao,Kyoung Ah Kang,Mei Jing Piao et al.
Cheng Wen Yao et al.
We investigated the role of autophagy in SNUC5/5-FUR, 5-fluorouracil (5-FU) resistant SNUC5 colon cancer cells. SNUC5/5- FUR cells exhibited low level of autophagy, as determined by light microscopy, confocal microscopy, and flow cytometry ...