Auranofin Suppresses Plasminogen Activator Inhibitor-2 Expression through Annexin A5 Induction in Human Prostate Cancer Cells [0.03%]
金诺芬通过诱导 annexin a5 抑制人前列腺癌细胞中尿激酶型纤溶酶原激活剂受体的表达
Dong-Won Shin,Yeo-Jung Kwon,Dong-Jin Ye et al.
Dong-Won Shin et al.
Auranofin has been developed as antirheumatic drugs, which is currently under clinical development for the treatment of chronic lymphocytic leukemia. Previous report showed that auranofin induced apoptosis by enhancement of annexin A5 expre...
Characterization of a Biflaviolin Synthase CYP158A3 from Streptomyces avermitilis and Its Role in the Biosynthesis of Secondary Metabolites [0.03%]
链霉菌阿维霉素素中的双黄素合成酶CYP158A3的表征及其在次级代谢产物生物合成中的作用
Young-Ran Lim,Songhee Han,Joo-Hwan Kim et al.
Young-Ran Lim et al.
Streptomyces avermitilis produces clinically useful drugs such as avermectins and oligomycins. Its genome contains approximately 33 cytochrome P450 genes and they seem to play important roles in the biosynthesis of many secondary metabolite...
Induction of Integrin Signaling by Steroid Sulfatase in Human Cervical Cancer Cells [0.03%]
人宫颈癌细胞中皮质醇硫酸酯还原酶诱导整合素信号转导路径
Dong-Jin Ye,Yeo-Jung Kwon,Sangyun Shin et al.
Dong-Jin Ye et al.
Steroid sulfatase (STS) is an enzyme responsible for the hydrolysis of aryl and alkyl sulfates. STS plays a pivotal role in the regulation of estrogens and androgens that promote the growth of hormone-dependent tumors, such as those of brea...
Platelet Shape Changes and Cytoskeleton Dynamics as Novel Therapeutic Targets for Anti-Thrombotic Drugs [0.03%]
血小板形态改变和细胞骨架动力学作为抗血栓药物的新治疗靶点
Eun-Kyung Shin,Hanseul Park,Ji-Yoon Noh et al.
Eun-Kyung Shin et al.
Platelets play an essential role in hemostasis through aggregation and adhesion to vascular injury sites but their unnecessary activation can often lead to thrombotic diseases. Upon exposure to physical or biochemical stimuli, remarkable pl...
Synthetic Cannabinoid-Induced Immunosuppression Augments Cerebellar Dysfunction in Tetanus-Toxin Treated Mice [0.03%]
合成大麻素诱导的免疫抑制加重了破伤风毒素处理的小鼠小脑功能障碍
Jaesuk Yun,Sun Mi Gu,Tac-Hyung Lee et al.
Jaesuk Yun et al.
Synthetic cannabinoids are one of most abused new psychoactive substances. The recreational use of abused drug has aroused serious concerns about the consequences of these drugs on infection. However, the effects of synthetic cannabinoid on...
Kahweol from Coffee Induces Apoptosis by Upregulating Activating Transcription Factor 3 in Human Colorectal Cancer Cells [0.03%]
咖啡中的 Kahweol通过上调活化转录因子3诱导人类结直肠癌细胞凋亡
Gwang Hun Park,Hun Min Song,Jin Boo Jeong
Gwang Hun Park
Kahweol as a coffee-specific diterpene has been reported to induce apoptosis in human cancer cells. Although some molecular targets for kahweol-mediated apoptosis have been elucidated, the further mechanism for apoptotic effect of kahweol i...
Protective Role of Fucoidan in Cerebral Ischemia-Reperfusion Injury through Inhibition of MAPK Signaling Pathway [0.03%]
通过抑制MAPK信号途径褐藻糖胶对脑缺血再灌注损伤的保护作用
Nan Che,Yijie Ma,Yinhu Xin
Nan Che
Fucoidan has been reported to exhibit various beneficial activities ranging from to antivirus and anticancer properties. However, little information is available about the effects of fucoidan on cerebral ischemia-reperfusion injury (IRI). O...
Neuroprotection of Dexmedetomidine against Cerebral Ischemia-Reperfusion Injury in Rats: Involved in Inhibition of NF-κB and Inflammation Response [0.03%]
度米芬托咪定对大鼠脑缺血再灌注损伤的神经保护作用及NF-κB和炎症反应参与机制研究
Lijun Wang,Haiyan Liu,Ligong Zhang et al.
Lijun Wang et al.
Dexmedetomidine is an α2-adrenergic receptor agonist that exhibits a protective effect on ischemia-reperfusion injury of the heart, kidney, and other organs. In the present study, we examined the neuroprotective action and potential mechan...
Galangin Activates the ERK/AKT-Driven Nrf2 Signaling Pathway to Increase the Level of Reduced Glutathione in Human Keratinocytes [0.03%]
染料木素通过激活ERK/AKT驱动的Nrf2信号通路增加人体角质细胞中谷胱甘肽含量
Susara Ruwan Kumara Madduma Hewage,Mei Jing Piao,Kyoung Ah Kang et al.
Susara Ruwan Kumara Madduma Hewage et al.
Previously, we demonstrated that galangin (3,5,7-trihydroxyflavone) protects human keratinocytes against ultraviolet B (UVB)-induced oxidative damage. In this study, we investigated the effect of galangin on induction of antioxidant enzymes...
Ginsenoside Rb1 Inhibits Doxorubicin-Triggered H9C2 Cell Apoptosis via Aryl Hydrocarbon Receptor [0.03%]
绞股蓝皂苷Rb1通过芳烃受体抑制多柔比星诱导的H9C2细胞凋亡
Yaxin Zhang,Yuguang Wang,Zengchun Ma et al.
Yaxin Zhang et al.
Doxorubicin (DOX) is a highly effective chemotherapeutic agent; however, the dose-dependent cardiotoxicity associated with DOX significantly limits its clinical application. In the present study, we investigated whether Rb1 could prevent DO...