Bioinformatic Analysis to Identify Biomarker Candidates of Complex Karyotype Soft Tissue Sarcomas with CDK4-Amplification [0.03%]
生物信息分析鉴定复杂染色体变异型CDK4扩增型软组织肉瘤生物标志物候选分子
Eun-Young Lee,Hyun Sang Cho,June Hyuk Kim et al.
Eun-Young Lee et al.
Soft tissue sarcomas (STSs), a diverse group of mesenchymal malignancies, are characterized primarily by copy-number alterations rather than a high tumor mutation burden. In this study, we sought to identify expression-based biomarkers in c...
Aβ₁₋₄₀ Enhances Platelet Sensitivity to Thrombin via NADPH Oxidase-ROS Signaling and Integrin αIIbβ₃ Engagement [0.03%]
AB₁₋₄₀通过NADPH氧化酶-ROS信号和整合素αIIbβ₃参与增强血小板对凝血酶的敏感性
Been Kim,Bo Kyung Lee,Jung-Ae Kim et al.
Been Kim et al.
Alzheimer's disease (AD) is increasingly recognized as a disorder with significant vascular involvement, with microvascular damage and thromboinflammation often preceding classical amyloid pathology by several years. Elevated levels of prot...
Role of Adenosine Receptors in Sleep Deprivation-Induced Depression-Like Behaviors [0.03%]
腺苷受体在睡眠剥夺诱导的类似抑郁行为中的作用
Nan Ju Lee,Yi-Sook Jung
Nan Ju Lee
Sleep deprivation (SD) disrupts homeostatic regulation and increases vulnerability to stress and mood disorders. This study investigated the duration-dependent effects of SD and elucidated the distinct roles of adenosine A1 receptors (A1R) ...
Clemastine Restores Myelination Protein Expression in S16 Schwann Cells by Enhancing AMPK Activation and Reducing H2O2-Induced Oxidative Stress [0.03%]
氯马斯汀通过增强AMPK活化和减少H2O2诱导的氧化应激恢复S16雪旺细胞髓鞘蛋白质表达
Chawon Yun,So Young Lee,Jun Hong Won et al.
Chawon Yun et al.
Peripheral nerve injury and oxidative stress can severely impair Schwann cell function by disrupting the expression of key myelin proteins, promoting intracellular lipid accumulation, and damaging mitochondrial integrity. These pathological...
Phage Display Technology: Design, Library Construction, and Panning Strategies for Antibody Development [0.03%]
噬菌体展示技术用于抗体开发的设计、文库构建及筛选策略
Hobin Yang
Hobin Yang
Phage display technology serves as a powerful in vitro platform for discovering antigen-specific antibodies, enabling the rapid identification and engineering of monoclonal antibodies for therapeutic applications. This review discusses key ...
Quinoxaline Derivatives in Cancer Therapy: Insights into Mechanisms of Action and Therapeutic Applications [0.03%]
喹唑啉衍生物在癌症治疗中的作用机制及治疗应用研究
Jinan Alhuwayshil,Nouf Alnajim,Sarah Bin Dulaym et al.
Jinan Alhuwayshil et al.
Cancer continues to be a leading cause of morbidity and mortality globally, which necessitates the development of more effective and less toxic therapies. Quinoxaline derivatives, a class of heterocyclic compounds with versatile chemical st...
Molecular Mechanisms Underlying the Anti-Cancer Effects of Tangeretin, a Phytochemical from Citrus Extracts [0.03%]
柑橘提取物化合物橙皮素的抗肿瘤作用机制研究
Seung-Hyeon Ahn,Kyung-Chul Choi
Seung-Hyeon Ahn
Cancer is one of the diseases with high incidence and mortality rates. As a result, many studies have led to the development of therapeutic agents such as immune checkpoint inhibitors. However, the research on cancer treatment is still esse...
Muhammad Kamal Hossain,Hyung-Ryong Kim
Muhammad Kamal Hossain
The decline of proteostasis is a central hallmark of aging, the earliest manifestations of which have remained difficult to capture in human tissues with conventional model systems. The skin is a continuously renewing and environmentally ex...
Hypoxia Preserves Chromatin Integrity and Delays Cellular Senescence through Epigenetic Regulation [0.03%]
缺氧通过表观遗传调控维持染色质稳定并延缓细胞衰老
Chansang Park,Hyunsung Park
Chansang Park
Hypoxia is a physiologically relevant microenvironment in both normal and diseased tissues and has emerged as a potent modulator of cellular senescence and organismal longevity. This review synthesizes evidence that hypoxia delays senescenc...
Immunosenescence in Human Disease: Mechanistic Insights and Therapeutic Opportunities [0.03%]
人类疾病中的免疫衰老：机制见解和治疗机会
Young-In Kim,Seo-Hee Oh,Tae Kyoung Lim et al.
Young-In Kim et al.
Immunosenescence, an age-associated decline in immune function, is increasingly recognized as a central determinant of health and disease in older adults. Characterized by thymic involution, loss of naïve T cells, contraction of T cell rec...