Ferroptosis-Driven Senescence Loop as a Central Amplifier of Osteoarthritis Progression [0.03%]
铁死亡驱动的衰老循环是骨关节炎进展的核心放大器
Rajib Hossain,Hyun Jae Lee,Md Solayman Hossain et al.
Rajib Hossain et al.
Osteoarthritis (OA) is a prevalent, chronic joint disorder characterized by cartilage degradation, synovial inflammation, and extracellular matrix (ECM) remodeling, yet disease-modifying therapies remain elusive. Emerging evidence implicate...
Jinseon Park,Jaebeom Cho
Jinseon Park
The emergence of therapy resistance remains a formidable barrier to successful clinical outcomes in oncology, necessitating a deeper understanding of the tumor microenvironment (TME) as a dynamic ecosystem. Adipocytes, once viewed as passiv...
Developmental Exposure to Endocrine Disruptors and Persistent Pollutants Heightens Addiction Risk via Toxicological Mechanisms [0.03%]
发育过程中接触内分泌干扰物和持久性污染物通过毒理学机制增加成瘾风险
Se Jin Jeon,Dae Hyun Kim,Chan Young Shin
Se Jin Jeon
Endocrine-disrupting chemicals (EDCs) and persistent organic pollutants (POPs) cross the placenta and accumulate during gestation and early postnatal life, periods of heightened hormonal and neurodevelopmental plasticity. Exposure to contam...
Adenosine A1 and A2A Receptors in Sleep Disorders: Mechanisms and Therapeutic Implications [0.03%]
腺苷A1和A2A受体在睡眠障碍中的机制及治疗意义
Hye Jin Jee,Cherin Youn,Haeun Lee et al.
Hye Jin Jee et al.
Sleep-wake regulation is controlled by circadian and homeostatic processes, with adenosine acting as a key molecular mediator of homeostatic sleep pressure. Extracellular adenosine accumulates during wakefulness as a result of neuronal ener...
Exploring LEPR-Linked Metabolic Diversity through Gut Microbiome-Metabolome Network Analysis in Non-Obese Adults [0.03%]
通过肠道微生物组-代谢组网络分析在非肥胖成年人群中探索LEPR相关的代谢多样性
Kyeong-Seog Kim,Joo-Youn Cho,Ye Chan Park et al.
Kyeong-Seog Kim et al.
Genetic variation in the leptin receptor (LEPR) gene has been implicated in metabolic regulation, while the gut microbiome and circulating metabolites are increasingly recognized as mediators of host metabolic phenotype. However, the system...
Celafolin A-1 Ameliorates Subretinal Fibrosis via Inhibition of Crystallin Alpha B in a Laser-Induced Choroidal Neovascularization Mouse Model [0.03%]
塞来福林A-1通过抑制激光诱导的脉络膜新生血管小鼠模型中的αB晶体蛋白改善视网膜下纤维化
Eunhye Yu,Sun Mi Gu,Haechan Kim et al.
Eunhye Yu et al.
Age-related macular degeneration (AMD) is a leading cause of blindness in people over 65 years old. Anti-vascular endothelial growth factor (VEGF) therapy is the first-line treatment for neovascular AMD (nAMD); however, fibrosis remains an ...
Crebanine Protects HUVECs from LPS-Induced Inflammation and Oxidative Stress by Suppressing NF-κB Pathway [0.03%]
克雷班宁通过抑制NF-κB途径保护内皮细胞免受脂多糖诱导的炎症和氧化应激损伤
Hao Chen,Liyuan Luo,Yunzhu Guo et al.
Hao Chen et al.
Endothelial dysfunction induced by inflammation and oxidative stress represents a critical pathological mechanism in cardiovascular and cerebrovascular diseases, including sepsis and atherosclerosis. Although crebanine has been reported to ...
Pluviatolide Attenuates Type I Hypersensitivity through Regulation of Mast Cell Activation [0.03%]
雨曲素通过调节肥大细胞活化抑制I型超敏反应
Seon Young Kim,Jeong Won Park,Juhyun Shin et al.
Seon Young Kim et al.
This study examined the inhibitory effects of pluviatolide, a lignan derived from Podophyllum hexandrum, on mast cell activation and IgE-mediated type I hypersensitivity, focusing on FcεRI-dependent and calcium-mediated pathways. Using bon...
γ-Oryzanol Ameliorates Endothelial Replicative Senescence via Downregulation of SGLT2 Expression to Attenuate NADPH-Driven Oxidative Stress [0.03%]
γ-稻谷醇通过下调SGLT2表达来缓解内皮细胞复制性衰老以减轻NADPH驱动的氧化应激
Saugat Shiwakoti,Kushal Sharma,Dal-Seong Gong et al.
Saugat Shiwakoti et al.
Replicative senescence in endothelial cells is characterized by an irreversible cell cycle arrest and impaired endothelial function, contributing to vascular aging and cardiovascular disease. Natural compounds are being actively studied for...
Exploratory Proteomic Profiling Reveals Potential Mediators of 5-FU Response under p53 Deficiency in Colon Cancer Cells [0.03%]
探索性蛋白质组学分析发现结肠癌细胞中p53缺陷状态下5-氟尿嘧啶响应的潜在介导因素
Seonyong Lee,Jiwon Lee,Ga Seul Lee et al.
Seonyong Lee et al.
Mutations in p53 have been implicated in poor prognosis and reduced sensitivity to 5-fluorouracil (5-FU) treatment in colon cancer. While p53-dependent mechanisms have been widely studies, less is known about how p53 deficiency reshapes cel...