Inhibition of Melanosome Transport by Inducing Exon Skipping in Melanophilin [0.03%]
诱导Melanophilin外显子跳过抑制黑素体运输
Jin Young Kim,Seon-Young Han,Kiho Sung et al.
Jin Young Kim et al.
Exon skipping is an efficient technique to inhibit specific gene expression induced by a short-sequence peptide nucleic acid (PNA). To date, there has been no study on the effects of PNA on skin pigmentation. In melanocytes, the tripartite ...
Mihwa Hwang,Dong Wha Jun,Bo Ram Song et al.
Mihwa Hwang et al.
Ataxia-telangiectasia mutated (ATM), a master kinase of the DNA damage response (DDR), phosphorylates a multitude of substrates to activate signaling pathways after DNA double-strand breaks (DSBs). ATM inhibitors have been evaluated as anti...
Caspase Cleavage of Receptor Tyrosine Kinases in the Dependence Receptor Family [0.03%]
依赖受体家族中的丝裂原活化蛋白激酶的半胱天冬酶切割作用
Gyu Hwan Park,Yoo Kyung Kang,Seung-Mann Paek et al.
Gyu Hwan Park et al.
Dependence receptors are a group of receptor proteins with shared characteristics of transducing two different signals within cells. They can transduce a positive signal of survival and differentiation in the presence of ligands. On the oth...
5-Hydroxytryptophan Reduces Levodopa-Induced Dyskinesia via Regulating AKT/mTOR/S6K and CREB/ΔFosB Signals in a Mouse Model of Parkinson's Disease [0.03%]
五羟色胺代谢中间产物5-HTP通过调节Akt/mTOR/S6K和CREB/ΔFosB信号减少帕金森病模型小鼠左旋多巴诱发的异动症
Yujin Choi,Eugene Huh,Seungmin Lee et al.
Yujin Choi et al.
Long-term administration of levodopa (L-DOPA) to patients with Parkinson's disease (PD) commonly results in involuntary dyskinetic movements, as is known for L-DOPA-induced dyskinesia (LID). 5-Hydroxytryptophan (5-HTP) has recently been sho...
Differences in Neurotransmitters Level as Biomarker on Sleep Effects in Dementia Patients with Insomnia after Essential Oils Treatment [0.03%]
失眠症患者经精油治疗后痴呆患者的生物标志物神经递质水平的差异及对睡眠的影响
Kyung-Bok Lee,Sana Latif,Young-Sook Kang
Kyung-Bok Lee
This study aimed to examine the effects of several essential oils on insomnia in dementia patients following transdermal treatment (aromatherapy). The mean change rates (%) of sleep biomarkers were compared between the single essential and ...
Yeonjoon Kim
Yeonjoon Kim
The era of innovative RNA therapies using antisense oligonucleotides (ASOs), siRNAs, and mRNAs is beginning. Since the emergence of the concept of ASOs in 1978, it took more than 20 years before they were developed into drugs for commercial...
4-F-PCP, a Novel PCP Analog Ameliorates the Depressive-Like Behavior of Chronic Social Defeat Stress Mice via NMDA Receptor Antagonism [0.03%]
新型氯胺酮类似物4-F-PCP通过谷氨酸N-甲基-D-天冬氨酸受体拮抗作用缓解慢性社交挫败应激小鼠的抑郁样行为
Darlene Mae D Ortiz,Mikyung Kim,Hyun Jun Lee et al.
Darlene Mae D Ortiz et al.
Major depressive disorder is a leading cause of disability in more than 280 million people worldwide. Monoamine-based antidepressants are currently used to treat depression, but delays in treatment effects and lack of responses are major re...
Dogyeoung Kim,Sumin Kim,Yongdae Kwon et al.
Dogyeoung Kim et al.
Antibiotic resistance has emerged as a global threat to modern healthcare systems and has nullified many commonly used antibiotics. β-Lactam antibiotics are among the most successful and occupy approximately two-thirds of the prescription ...
Megakaryocyte-Derived IL-8 Acts as a Paracrine Factor for Prostate Cancer Aggressiveness through CXCR2 Activation and Antagonistic AR Downregulation [0.03%]
巨核细胞衍生的IL-8通过CXCR2激活和抗雄激素作用下调充当前列腺癌侵袭性的旁分泌因子
Sadan Dahal,Prakash Chaudhary,Yi-Sook Jung et al.
Sadan Dahal et al.
Prostate cancer is the fifth leading cause of cancer-related mortality in men, primarily because of treatment resistance, recurrence, and metastasis. In the present study, we investigated the role of paracrine interleukin-8 (IL-8) in the an...
8-Methoxypsoralen Induces Apoptosis by Upregulating p53 and Inhibits Metastasis by Downregulating MMP-2 and MMP-9 in Human Gastric Cancer Cells [0.03%]
8-甲氧补骨脂素通过上调p53诱导凋亡并通过下调MMP-2和MMP-9抑制人胃癌细胞转移
Eun Kyoung Choi,Hae Dong Kim,Eun Jung Park et al.
Eun Kyoung Choi et al.
Furanocoumarin 8-methoxypsoralen (8-MOP) is the parent compound that naturally occurs in traditional medicinal plants used historically. 8-MOP has been employed as a photochemotherapeutic component of Psoralen + Ultraviolet A (PUVA) therapy...