3-Deoxysappanchalcone Inhibits Cell Growth of Gefitinib-Resistant Lung Cancer Cells by Simultaneous Targeting of EGFR and MET Kinases [0.03%]
3-脱氧萨普安宁通过同时靶向EGFR和MET激酶抑制吉非替尼耐药肺癌细胞的生长
Jin-Young Lee,Seung-On Lee,Ah-Won Kwak et al.
Jin-Young Lee et al.
The mechanistic functions of 3-deoxysappanchalcone (3-DSC), a chalcone compound known to have many pharmacological effects on lung cancer, have not yet been elucidated. In this study, we identified the comprehensive anti-cancer mechanism of...
Synergistic Renoprotective Effect of Melatonin and Zileuton by Inhibition of Ferroptosis via the AKT/mTOR/NRF2 Signaling in Kidney Injury and Fibrosis [0.03%]
通过抑制铁死亡途径中的AKT/mTOR/NRF2信号通路，褪黑素和齐勒út联合的协同肾脏保护作用促进肾损伤和纤维化
Kyung Hee Jung,Sang Eun Kim,Han Gyeol Go et al.
Kyung Hee Jung et al.
According to recent evidence, ferroptosis is a major cell death mechanism in the pathogenesis of kidney injury and fibrosis. Despite the renoprotective effects of classical ferroptosis inhibitors, therapeutic approaches targeting kidney fer...
Liver Kinase B1 Mediates Its Anti-Tumor Function by Binding to the N-Terminus of Malic Enzyme 3 [0.03%]
肝激酶B1通过与苹果酸酶3的N端结合发挥其抑癌功能
Seung Bae Rho,Hyun Jung Byun,Boh-Ram Kim et al.
Seung Bae Rho et al.
Liver kinase B1 (LKB1) is a crucial tumor suppressor involved in various cellular processes, including embryonic development, tumor initiation and progression, cell adhesion, apoptosis, and metabolism. However, the precise mechanisms underl...
Exosomes: Nomenclature, Isolation, and Biological Roles in Liver Diseases [0.03%]
外泌体：命名、分离和在肝病中的生物学作用
Seol Hee Park,Eun Kyeong Lee,Joowon Yim et al.
Seol Hee Park et al.
The biogenesis and biological roles of extracellular vesicles (EVs) in the progression of liver diseases have attracted considerable attention in recent years. EVs are membrane-bound nanosized vesicles found in different types of body fluid...
Hyun-Jeong Ko,Yeon-Jeong Kim
Hyun-Jeong Ko
The COVID-19 pandemic has increased demand for safe and effective vaccines. Research to develop vaccines against diseases including Middle East respiratory syndrome, Ebolavirus, human immunodeficiency virus, and various cancers would also c...
A Bivalent Inactivated Vaccine Prevents Enterovirus 71 and Coxsackievirus A16 Infections in the Mongolian Gerbil [0.03%]
一种二价灭活疫苗可预防肠病毒71型和柯萨奇病毒A16型病毒感染疣鼠
Eun-Je Yi,Young-In Kim,Seung-Yeon Kim et al.
Eun-Je Yi et al.
Hand-foot-and-mouth disease (HFMD) is a viral infectious disease that occurs in children under 5 years of age. Its main causes are coxsackievirus (CV) and enterovirus (EV). Since there are no efficient therapeutics for HFMD, vaccines are ef...
Anti-Fibrotic Effects of DL-Glyceraldehyde in Hepatic Stellate Cells via Activation of ERK-JNK-Caspase-3 Signaling Axis [0.03%]
DL-甘油醛通过激活ERK-JNK-caspase-3信号轴发挥抗肝纤维化作用
Md Samsuzzaman,Sun Yeou Kim
Md Samsuzzaman
During liver injury, hepatic stellate cells can differentiate into myofibroblast-like structures, which are more susceptible to proliferation, migration, and extracellular matrix generation, leading to liver fibrosis. Anaerobic glycolysis i...
Meclofenamate Suppresses MUC5AC Mucin Gene Expression by Regulating the NF-kB Signaling Pathway in Human Pulmonary Mucoepidermoid NCI-H292 Cells [0.03%]
美洛昔康通过调节NF-κB信号途径抑制人肺黏膜上皮样细胞NCI-H292中MUC5AC基因的表达
Jiho Ryu,Kyung-Il Kim,Rajib Hossain et al.
Jiho Ryu et al.
The current study aimed to reveal the potential effect of meclofenamate, a nonsteroidal anti-inflammatory drug, on the gene expression of airway MUC5AC mucin. Human pulmonary mucoepidermoid NCI-H292 cells were pretreated with meclofenamate ...
Chromatographic Determination of the Absolute Configuration in Sanjoinine A That Increases Nitric Oxide Production [0.03%]
色谱测定异株苦玄参与促进一氧化氮产生的绝对构型_sanjoinine A
Soohyun Um,Hyeongju Jeong,Joon Soo An et al.
Soohyun Um et al.
A chiral derivatization strategy with phenylglycine methyl ester (PGME) was employed to develop a straightforward method to determine the absolute configurations of N,N-dimethyl amino acids. The PGME derivatives were analyzed using liquid c...
Effect of FTY-720 on Pulmonary Fibrosis in Mice via the TGF-β1 Signaling Pathway and Autophagy [0.03%]
FTY-720通过TGF-β1信号通路和自噬对小鼠肺纤维化的干预作用研究
Yuying Jin,Weidong Liu,Ge Gao et al.
Yuying Jin et al.
We investigated whether FTY-720 might have an effect on bleomycin-induced pulmonary fibrosis through inhibiting TGF-β1 pathway, and up-regulating autophagy. The pulmonary fibrosis was induced by bleomycin. FTY-720 (1 mg/kg) drug was intrap...