Phytoceramide Alleviates the Carrageenan/Kaolin-Induced Arthritic Symptoms by Modulation of Inflammation [0.03%]
植物神经酰胺通过调节炎症缓解角叉菜胶/高岭土诱导的关节炎症状
Bongjun Sur,Mijin Kim,Thea Villa et al.
Bongjun Sur et al.
Phytoceramide (Pcer) is found mainly in plants and yeast. It can be neuroprotective and immunostimulatory on various cell types. In this study, the therapeutic effect of Pcer was explored using the carrageenan/kaolin (C/K)-induced arthritis...
Annamneedi Venkata Prakash,Il-Ho Park,Jun Woo Park et al.
Annamneedi Venkata Prakash et al.
Innate immunity is a first line defence system in the body which is for sensing signals of danger such as pathogenic microbes or host-derived signals of cellular stress. Pattern recognition receptors (PRR's), which present in the cell memeb...
Niclosamide Inhibits Aortic Valve Interstitial Cell Calcification by Interfering with the GSK-3β/β-Catenin Signaling Pathway [0.03%]
尼克利斯胺通过干扰GSK-3β/β-连环素信号通路抑制主动脉瓣间质细胞钙化
Radhika Adhikari,Saugat Shiwakoti,Eunmin Kim et al.
Radhika Adhikari et al.
The most common heart valve disorder is calcific aortic valve stenosis (CAVS), which is characterized by a narrowing of the aortic valve. Treatment with the drug molecule, in addition to surgical and transcatheter valve replacement, is the ...
LKB1/STK11 Tumor Suppressor Reduces Angiogenesis by Directly Interacting with VEGFR2 in Tumorigenesis [0.03%]
LKB1/STK11抑癌基因通过直接与VEGFR2结合在肿瘤发生过程中抑制血管生成
Seung Bae Rho,Hyun Jung Byun,Boh-Ram Kim et al.
Seung Bae Rho et al.
Cervical tumors represent a prevalent form of cancer affecting women worldwide; current treatment options involve surgery, radiotherapy, and chemotherapy. Angiogenesis, the process of new blood vessel formation, is a crucial factor in cervi...
Jong Hun Kim,Min Sik Choi
Jong Hun Kim
Nitric oxide (NO) is a signaling molecule that plays a crucial role in numerous cellular physiological processes. In the skin, NO is produced by keratinocytes, fibroblasts, endothelial cells, and immune cells and is involved in skin functio...
6-Shogaol, an Active Ingredient of Ginger, Improves Intestinal and Brain Abnormalities in Proteus Mirabilis-Induced Parkinson's Disease Mouse Model [0.03%]
6-姜酚通过改善肠道菌群屏障功能及减少α-突触核蛋白沉积缓解变形杆菌诱发的小鼠帕金森病模型的症状研究
Eugene Huh,Jin Gyu Choi,Yujin Choi et al.
Eugene Huh et al.
Parkinson's disease (PD) which has various pathological mechanisms, recently, it is attracting attention to the mechanism via microbiome-gut-brain axis. 6-Shogaol, a representative compound of ginger, have been known for improving PD phenot...
Alisol B 23-Acetate Ameliorates Ovalbumin-Induced Allergic Asthma during Sensitization and Challenge Periods [0.03%]
郁金素B-23乙酸酯通过调控Th1/Th2失衡改善卵清蛋白致敏的小鼠哮喘模型病情
Ki-Hyuk Nam,Dong-Soon Im
Ki-Hyuk Nam
Rhizome of Alisma orientale has been used as a traditional medicine for treating kidney diseases in East Asian countries. Its inhibitory effects on hypersensitivity responses have been reported for methanol extracts, with alisol B 23-acetat...
Searching for Novel Candidate Small Molecules for Ameliorating Idiopathic Pulmonary Fibrosis: a Narrative Review [0.03%]
寻找改善特发性肺纤维化的新候选小分子：叙述性综述
Kyung-Il Kim,Rajib Hossain,Xin Li et al.
Kyung-Il Kim et al.
Idiopathic pulmonary fibrosis (IPF) can be defined as a progressive chronic pulmonary disease showing scarring in the lung parenchyma, thereby resulting in increase in mortality and decrease in the quality of life. The pathophysiologic mech...
Regulation of the Gene Expression of Airway MUC5AC Mucin through NF-κB Signaling Pathway by Artesunate, an Antimalarial Agent [0.03%]
抗疟药青蒿素通过NF-κB信号途径调控气道MUC5AC黏蛋白基因表达
Kyung-Il Kim,Rajib Hossain,Jiho Ryu et al.
Kyung-Il Kim et al.
In this study, artesunate, an antimalarial agent, was investigated for its potential effect on the gene expression of airway MUC5AC mucin. The human pulmonary epithelial NCI-H292 cells were pretreated with artesunate for 30 min and then sti...
Cremastranone-Derived Homoisoflavanes Suppress the Growth of Breast Cancer Cells via Cell Cycle Arrest and Caspase-Independent Cell Death [0.03%]
克雷马斯特拉none衍生的同源异黄烷通过细胞周期阻滞和半胱天冬酶非依赖性细胞死亡抑制乳腺癌细胞增殖
Yeram Choi,Sangkyu Park,Seul Lee et al.
Yeram Choi et al.
Breast cancer is the most common cancer and a frequent cause of cancer-related deaths among women wordlwide. As therapeutic strategies for breast cancer have limitations, novel chemotherapeutic reagents and treatment strategies are needed. ...