Ai-Young Lee
Ai-Young Lee
Adverse drug reactions (ADRs) are an inherent aspect of drug use. While approximately 80% of ADRs are predictable, immune system-mediated ADRs, often unpredictable, are a noteworthy subset. Skin-related ADRs, in particular, are frequently u...
Bortezomib Is Toxic but Induces Neurogenesis and Inhibits TUBB3 Degradation in Rat Neural Stem Cells [0.03%]
硼替佐米具有神经毒性但能诱导新生神经元的生成并抑制神经干细胞中TUBB3蛋白降解
Seung Yeon Sohn,Thin Thin San,Junhyung Kim et al.
Seung Yeon Sohn et al.
Bortezomib (BTZ) is a proteasome inhibitor used to treat multiple myeloma (MM). However, the induction of peripheral neuropathy is one of the major concerns in using BTZ to treat MM. In the current study, we have explored the effects of BTZ...
Domperidone Exerts Antitumor Activity in Triple-Negative Breast Cancer Cells by Modulating Reactive Oxygen Species and JAK/STAT3 Signaling [0.03%]
多潘立酮通过调节活性氧和JAK/STAT3信号在三阴性乳腺癌细胞中发挥抗肿瘤作用
Rajina Shakya,Mi Ran Byun,Sang Hoon Joo et al.
Rajina Shakya et al.
The lack of molecular targets hampers the treatment of triple-negative breast cancer (TNBC). In this study, we determined the cytotoxicity of domperidone, a dopamine D2 receptor (DRD2) antagonist in human TNBC BT-549 and CAL-51 cells. Dompe...
Licochalcone D Inhibits Skin Epidermal Cells Transformation through the Regulation of AKT Signaling Pathways [0.03%]
抑癌化合物/licochalcone D通过调节AKT信号途径抑制皮肤表皮细胞转化的作用及机制研究
Sun-Young Hwang,Kwanhwan Wi,Goo Yoon et al.
Sun-Young Hwang et al.
Cell transformation induced by epidermal growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) is a critical event in cancer initiation and progression, and understanding the underlying mechanisms is essential for the developme...
Licochalcone H Targets EGFR and AKT to Suppress the Growth of Oxaliplatin -Sensitive and -Resistant Colorectal Cancer Cells [0.03%]
白花青素H通过靶向EGFR和AKT抑制奥沙利铂敏感性和抗性结直肠癌细胞的生长
Seung-On Lee,Mee-Hyun Lee,Ah-Won Kwak et al.
Seung-On Lee et al.
Treatment of colorectal cancer (CRC) has always been challenged by the development of resistance. We investigated the antiproliferative activity of licochalcone H (LCH), a regioisomer of licochalcone C derived from the root of Glycyrrhiza i...
Sex Differences in the Preventive Effect of Cardiovascular and Metabolic Therapeutics on Dementia [0.03%]
心血管和代谢类药物对痴呆预防作用的性别差异分析
Sun Ah Choi,Hye Jin Jee,Katrina Joy Bormate et al.
Sun Ah Choi et al.
Dementia is a clinical syndrome characterized by progressive impairment of cognitive and functional abilities. As currently applied treatments for dementia can only delay the progression of dementia and cannot fundamentally cure it, much at...
Aquaporin-3 Downregulation in Vitiligo Keratinocytes Increases Oxidative Stress of Melanocytes [0.03%]
色素细胞氧化应激增加与白癜风角朊细胞aquaporin-3下调有关
Nan-Hyung Kim,Ha Jung Kim,Ai-Young Lee
Nan-Hyung Kim
Oxidative stress-induced melanocyte apoptosis is linked to the immune system and plays a critical role in the pathogenesis of vitiligo. Aquaporin-3 (AQP3), which is downregulated in vitiligo keratinocytes, regulates intracellular H2O2 accum...
Effect of Prunetin on Streptozotocin-Induced Diabetic Nephropathy in Rats - a Biochemical and Molecular Approach [0.03%]
榅桲乙酸酯对链脲佐菌素致糖尿病大鼠肾损害的生化及分子机制研究
Jose Vinoth Raja Antony Samy,Nirubama Kumar,Sengottuvelu Singaravel et al.
Jose Vinoth Raja Antony Samy et al.
In the modern era, chronic kidney failure due to diabetes has spread across the globe. Prunetin (PRU), a component of herbal medicines, has a broad variety of pharmacological activities; these may help to slow the onset of diabetic kidney d...
Stimulatory Anticancer Effect of Resveratrol Mediated by G Protein-Coupled Estrogen Receptor in Colorectal Cancer [0.03%]
白藜醇通過G蛋白耦聯雌激素受體介導的抗結直腸癌作用
Nayun Kim,Junhye Kwon,Ui Sup Shin et al.
Nayun Kim et al.
Colorectal cancer (CRC) is one of the most high-risk cancers; however, it has been suggested that estrogen signaling in CRC could have a protective effect. Therefore, we focused on the function of the G protein-coupled estrogen receptor (GP...
Current Status and Future Trends of Cold Atmospheric Plasma as an Oncotherapy [0.03%]
冷等离子体抗肿瘤研究现状与未来趋势
Xiaofeng Dai,Jiale Wu,Lianghui Lu et al.
Xiaofeng Dai et al.
Cold atmospheric plasma (CAP), a redox modulation tool, is capable of inhibiting a wide spectrum of cancers and has thus been proposed as an emerging onco-therapy. However, with incremental successes consecutively reported on the anticancer...