Effect of Various Pathological Conditions on Nitric Oxide Level and L-Citrulline Uptake in Motor Neuron-Like (NSC-34) Cell Lines [0.03%]
各种病理条件对运动神经元样(NSC-34)细胞系中一氧化氮水平和L-瓜氨酸摄取的影响
Shashi Gautam,Sana Latif,Young-Sook Kang
Shashi Gautam
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder that causes progressive paralysis. L-Citrulline is a non-essential neutral amino acid produced by L-arginine via nitric oxide synthase (NOS). According to previous studies...
Antiproliferative Activity of Piceamycin by Regulating Alpha-Actinin-4 in Gemcitabine-Resistant Pancreatic Cancer Cells [0.03%]
松杉菌素通过调节吉西他滨抗性胰腺癌细胞的Alpha-actinin-4发挥其抗增值作用活性
Jee-Hyung Lee,Jin Ho Choi,Kyung-Min Lee et al.
Jee-Hyung Lee et al.
Although gemcitabine-based regimens are widely used as an effective treatment for pancreatic cancer, acquired resistance to gemcitabine has become an increasingly common problem. Therefore, a novel therapeutic strategy to treat gemcitabine-...
Contribution of HSP90 Cleavage to the Cytotoxic Effect of Suberoylanilide Hydroxamic Acid In Vivo and the Involvement of TXNIP in HSP90 Cleavage [0.03%]
HSP90的裂解对亚甲基水杨酸氢氧化物体内细胞毒性影响的贡献及TXNIP在HSP90裂解中的作用
Sangkyu Park,Dongbum Kim,Haiyoung Jung et al.
Sangkyu Park et al.
Heat shock protein (HSP) 90 is expressed in most living organisms, and several client proteins of HSP90 are necessary for cancer cell survival and growth. Previously, we found that HSP90 was cleaved by histone deacetylase (HDAC) inhibitors ...
Licochalcone C Inhibits the Growth of Human Colorectal Cancer HCT116 Cells Resistant to Oxaliplatin [0.03%]
Licochalcone C抑制奥沙利铂抗性人结肠直肠癌HCT116细胞的生长
Seung-On Lee,Sang Hoon Joo,Jin-Young Lee et al.
Seung-On Lee et al.
Licochalcone C (LCC; PubChem CID:9840805), a chalcone compound originating from the root of Glycyrrhiza inflata, has shown anticancer activity against skin cancer, esophageal squamous cell carcinoma, and oral squamous cell carcinoma. Howeve...
Doxorubicin Attenuates Free Fatty Acid-Induced Lipid Accumulation via Stimulation of p53 in HepG2 Cells [0.03%]
多柔比星通过刺激HepG2细胞中的p53来减轻游离脂肪酸诱导的脂质积聚
Chawon Yun,Sou Hyun Kim,Doyoung Kwon et al.
Chawon Yun et al.
Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive accumulation of fat in the liver, and there is a global increase in its incidence owing to changes in lifestyle and diet. Recent findings suggest that p53 is involved i...
Rosmarinic Acid Inhibits Ultraviolet B-Mediated Oxidative Damage via the AKT/ERK-NRF2-GSH Pathway In Vitro and In Vivo [0.03%]
鼠李糖酸通过AKT / ERK-NRF2-GSH途径抑制紫外B光诱导的氧化损伤(体内和体外)
Mei Jing Piao,Pattage Madushan Dilhara Jayatissa Fernando,Kyoung Ah Kang et al.
Mei Jing Piao et al.
Rosmarinic acid (RA) is a phenolic ester that protects human keratinocytes against oxidative damage induced by ultraviolet B (UVB) exposure, however, the mechanisms underlying its effects remain unclear. This study aimed to elucidate the ce...
Effects of Corticosterone on Beta-Amyloid-Induced Cell Death in SH-SY5Y Cells [0.03%]
皮质酮对SH-SY5Y细胞中β淀粉样蛋白诱导的细胞死亡的影响
Bo Kyeong Do,Jung-Hee Jang,Gyu Hwan Park
Bo Kyeong Do
Alzheimer's disease (AD) is a neurodegenerative disease characterized by neuronal cell death and memory impairment. Corticosterone (CORT) is a glucocorticoid hormone produced by the hypothalamic-pituitary-adrenal axis in response to a stres...
Exploring the Potential of Rosemary Derived Compounds (Rosmarinic and Carnosic Acids) as Cancer Therapeutics: Current Knowledge and Future Perspectives [0.03%]
探索以迷迭香提取物（鼠尾草酸和卡诺西酸）作为癌症治疗药物的潜力：当前知识与未来展望
Fazila Sirajudeen,Lara J Bou Malhab,Yasser Bustanji et al.
Fazila Sirajudeen et al.
Cancer is a global health challenge with high morbidity and mortality rates. However, conventional cancer treatment methods often have severe side effects and limited success rates. In the last decade, extensive research has been conducted ...
Anti-Inflammatory Herbal Extracts and Their Drug Discovery Perspective in Atopic Dermatitis [0.03%]
抗炎药用植物提取物及其在特应性皮炎药物发现方面的前景
Jae-Won Lee,Eun-Nam Kim,Gil-Saeng Jeong
Jae-Won Lee
Atopic dermatitis (AD) is an allergic disorder characterized by skin inflammation. It is well known that the activation of various inflammatory cells and the generation of inflammatory molecules are closely linked to the development of AD. ...
Kyoung Song
Kyoung Song
Cytokines influence the overall cancer immune cycle by triggering tumor antigen expression, antigen presenting, immune cell priming and activation, effector immune cell recruitment and infiltration to cancer, and cancer killing in the tumor...