Endoplasmic Reticulum Stress Activates Hepatic Macrophages through PERK-hnRNPA1 Signaling [0.03%]
内质网应激通过PERK-hnRNPA1信号激活肝巨噬细胞
Ari Kwon,Yun Seok Kim,Jiyoon Kim et al.
Ari Kwon et al.
Endoplasmic reticulum (ER) stress plays a crucial role in liver diseases, affecting various types of hepatic cells. While studies have focused on the link between ER stress and hepatocytes as well as hepatic stellate cells (HSCs), the preci...
Quinic Acid Alleviates Behavior Impairment by Reducing Neuroinflammation and MAPK Activation in LPS-Treated Mice [0.03%]
咖啡酸通过减少LPS处理的小鼠神经炎症和MAPK活化来缓解行为障碍
Yongun Park,Yunn Me Me Paing,Namki Cho et al.
Yongun Park et al.
Compared to other organs, the brain has limited antioxidant defenses. In particular, the hippocampus is the central region for learning and memory and is highly susceptible to oxidative stress. Glial cells are the most abundant cells in the...
Novel Potential Therapeutic Targets in Autosomal Dominant Polycystic Kidney Disease from the Perspective of Cell Polarity and Fibrosis [0.03%]
从细胞极性和纤维化角度探讨常染色体显性多囊肾病的潜在治疗靶点
Yejin Ahn,Jong Hoon Park
Yejin Ahn
Autosomal dominant polycystic kidney disease (ADPKD), a congenital genetic disorder, is a notable contributor to the prevalence of chronic kidney disease worldwide. Despite the absence of a complete cure, ongoing research aims for early dia...
Unlocking the Therapeutic Potential of BCL-2 Associated Protein Family: Exploring BCL-2 Inhibitors in Cancer Therapy [0.03%]
BCL-2家族蛋白的治疗潜力及其抑制剂在癌症治疗中的应用展望
Bisan El Dakkak,Jalal Taneera,Waseem El-Huneidi et al.
Bisan El Dakkak et al.
Apoptosis, programmed cell death pathway, is a vital physiological mechanism that ensures cellular homeostasis and overall cellular well-being. In the context of cancer, where evasion of apoptosis is a hallmark, the overexpression of anti-a...
Cordycepin Enhanced Therapeutic Potential of Gemcitabine against Cholangiocarcinoma via Downregulating Cancer Stem-Like Properties [0.03%]
虫草素通过降低癌症干细胞样特性增强化疗药物吉西他滨治疗胆管癌的潜力
Hong Kyu Lee,Yun-Jung Na,Su-Min Seong et al.
Hong Kyu Lee et al.
Cordycepin, a valuable bioactive component isolated from Cordyceps militaris, has been reported to possess anti-cancer potential and the property to enhance the effects of chemotherapeutic agents in various types of cancers. However, the ab...
Activation of Heme Oxygenase-1 by Mangiferin in Human Retinal Pigment Epithelial Cells Contributes to Blocking Oxidative Damage [0.03%]
芒果苷通过激活人视网膜色素上皮细胞中的血红素氧合酶-1来阻断氧化损伤的作用机制研究
Cheol Park,Hee-Jae Cha,Hyun Hwangbo et al.
Cheol Park et al.
Mangiferin is a kind of natural xanthone glycosides and is known to have various pharmacological activities. However, since the beneficial efficacy of this compound has not been reported in retinal pigment epithelial (RPE) cells, this study...
Ginsenosides Decrease β-Amyloid Production via Potentiating Capacitative Calcium Entry [0.03%]
人参皂苷通过增强容积控制的钙内流而减少β-淀粉样蛋白的生成
Yoon Young Cho,Jeong Hill Park,Jung Hee Lee et al.
Yoon Young Cho et al.
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder characterized by extracellular amyloid plaques composed of amyloid β-peptide (Aβ). Studies have indicated that Ca2+ dysregulation is involved in AD path...
Metabolomic Profiles in Patients with Cervical Cancer Undergoing Cisplatin and Radiation Therapy [0.03%]
接受顺铂联合放疗的宫颈癌患者代谢轮廓分析
Seo-Yeon Choi,Suin Kim,Ji-Young Jeon et al.
Seo-Yeon Choi et al.
This study was aimed to evaluate endogenous metabolic changes before and after cisplatin and radiation therapy in patients with cervical cancer via untargeted metabolomic analysis using plasma samples. A total of 13 cervical cancer patients...
Exploring the Potential of Natural Products as FoxO1 Inhibitors: an In Silico Approach [0.03%]
基于计算的天然产物潜在FOXO1抑制剂研究
Anugya Gupta,Rajesh Haldhar,Vipul Agarwal et al.
Anugya Gupta et al.
FoxO1, a member of the Forkhead transcription factor family subgroup O (FoxO), is expressed in a range of cell types and is crucial for various pathophysiological processes, such as apoptosis and inflammation. While FoxO1's roles in multipl...
Erratum to "Small Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Fusion by Targeting Cavities on Heptad Repeat Trimers" [Biomol Ther 28(4), 311-319 (2020)] [0.03%]
《错误!"中东呼吸综合征冠状病毒融合的小分子抑制剂通过靶向重复率三聚体上的空腔 "[生物分子治疗28 (4), 311-319 (2020)]》
Mahmoud Kandeel,Mizuki Yamamoto,Abdulla Al-Taher et al.
Mahmoud Kandeel et al.
Published Erratum
Biomolecules & therapeutics. 2024 Mar 1;32(2):262-265. DOI:10.4062/biomolther.2024.001 2024