Carnosine and Retinol Synergistically Inhibit UVB-Induced PGE2 Synthesis in Human Keratinocytes through the Up-Regulation of Hyaluronan Synthase 2 [0.03%]
卡尼丁和视黄醇通过上调透明质酸合酶2抑制PGE2的合成
In Guk Park,Sun Hee Jin,Seungchan An et al.
In Guk Park et al.
Skin aging results from complex interactions of intrinsic and extrinsic factors, leading to structural and biochemical changes such as wrinkles and dryness. Ultraviolet (UV) irradiation leads to the degradation of hyaluronic acid (HA) in th...
Inhibitory Action of 1,3,5-Trihydroxybenzene on UVB-Induced NADPH Oxidase 4 through AMPK and JNK Signaling Pathways [0.03%]
对苯三酚通过AMPK和JNK信号通路抑制UVB诱导的NADPH氧化酶4的作用
Chaemoon Lim,Mei Jing Piao,Kyoung Ah Kang et al.
Chaemoon Lim et al.
Specific sensitivity of the skin to ultraviolet B (UVB) rays is one of the mechanisms responsible for widespread skin damage. This study tested whether 1,3,5-trihydroxybenzene (THB), a compound abundant in marine products, might inhibit UVB...
Domperidone, a Dopamine Receptor D2 Antagonist, Induces Apoptosis by Inhibiting the ERK/STAT3-Mediated Pathway in Human Colon Cancer HCT116 Cells [0.03%]
多潘立酮通过抑制ERK/STAT3介导的途径诱导人类结肠癌HCT116细胞凋亡
So Jin Sim,Jeong-Hoon Jang,Joon-Seok Choi et al.
So Jin Sim et al.
Colorectal cancer (CRC) continues to demonstrate high incidence and mortality rates, emphasizing that implementing strategic measures for prevention and treatment is crucial. Recently, the dopamine receptor D2 (DRD2), a G protein-coupled re...
Gut Microbiota Metabolite Messengers in Brain Function and Pathology at a View of Cell Type-Based Receptor and Enzyme Reaction [0.03%]
基于细胞类型的受体和酶反应探讨肠菌代谢产物介导脑功能与病理学的作用机制
Bada Lee,Soo Min Lee,Jae Won Song et al.
Bada Lee et al.
The human gastrointestinal (GI) tract houses a diverse microbial community, known as the gut microbiome comprising bacteria, viruses, fungi, and protozoa. The gut microbiome plays a crucial role in maintaining the body's equilibrium and has...
The Combination of Gefitinib and Acetaminophen Exacerbates Hepatotoxicity via ROS-Mediated Apoptosis [0.03%]
吉非替尼和对乙酰氨基酚通过ROS介导的凋亡协同加重肝毒性
Jiangxin Xu,Xiangliang Huang,Yourong Zhou et al.
Jiangxin Xu et al.
Gefitinib is the well-tolerated first-line treatment of non-small cell lung cancer. As it need for analgesics during oncology treatment, particularly in the context ofthe coronavirus disease, where patients are more susceptible to contract ...
Anti-Inflammatory Activities of (+)-Afzelechin against Lipopolysaccharide-Induced Inflammation [0.03%]
(+)-阿夫zelachin对抗脂多糖诱导的炎症的抗炎作用
In-Chul Lee,Jong-Sup Bae
In-Chul Lee
In this study, we investigated the potential protective effects of (+)-afzelechin (AZC), a natural compound that is derived from Bergenia ligulata, on lipopolysaccharide (LPS)-induced inflammatory responses. AZC is known to have antioxidant...
Structure-Activity Relationship and Functional Evaluation of Cannabinoid Type-1 Receptor [0.03%]
cannabinoid type-1受体构效关系及其功能评价
Shujie Wang,Xinru Tian,Suresh Paudel et al.
Shujie Wang et al.
The type-1 cannabinoid receptor (CB1R) is a potential therapeutic target in several pathological conditions, including neuropsychological disorders and neurodegenerative diseases. Owing to their structural diversity, it is not easy to deriv...
Selonsertib, an ASK1 Inhibitor, Ameliorates Ovalbumin-Induced Allergic Asthma during Challenge and Sensitization Periods [0.03%]
ASK1抑制剂西那替普改善卵清蛋白致敏的小鼠过敏性哮喘症状
So-Young Han,Dong-Soon Im
So-Young Han
Apoptosis signal-regulating kinase 1 (ASK1) is an upstream signaling molecule in oxidative stress-induced responses. Because oxidative stress is involved in asthma pathogenesis, ASK1 gene deficiency was investigated in animal models of alle...
So Won Lee,Hyang-Mi Lee
So Won Lee
Among the therapeutic strategies in cancer immunotherapy-such as immune-modulating antibodies, cancer vaccines, or adoptive T cell transfer-T cells have been an attractive target due to their cytotoxicity toward tumor cells and the tumor an...
Structural Insights into the Interaction of Terpenoids with Streptomyces avermitilis CYP107P2 [0.03%]
茋类化合物茋棓棓树脂素与链霉菌的相互作用的结构洞察
Eunseo Jeong,Vitchan Kim,Changmin Kim et al.
Eunseo Jeong et al.
Streptomyces avermitilis genome includes 33 genes encoding monooxygenation-catalyzing cytochrome P450 enzymes. We investigated the structure of CYP107P2 and its interactions with terpenoid compounds. The recombinant CYP107P2 protein was exp...