Glycogen Phosphorylase Inhibitor Promotes Hair Growth via Protecting from Oxidative-Stress and Regulating Glycogen Breakdown in Human Hair follicles [0.03%]
糖原磷酸化酶抑制剂通过抗氧化及调控糖原分解促进人类毛囊生长脱发的新机制研究
Bomi Park,Daeun Kim,Hairu Zhao et al.
Bomi Park et al.
Hair growth cycles are mainly regulated by human dermal papilla cells (hDPCs) and human outer root sheath cells (hORSCs). Protecting hDPCs from excessive oxidative stress and hORSCs from glycogen phosphorylase (PYGL) is crucial to maintaini...
Coadministration of 6-Shogaol and Levodopa Alleviates Parkinson's Disease-Related Pathology in Mice [0.03%]
6- shoagaol和左旋多巴联合给药可缓解小鼠帕金森病相关病理症状
Jin Hee Kim,Jin Se Kim,In Gyoung Ju et al.
Jin Hee Kim et al.
Parkinson's disease (PD) is a neurodegenerative disease caused by the death of dopaminergic neurons in the nigrostriatal pathway, leading to motor and non-motor dysfunctions, such as depression, olfactory dysfunction, and memory impairment....
Pyronaridine Inhibited MUC5AC Mucin Gene Expression by Regulation of Nuclear Factor Kappa B Signaling Pathway in Human Pulmonary Mucoepidermoid Cells [0.03%]
派那德丁通过调节核因子κB信号途径抑制人肺粘膜细胞中MUC5AC糖蛋白基因的表达
Rajib Hossain,Hyun Jae Lee,Choong Jae Lee
Rajib Hossain
In this study, the potential effects of pyronaridine, an antimalarial agent, on airway MUC5AC mucin gene expression were investigated. The human pulmonary epithelial NCI-H292 cells were pretreated with pyronaridine for 30 min and then stimu...
Decellularized Matrices for the Treatment of Tissue Defects: from Matrix Origin to Immunological Mechanisms [0.03%]
脱细胞基质治疗组织缺陷：从基质来源到免疫机制
Xinyue Wang,Jiqiang Guo,Qing Yu et al.
Xinyue Wang et al.
Decellularized matrix transplantation has emerged as a promising therapeutic approach for repairing tissue defects, with numerous studies assessing its safety and efficacy in both animal models and clinical settings. The host immune respons...
Investigating the Immune-Stimulating Potential of β-Glucan from Aureobasidium pullulans in Cancer Immunotherapy [0.03%]
醭酵母β-葡聚糖的免疫刺激活性及在肿瘤免疫治疗中的应用研究
Jae-Hyeon Jeong,Dae-Joon Kim,Seong-Jin Hong et al.
Jae-Hyeon Jeong et al.
β-glucan, a polysaccharide found in various sources, exhibits unique physicochemical properties, yet its high polymerization limits clinical applications because of its solubility. Addressing this limitation, we introduce PPTEE-glycan, a h...
Aromadendrin Inhibits Lipopolysaccharide-Induced Inflammation in BEAS-2B Cells and Lungs of Mice [0.03%]
aromadendrin抑制脂多糖诱导的BEAS-2B细胞和小鼠肺部炎症作用的研究
Juhyun Lee,Ji-Won Park,Jinseon Choi et al.
Juhyun Lee et al.
Aromadendrin is a phenolic compound with various biological effects such as anti-inflammatory properties. However, its protective effects against acute lung injury (ALI) remain unclear. Therefore, this study aimed to explore the ameliorativ...
Interleukin-1β Signaling Contributes to Cell Cycle Arrest and Apoptotic Cell Death by Leptin via Modulation of AKT and p38MAPK in Hepatocytes [0.03%]
白介素-1β信号通过调节Akt和p38MAPK在肝细胞中促进瘦素诱导的细胞周期阻滞和凋亡
Ananda Baral,Pil-Hoon Park
Ananda Baral
Leptin, an adipose tissue-derived hormone, has exhibited the potent hepatotoxic effects. However, the underlying molecular mechanisms are not fully understood. In this study, we have elucidated the mechanisms by which leptin exerts cytotoxi...
Unraveling Stereochemical Structure-Activity Relationships of Sesquiterpene Lactones for Inhibitory Effects on STAT3 Activation [0.03%]
解开SESQUITERPENE LACTONES的立体化学结构活性关系及其对STAT3激活的抑制作用
Seungchan An,Jaemoo Chun,Joohee Lee et al.
Seungchan An et al.
Sesquiterpene lactones, a class of natural compounds abundant in the Asteraceae family, have gained attention owing to their diverse biological activities, and particularly their anti-proliferative effects on human cancer cells. In this stu...
Gilteritinib Reduces FLT3 Expression in Acute Myeloid Leukemia Cells [0.03%]
吉列替尼可降低急性髓系白血病细胞中的FLT3表达
Thị Lam Thái,Sun-Young Han
Thị Lam Thái
Acute myeloid leukemia (AML) is a genetically diverse and challenging malignancy, with mutations in the FLT3 gene being particularly common and deleterious. Gilteritinib, a potent FLT3 inhibitor, has been approved by the U.S. Food and Drug ...
Loganin Ameliorates Acute Kidney Injury and Restores Tofacitinib Metabolism in Rats: Implications for Renal Protection and Drug Interaction [0.03%]
loganin对急性肾损伤的保护及恢复tofacitinib代谢作用：肾脏保护和药物相互作用的启示
Hyeon Gyeom Choi,So Yeon Park,Sung Hun Bae et al.
Hyeon Gyeom Choi et al.
Tofacitinib, a Janus kinase (JAK) inhibitor used to treat rheumatoid arthritis, is metabolized through hepatic cytochrome P450 (CYP), specifically CYP3A1/2 and CYP2C11. Prolonged administration of rheumatoid arthritis medications is general...