Experimental Mouse Models and Human Lung Organoid Models for Studying Chronic Obstructive Pulmonary Disease [0.03%]
用于慢性阻塞性肺疾病研究的实验小鼠模型和人体肺类器官模型
Young Ae Joe,Min Ju Lee,Hong Seok Choi
Young Ae Joe
Chronic obstructive pulmonary disease (COPD), a leading cause of morbidity and mortality throughout the world, is a highly complicated disease that includes chronic airway inflammation, airway remodeling, emphysema, and mucus hypersecretion...
Atractylodes Lancea and Its Constituent, Atractylodin, Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease via AMPK Activation [0.03%]
苍术及有效成分异阿魏酸通过激活AMPK改善代谢紊乱相关脂肪性肝病
Ga Yeon Song,Sun Myoung Kim,Seungil Back et al.
Ga Yeon Song et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD), which encompasses a spectrum of conditions ranging from simple steatosis to hepatocellular carcinoma, is a growing global health concern associated with insulin resistance. S...
The Anti-Inflammatory Activities of Benzylideneacetophenone Derivatives in LPS Stimulated BV2 Microglia Cells and Mice [0.03%]
苯并烯丙基苯酮衍生物的抗炎活性及其对脂多糖诱导的小胶质细胞BV2和小鼠模型的作用
Mijin Kim,Seungmin Kang,Seikwan Oh
Mijin Kim
A previously reported study highlighted the neuroprotective potential of the novel benzylideneacetophenone derivative, JC3, in mice. In pursuit of compounds with even more robust neuroprotective and anti-inflammatory properties compared to ...
Isoorientin Suppresses Invasion of Breast and Colon Cancer Cells by Inhibition of CXC Chemokine Receptor 4 Expression [0.03%]
异荭草素通过抑制CXC趋化因子受体4的表达来抑制乳腺癌和结肠癌细胞的侵袭能力
Buyun Kim,Byoungduck Park
Buyun Kim
Cancer metastasis still accounts for up to 90% of cancer-related deaths, but the molecular mechanism for metastasis is unclear. Several chemokines and their receptors mediate tumor cell metastasis, particularly through long-term effects tha...
Regulatory Mechanisms Governing the Autophagy-Initiating VPS34 Complex and Its inhibitors [0.03%]
调控自噬起始复合物VPS34的机制及其抑制剂研究进展
Yongook Lee,Nguyen Minh Tuan,Gi Jeong Lee et al.
Yongook Lee et al.
VPS34 is a crucial protein in cells, essential for handling cellular stress through its involvement in autophagy and endocytosis. This protein functions as a Class III phosphatidylinositol 3-kinase, producing phosphatidylinositol 3-phosphat...
Translation Initiation Factor-2S2 (eIF2S2) Contributes to Cervical Carcinogenesis by Inhibiting the TGF-β/SMAD4 Signaling Pathway [0.03%]
translation initiation factor-2s2(eIF2S2)通过抑制TGF-β/smad4信号通路促进宫颈癌发生发展
Juthika Kundu,Hobin Yang,Saerom Moon et al.
Juthika Kundu et al.
The deregulation of protein translational machinery and the oncogenic role of several translation initiation factors have been extensively investigated. This study aimed to investigate the role of eukaryotic translation initiation factor 2S...
Jolkinolide B Ameliorates Liver Inflammation and Lipogenesis by Regulating JAK/STAT3 Pathway [0.03%]
绞股蓝皂苷B通过调节JAK/STAT3信号通路改善肝脏炎症和脂质生成
Hye-Rin Noh,Guoyan Sui,Jin Woo Lee et al.
Hye-Rin Noh et al.
Hepatic dysregulation of lipid metabolism exacerbates inflammation and enhances the progression of metabolic dysfunction-associated steatotic liver disease (MASLD). STAT3 has been linked to lipid metabolism and inflammation. Jolkinolide B (...
Phytotherapeutic BS012 and Its Active Component Ameliorate Allergic Asthma via Inhibition of Th2-Mediated Immune Response and Apoptosis [0.03%]
药用植物BS012及其活性成分通过抑制Th2介导的免疫反应和细胞凋亡改善过敏性哮喘
Siqi Zhang,Joonki Kim,Gakyung Lee et al.
Siqi Zhang et al.
Asthma is a chronic inflammatory disorder of the lungs that results in airway inflammation and narrowing. BS012 is an herbal remedy containing Asarum sieboldii, Platycodon grandiflorum, and Cinnamomum cassia extracts. To elucidate the anti-...
Do Hyun Lee,Hye Jin Jee,Yi-Sook Jung
Do Hyun Lee
Sleep is one of the most essential physiological phenomena for maintaining health. Sleep disturbances, such as insomnia, are often accompanied by psychiatric or physical conditions such as impaired attention, anxiety, and stress. Medication...
Inhibition of Tumoral VISTA to Overcome TKI Resistance via Downregulation of the AKT/mTOR and JAK2/STAT5 Pathways in Chronic Myeloid Leukemia [0.03%]
通过下调慢性粒细胞白血病中的AKT/mTOR和JAK2/STAT5通路抑制肿瘤性VISTA以克服TKI耐药性
Kexin Ai,Mu Chen,Zhao Liang et al.
Kexin Ai et al.
Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment landscape for chronic myeloid leukemia (CML). However, TKI resistance poses a significant challenge, leading to treatment failure and disease progression. Resistance mechan...