Combination of Cannabidiol with Taurine Synergistically Treated Periodontitis in Rats [0.03%]
cannabidiol联合牛磺酸协同治疗大鼠牙周炎
Se Woong Kim,Saroj Kumar Shrestha,Badmaarag-Altai Chuluunbaatar et al.
Se Woong Kim et al.
The active component in cannabis, cannabidiol (CBD), was first isolated from the hemp plant in 1940. Chronic pain, inflammation, migraines, depression, and anxiety have long been treated with CBD. The fundamental mechanisms of CBD's effects...
Glutathione's Role in Liver Metabolism and Hangover Symptom Relief: Dysregulation of Protein S-Glutathionylation and Antioxidant Enzymes [0.03%]
谷胱甘肽在肝脏代谢和宿醉缓解中的作用：蛋白质S-谷胱甘肽化及抗氧化酶失衡
Hwa-Young Lee,Geum-Hwa Lee,Do-Sung Kim et al.
Hwa-Young Lee et al.
Hangovers from alcohol consumption cause symptoms like headaches, nausea, and fatigue, disrupting daily activities and overall well-being. Over time, they can also lead to inflammation and oxidative stress. Effective hangover relief allevia...
Intra-Articular Injection of Stem Cells for the Regeneration of Knee Joint Cartilage: a Therapeutic Option for Knee Osteoarthritis - a Narrative Review [0.03%]
膝关节骨关节炎干细胞关节腔注射软骨再生疗法叙事性回顾性研究
Hyun Jae Lee,Rajib Hossain,Chang-Heon Baek et al.
Hyun Jae Lee et al.
Current approaches to regulating osteoarthritis primarily focus on symptom management; however, these methods often have significant side effects and may not be suitable for long-term care. As an alternative to conventional treatments, inje...
Natural Compounds in Kidney Disease: Therapeutic Potential and Drug Development [0.03%]
肾脏疾病中的天然活性物质：作用机制和药物开发前景分析
Vijayakumar Natesan,Sung-Jin Kim
Vijayakumar Natesan
Diabetic kidney disease (DKD) poses a major global health challenge, affecting millions of individuals and contributing to substantial morbidity and mortality. Traditional treatments have focused primarily on managing symptoms and slowing d...
Tanshinone, a Natural NADPH Oxidase Inhibitor, Mitigates Testosterone-Induced Hair Loss [0.03%]
基于自然的NADPH氧化酶抑制剂丹参酮可通过抑制睾丸素引起的脱发来促进头发生长
Yeo Kyu Hur,Jin Yeong Chae,Min Hye Choi et al.
Yeo Kyu Hur et al.
Previous studies have shown that testosterone activates the GPRC6A-Duox1 axis, resulting in the production of H2O2 which leads to the apoptosis of keratinocytes and ultimately hair loss. Here, we elucidated a molecular mechanism by which th...
Mechanism of Action and Pharmacokinetics of Approved Bispecific Antibodies [0.03%]
已获批双特异性抗体的作用机制和药代动力学
Seong Min Choi,Ju-Hee Lee,Soyeon Ko et al.
Seong Min Choi et al.
Bispecific antibodies represent a significant advancement in therapeutic antibody engineering, offering the ability to simultaneously target two distinct antigens. This dual-targeting capability enhances therapeutic efficacy, especially in ...
Is There such a Thing as Post-Viral Depression?: Implications for Precision Medicine [0.03%]
新冠病毒感染后的抑郁症状：精确医疗的视角及其重要性
Eun-Sook Park,Chan Young Shin,Se Jin Jeon et al.
Eun-Sook Park et al.
Viral infections are increasingly recognized as triggers for depressive disorders, particularly following the SARS-CoV-2 pandemic and the rise of long COVID. Viruses such as Herpes Simplex Virus (HSV), Epstein-Barr Virus (EBV), Cytomegalovi...
Collagen Type VII (COL7A1) as a Longevity Mediator in Caenorhabditis elegans: Anti-Aging Effects on Healthspan Extension and Skin Collagen Synthesis [0.03%]
Ⅶ型胶原（COL7A1）作为秀丽隐杆线虫中的长寿调节因子：健康寿命延长和皮肤胶原蛋白合成的抗衰老作用
Juewon Kim,Hyeryung Kim,Woo-Young Seo et al.
Juewon Kim et al.
Longevity genes and senescence-related signaling proteins are crucial targets in aging research, which aims to enhance the healthy period and quality of life. Identifying these target proteins remains challenging because of the need for pre...
The Multifaceted Role of Epithelial Membrane Protein 2 in Cancer: from Biomarker to Therapeutic Target [0.03%]
上皮膜蛋白2在癌症中的多重作用：从生物标志物到治疗靶点
Ji Yun Jang,Mi Kyung Park,Chang Hoon Lee et al.
Ji Yun Jang et al.
Tetraspanin superfamily proteins not only facilitate the trafficking of specific proteins to distinct plasma membrane domains but also influence cell-to-cell and cell-extracellular matrix interactions. Among these proteins, Epithelial Membr...
Emodin Inhibited MUC5AC Mucin Gene Expression via Affecting EGFR-MAPK-Sp1 Signaling Pathway in Human Airway Epithelial Cells [0.03%]
大黄素通过影响EGFR-MAPK-Sp1信号途径抑制人呼吸道上皮细胞MUC5AC粘蛋白基因表达
Rajib Hossain,Hyun Jae Lee,Chang-Heon Baek et al.
Rajib Hossain et al.
The aim of this study was to evaluate emodin, a natural trihydroxyanthraquinone compound found in the roots and barks of several plants including rhubarb and buckthorn, might attenuate epidermal growth factor (EGF)-induced airway MUC5AC muc...