The SIRT6 Activator MDL-800 Inhibits PPARα and Fatty acid Oxidation-Related Gene Expression in Hepatocytes [0.03%]
SIRT6激活剂MDL-800抑制PPARα及肝细胞脂肪酸氧化相关基因表达
Yeonsoo Kim,Hyeokjin Lim,Ye Eun Cho et al.
Yeonsoo Kim et al.
A histone deacetylase SIRT6 regulates the transcription of various genes involved in lipid metabolism. Fatty acid (FA) oxidation plays a pivotal role in maintaining hepatic lipid homeostasis, and its dysregulation significantly contributes ...
Dual Disruption of DNA Repair by a Novel CHK2 Inhibitor, ART-446, and Olaparib is a Promising Strategy for Triple-Negative Breast Cancer Therapy [0.03%]
CHK2抑制剂ART-446与奥拉帕利联合治疗三阴性乳腺癌的协同策略：针对DNA修复的新双联阻断方法研究
Hong-Jun Kang,Young-Woo Kang,Ha-Young Lee et al.
Hong-Jun Kang et al.
Triple-negative breast cancer (TNBC) is an aggressive cancer subtype lacking targeted therapies and is characterized by high recurrence rates and poor prognosis. Recent advances in targeting DNA damage response (DDR) pathways using poly (AD...
1,3,5-Tricaffeoylquinic Acid from Ipomoea batatas Vines Induced Ovarian Cancer Cell Apoptosis and Inhibited Endothelial Tube Formation [0.03%]
番石榴叶中1,3,5-三咖啡酸奎尼酸诱导卵巢癌细胞凋亡及抑制内皮管形成作用研究
Dahae Lee,Jaekyoung Kim,Soyoon Baek et al.
Dahae Lee et al.
Ovarian cancer usually metastasizes from the ovary to adjacent organs through direct invasion with blood vessels formed by endothelial cells. Targeting apoptosis of ovarian cancer and angiogenesis is promising for anticancer therapy. Leaves...
Stress Accelerates Depressive-Like Behavior through Increase of SPNS2 Expression in Tg2576 Mice [0.03%]
应激通过增加Tg2576小鼠SPNS2表达促进类似抑郁行为发生
Seung Sik Yoo,Yuri Kim,Dong Won Lee et al.
Seung Sik Yoo et al.
To investigate the relationship between depression and AD, water avoidance stress (WAS) was induced for 10 days in both Tg2576 mice and wild-type (WT) mice. After WAS, memory function and depressive-like behavior were investigated in Tg2576...
Cynaropicrin Induces Reactive Oxygen Species-Dependent Paraptosis-Like Cell Death in Human Liver Cancer Cells [0.03%]
除活性氧依赖的类似芽肿反应的细胞死亡诱导人类肝癌细胞
Min Yeong Kim,Hee-Jae Cha,Su Hyun Hong et al.
Min Yeong Kim et al.
Cynaropicrin, a sesquiterpene lactone found in artichoke leaves exerts diverse pharmacological effects. This study investigated whether cynaropicrin has a paraptosis-like cell death effect in human hepatocellular carcinoma Hep3B cells in ad...
Andrographolide as a Multi-Target Therapeutic Agent in Diabetic Nephropathy: Insights into STAT3/PI3K/Akt Pathway Modulation [0.03%]
andrographolide作为治疗糖尿病肾病的多靶点药物：STAT3/PI3K/Akt途径调节的新见解
Yuan Yin,Jing He,Yu Fang et al.
Yuan Yin et al.
Diabetic nephropathy (DN) remains a leading cause of end-stage renal disease (ESRD), driven by chronic inflammation, oxidative stress, and apoptosis. Current therapies targeting glycemic and blood pressure control fail to address the underl...
Microplastics Accumulation Induces Kynurenine-Derived Neurotoxicity in Cerebral Organoids and Mouse Brain [0.03%]
微塑料蓄积诱导类器官和小鼠脑内犬尿氨酸途径神经毒性
Sung Bum Park,Jeong Hyeon Jo,Seong Soon Kim et al.
Sung Bum Park et al.
Microplastics are pervasive environmental pollutants with potential adverse effects on human health, particularly concerning neurotoxicity. This study investigates the accumulation and neurotoxic effects of MP in cerebral organoids and mous...
Erratum to "Potential Role of Dietary Salmon Nasal Cartilage Proteoglycan on UVB-Induced Photoaged Skin" [Biomol Ther 32(2), 249-260 (2024)] [0.03%]
《关于“膳食三文鱼鼻软骨蛋白多糖对UVB诱导的光老化皮肤潜在作用”的勘误》[Biomol Ther 32(2), 249-260 (2024)]
Hae Ran Lee,Seong-Min Hong,Kyohee Cho et al.
Hae Ran Lee et al.
Artesunate Inhibits the Proliferation and Migration of Cutaneous Squamous Cell Carcinoma by Regulating the SLC7A11-GPX4 Pathway via the p300-p53 Axis [0.03%]
青蒿琥酯通过p300-p53轴调控SLC7A11-GPX4通路抑制皮肤鳞状细胞癌的增殖和迁移
Xinyan Huang,Wenxi Wang,Songzhao Zhang et al.
Xinyan Huang et al.
The incidence of cutaneous squamous cell carcinoma (CSCC) is increasing rapidly. This study discussed the effects of artesunate (ART) on CSCC cell proliferation and migration via the solute carrier family 7 member 11 (SLC7A11)-glutathione p...
Quercetin-3-Methyl Ether Induces Early Apoptosis to Overcome HRV1B Immune Evasion, Suppress Viral Replication, and Mitigate Inflammatory Pathogenesis [0.03%]
石蒜碱-3-甲基醚通过诱导早期凋亡来克服HRV1B免疫逃逸，抑制病毒复制并减轻炎症发病机制
Jae-Hyoung Song,Seo-Hyeon Mun,Sunil Mishra et al.
Jae-Hyoung Song et al.
Human rhinovirus (HRV) causes the common cold and exacerbates chronic respiratory diseases, such as asthma and chronic obstructive pulmonary disease. Despite its significant impact on public health, there are currently no approved vaccines ...