2',4',6'-Trimethoxyacetophenone Isolated from Lycoris sanguinea Ameliorates Memory Impairment in Methylglyoxal-Induced Depressive Amnesia Mouse Model [0.03%]
从红珠兰中分离的2',4',6'-三甲氧基乙酰苯酮可改善甲基糖醛诱导的抑郁健忘小鼠模型的记忆障碍
Eun Ji Ko,Seong-Min Hong,Hoseong Hwang et al.
Eun Ji Ko et al.
Depressive amnesia, involving memory impairment and mood dysregulation, frequently co-occurs with depression and neurodegenerative diseases. Methylglyoxal (MGO), a reactive glycolytic byproduct, contributes to depressive-like behaviors and ...
Toxoplasma gondii GRA16 Suppresses Aerobic Glycolysis by Downregulating c-Myc and TERT Expressions in Colorectal Cancer Cells [0.03%]
GRA16通过下调c-Myc和TERT的表达抑制肠道肿瘤细胞的糖酵解
Ji-Eun Lee,Seung-Hwan Seo,Do-Won Ham et al.
Ji-Eun Lee et al.
Despite its relatively low adenosine triphosphate (ATP) production efficiency, cancer cells reprogram their metabolism to utilize aerobic glycolysis for rapid proliferation. This "Warburg effect" not only provides biosynthetic precursors bu...
Anticancer Potential of Myricetin against Huh7- and Hep3B-Derived Liver Cancer Stem Cells through the Regulation of Apoptosis, Autophagy, and Stemness [0.03%]
芦丁通过调控凋亡、自噬和干性抑制肝癌干细胞的抗肿瘤潜力
Mikyoung Kwon,Hye Jin Jung
Mikyoung Kwon
Liver cancer stem cells (LCSCs) play a significant role in the development, metastasis, treatment resistance, and recurrence of hepatocellular carcinoma (HCC). Targeting LCSCs offers a novel strategy to overcome treatment resistance in HCC....
RNA Therapeutics: Focus on Antisense Oligonucleotides in the Nervous System [0.03%]
核酸治疗：神经系统的反义寡核苷酸疗法:focus
Betül Ertural,Büşra Nur Çiçek,Işıl Aksan Kurnaz
Betül Ertural
RNA therapeutics present a disruptive technology that has changed the drug discovery and manufacturing landscape, which established itself more prominently upon the recent COVID-19 pandemic. RNA therapeutics encompass diverse molecules like...
Amelioration of Carrageenan/Kaolin-Induced Arthritis by Benzylideneacetophenone Derivatives in Rats [0.03%]
茋衍生物通过抑制NF-κB信号通路改善痛风性关节炎小鼠的关节炎症反应
Seungmin Kang,Mijin Kim,Hyun-Su Lee et al.
Seungmin Kang et al.
This study was done to evaluate the inhibitory effects of benzylideneacetophenone derivatives (JCII) on rheumatoid arthritis (RA). This was done by using carrageenan/kaolin-induced arthritis in rats and human RA fibroblast-like synoviocytes...
Curcumenol Inhibits Mast Cells Activation in Ovalbumin-Induced Anaphylaxis Model Mice through Modulation of the Fc Epsilon Receptor I Signaling Pathway [0.03%]
姜黄素醇通过调节Fc epsilon受体I信号转导途径抑制卵清蛋白诱导的大鼠肥大细胞活化
Yun-Mi Kang,Ki-Shuk Shim,Sung-Wook Chae et al.
Yun-Mi Kang et al.
Curcumenol, a sesquiterpene isolated from Curcuma zedoaria, has a variety of therapeutic effects, such as neuroprotective, antitumor and hepatoprotective effects. This study elucidates whether curcumenol can inhibit ovalbumin (OVA)-induced ...
Triggering Mechanisms of Hepatocyte Repopulation during liver Regeneration [0.03%]
肝再生过程中触发肝细胞再填充的机制
Eui Jin Lee,Na Young Lee,Myeung Gi Choi et al.
Eui Jin Lee et al.
Liver regeneration is a complex process involving hepatocyte proliferation and differentiation, which is essential for restoring liver function after liver injury. Hepatocyte repopulation plays a central role in this regenerative process, a...
Association between Prenatal Particulate Matter (PM) Exposure and Neuropsychiatric Disorders Development [0.03%]
孕期颗粒物(PM)暴露与神经精神疾病发病风险的关联研究
Ho Jung Bae,Tamanna Jahan Mony,Se Jin Park
Ho Jung Bae
This comprehensive review explores the relationship between prenatal exposure to particulate matter (PM) air pollution and the development of various neuropsychiatric disorders in offspring. Air pollution, specifically PM, is a global healt...
Niclosamide Alleviated Skin Inflammation and Restored the Balance between Effector and Regulatory T Cells in Skin [0.03%]
尼克地尔缓解皮肤炎症并恢复皮肤中效应T细胞和调节性T细胞的比例
Bo Mi Kang,Eunyoung Seo,Jung Min Ahn et al.
Bo Mi Kang et al.
Niclosamide is an oral anthelmintic agent and was reported to also have anti-inflammatory effects by suppressing STAT3 signaling pathways. In this study, we investigated the effect of niclosamide on skin inflammatory diseases to determine i...
OZ-001 Suppresses the Growth of Triple-Negative Breast Cancer and Pancreatic Cancer by Targeting STAT3 Phosphorylation and the Calcium Signaling Pathway [0.03%]
OZ-001通过靶向STAT3磷酸化和钙信号通路抑制三阴性乳腺癌和胰腺癌的生长
Jisun Kim,Hyun-Kyoung Kim,SunHye Lee et al.
Jisun Kim et al.
Triple-negative breast cancer (TNBC) and pancreatic ductal adenocarcinoma (PDAC) are aggressive malignancies characterized by uncontrolled tumor growth, high recurrence rates, and resistance to chemotherapy. OZ-001 is a small molecule with ...