Melatonin Prevents the Progression of MASLD via Inhibiting FFAs-Induced Ferroptosis through KEAP1/NRF2/HO-1 Pathway [0.03%]
褪黑素通过KEAP1/NRF2/HO-1信号通路抑制FFAs诱导的铁死亡从而阻止MASLD进展
Shuojiao Li,Peng Rao,Wenxian Yu et al.
Shuojiao Li et al.
The accumulation of free fatty acids in hepatocytes is a key characteristic of metabolic dysfunction-associated steatotic liver disease (MASLD), which leads to lipid peroxidation and ultimately results in ferroptosis. Currently, there is an...
Pathophysiological Insights and Clinical Management Strategies for Interstitial Lung Diseases [0.03%]
间质性肺疾病的病理生理学见解和临床管理策略
Lin Tian,Yun Wang,Wenlong Qi et al.
Lin Tian et al.
Interstitial lung disease (ILD) represents a heterogeneous group of diseases in which inflammation and/or fibrosis in the pulmonary interstitium results in an impaired gas exchange, difficulties in breathing, and reduced quality of daily li...
Control of Overly Secreted Tryptophanyl tRNA Synthetase Attenuates Sepsis Severity in a Porcine Model [0.03%]
调控过量分泌的色氨酰-tRNA合成酶可减轻猪脓毒症模型的发病严重程度
Yoon Tae Kim,Geunyeol Jeong,Yihyo Kim et al.
Yoon Tae Kim et al.
Sepsis is a leading cause of mortality in hospitals with a lack of reliable biomarkers and specialized therapeutics. Recently, highly secreted tryptophanyl-tRNA synthetase 1 (WARS1), an endogenous ligand for Toll-like receptor (TLR) 2 and T...
Small-Molecule-Induced Protein Polymerization: Mechanisms and Therapeutic Implications [0.03%]
小分子诱导蛋白质聚合的机制及药物研发意义
Young-Sool Hah,Sun-Young Han
Young-Sool Hah
Small molecules that induce protein polymerization represent an emerging class of compounds with diverse therapeutic potential. This review provides a comprehensive overview of five such molecules: arsenic trioxide (As2O3), BI-3802, NVS-STG...
Chitinase-3-Like Protein 1 as a Therapeutic Target for Inflammatory Diseases [0.03%]
炎性疾病治疗靶点丁酸盐诱导的抗菌蛋白Chtlp1
Sun Mi Gu,Tae Hun Kim,Jeong Ho Park et al.
Sun Mi Gu et al.
Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein involved in macrophage polarization, apoptosis, and inflammation, and carcinogenesis. The expression of CHI3L1 is significantly increased in various inflammatory and immunologic...
Zeynep Nur Cinviz,Elisabetta Moroni,Ozge Sensoy et al.
Zeynep Nur Cinviz et al.
Out of at least 20,000 human proteins fewer than 700 are targeted by drugs. Arrestins regulate G protein-coupled receptors, the largest family of signaling proteins in animals, as well as many receptor-independent signaling pathways. Humans...
An Endolichenic Fungi-Derived Fatty Acid, cis-10-Nonadecenoic acid, Suppresses Colorectal Cancer Stemness [0.03%]
一种内生真菌衍生脂肪酸cis-10-非acosahexaenoic酸可抑制结直肠癌干细胞属性
Mücahit Varlı,Eun-Young Lee,So-Yeon Park et al.
Mücahit Varlı et al.
Endolichenic fungi (ELF), symbionts of lichens, have been reported to produce diverse bioactive secondary metabolites with promising pharmaceutical potential. In this study, we isolated and identified an ELF, EL001668 (KACC 83020BP), from C...
Inhibitory Effect of a Novel Non-Steroidal AMPamide on Inflammation and Sebogenesis by Suppressing TLR4 and TLR6-Mediated Signaling Pathway [0.03%]
一种新型非甾体AMP胺抑制炎症和皮脂生成的作用及其对TLR4和TLR6介导的信号通路的抑制作用
Myo Hyeon Park,Yu Ra Jung,Eun Bi Choi et al.
Myo Hyeon Park et al.
Seborrheic dermatitis (SD) is a chronic inflammatory skin disorder that primarily affects areas with increased sebaceous gland activity, and is characterized by erythematous scaly lesions. Malassezia utilizes sebum lipids to produce free fa...
MST3 Regulates AMPK and YAP-Hippo Signaling in Cell Models Relevant to Renal Fibrosis [0.03%]
MST3通过调控AMPK和YAP-Hippo信号通路影响肾纤维化细胞模型
Chee-Hong Chan,Te-Jung Lu,Bo-Ying Bao et al.
Chee-Hong Chan et al.
YAP is a transcription cofactor in the Hippo pathway that interacts with the TEAD family of transcription factors in the nucleus to promote CTGF expression and stimulate cell growth. YAP hyperactivation is frequently observed in fibrotic di...
Identification of Autophagy-Related Prognostic Signature for Glioblastoma Standard Therapy [0.03%]
胶质母细胞瘤标准治疗的自噬相关预后标志物的鉴定
Min Ju Lee,Hong Seok Choi,Eun Jeong Min et al.
Min Ju Lee et al.
Glioblastoma is an aggressive brain tumor with poor prognosis and survival. Autophagy is induced in tumor cells under stress conditions such as treatment with chemotherapeutic agents and radiotherapy (RT), causing resistance to therapy. Thu...