12-O-Tetradecanoylphorbol-13-Acetate Induces Keratin 8 Phosphorylation and Reorganization via Expression of Transglutaminase-2 [0.03%]
佛波醇十二酸脂诱导移植物抗宿主病小鼠上皮细胞角蛋白8的磷酸化和重新排列涉及转谷氨酰胺酶-2的表达
Eun Ji Lee,Mi Kyung Park,Hyun Ji Kim et al.
Eun Ji Lee et al.
The stiffness of cancer cells is attributable to intermediate filaments such as keratin. Perinuclear reorganization via phosphorylation of specific serine residue in keratin is implicated in the deformability of metastatic cancer cells incl...
Vesicular Stomatitis Virus G Glycoprotein and ATRA Enhanced Bystander Killing of Chemoresistant Leukemic Cells by Herpes Simplex Virus Thymidine Kinase/Ganciclovir [0.03%]
水泡性口炎病毒G糖蛋白和ATRA增强单纯疱疹病毒胸苷激酶/甘昔洛韦介导的化学耐药白血病细胞旁观者杀伤作用
Chenxi Hu,Zheng Chen,Wenjun Zhao et al.
Chenxi Hu et al.
Refractoriness of acute myeloid leukemia (AML) cells to chemotherapeutics represents a major clinical barrier. Suicide gene therapy for cancer has been attractive but with limited clinical efficacy. In this study, we investigated the potent...
Enhanced Anti-Cancer Effect of Snake Venom Activated NK Cells on Lung Cancer Cells by Inactivation of NF-κB [0.03%]
通过抑制NF-κB激活的蛇毒NK细胞对肺癌细胞的增强抗癌症效应
Pushpa Saranya Kollipara,Do Hee Won,Chul Ju Hwang et al.
Pushpa Saranya Kollipara et al.
In the present study, we investigated anti-cancer effect of snake venom activated NK cells (NK-92MI) in lung cancer cell lines. We used snake venom (4 μg/ml) treated NK-92MI cells to co-culture with lung cancer cells. There was a further d...
The Inhibitory Effect of Apigenin on the Agonist-Induced Regulation of Vascular Contractility via Calcium Desensitization-Related Pathways [0.03%]
芹菜素通过脱敏相关途径抑制激动剂引起的血管收缩调节作用
Hyun Dong Je,Hyeong-Dong Kim,Hyen-Oh La
Hyun Dong Je
Apigenin, a natural flavonoid found in a variety of vegetables and fruits, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of apigenin on vascular smooth muscle contractilit...
Conformation and Linkage Studies of Specific Oligosaccharides Related to H1N1, H5N1, and Human Flu for Developing the Second Tamiflu [0.03%]
与H1N1、H5N1和人类流感有关的特异性寡糖的构象及连接研究，用于开发第二个达菲药效分子
Eunsun Yoo
Eunsun Yoo
The interaction between viral HA (hemagglutinin) and oligosaccharide of the host plays an important role in the infection and transmission of avian and human flu viruses. Until now, this interaction has been classified by sialyl(α2-3) or s...
Takayuki Sassa,Akio Kihara
Takayuki Sassa
Fatty acids (FAs) are highly diverse in terms of carbon (C) chain-length and number of double bonds. FAs with C>20 are called very long-chain fatty acids (VLCFAs). VLCFAs are found not only as constituents of cellular lipids such as sphingo...
Formulation and evaluation of irinotecan suppository for rectal administration [0.03%]
依立替康肛用栓剂的处方和评价研究
Haiyang Feng,Yuping Zhu,Dechuan Li
Haiyang Feng
Irinotecan suppository was prepared using the moulding method with a homogeneous blend. A sensitive and specific fluorescence method was developed and validated for the determination of irinotecan in plasma using HPLC. The pharmacokinetics ...
Enhanced In Vitro Skin Deposition Properties of Retinyl Palmitate through Its Stabilization by Pectin [0.03%]
通过果胶稳定化提高视黄醇棕榈酸酯的体外皮肤沉积性能
Dong-Churl Suh,Yeongseok Kim,Hyeongmin Kim et al.
Dong-Churl Suh et al.
The purpose of this study was to examine the effect of stabilization of retinyl palmitate (RP) on its skin permeation and distribution profiles. Skin permeation and distribution study were performed using Franz diffusion cells along with ra...
Identification of p-glycoprotein and transport mechanism of Paclitaxel in syncytiotrophoblast cells [0.03%]
人合胞滋养细胞中P-糖蛋白的鉴定及紫杉醇的转运机制研究
Na-Young Lee,Ha-Eun Lee,Young-Sook Kang
Na-Young Lee
When chemotherapy is administered during pregnancy, it is important to consider the fetus chemotherapy exposure, because it may lead to fetal consequences. Paclitaxel has become widely used in the metastatic and adjuvant settings for woman ...
Inhibition of Proinflammatory Cytokine Generation in Lung Inflammation by the Leaves of Perilla frutescens and Its Constituents [0.03%]
紫苏叶及其成分抑制肺部炎症中促炎细胞因子的生成
Hun Jai Lim,Kyeong Wan Woo,Kang Ro Lee et al.
Hun Jai Lim et al.
This study was designed to find some potential natural products and/or constituents inhibiting proinflammatory cytokine generation in lung inflammation, since cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) are ...