Aberrantly High Expression of Steroid Receptor Coactivator-1 Drives Lung Cancer Growth and Metastasis by Enhancing Cancer Stemness [0.03%]
异常高水平的类固醇受体共激活因子-1通过增强癌症干细胞特性来驱动肺癌生长和转移
Jinjin Pan,Haoran Zhou,Liang Liu et al.
Jinjin Pan et al.
Steroid receptor coactivator-1 (SRC-1) is documented in various cancers and primarily mediates tumor growth and metastasis. Nevertheless, the specific effects and underlying mechanisms of SRC-1 in lung cancer have not been fully explored. T...
Dietary Potassium Synergistically Enhances Anti-Obesity Efficacy of Garcinia Cambogia Complex in High-Fat Diet-Induced Obese Mice [0.03%]
膳食钾协同增强番荔枝果皮提取物对高脂诱导的肥胖小鼠的减肥功效
Eunji Park,Sehan Kwak,Ayoung Lim et al.
Eunji Park et al.
Obesity is a global health problem associated with several metabolic disorders. Conventional dietary supplements such as Garcinia cambogia, catechin, and conjugated linoleic acid (GC complex) are widely used for weight loss but raise concer...
IFI16 Enhances Chemosensitivity of Breast Cancer Cells by Inhibiting DNA Damage Response [0.03%]
IFI16通过抑制DNA损伤修复增强乳腺癌细胞的化疗敏感性
Na-Lee Ka,Ga Young Lim,Seung-Su Kim et al.
Na-Lee Ka et al.
Many chemotherapeutic agents exert their cytotoxic effects primarily by inducing DNA damage. In response to DNA damage, cells activate a signaling cascade known as DNA damage response (DDR) to repair the damage and promote cell survival. Ac...
Transforming Pain Management: Suzetrigine, a Novel Non-Opioid Analgesic [0.03%]
从疼痛管理到苏泽曲米定：新型非阿片类镇痛药
Maha AlDoughaim,Nada AlSuhebany,Mohammed AlZahrani et al.
Maha AlDoughaim et al.
Suzetrigine is a novel non-opioid analgesic that selectively inhibits the Nav1.8 sodium channel, which plays a key role in peripheral pain signaling. By blocking action potential propagation in nociceptors, it effectively reduces pain witho...
Brazilein Impedes IKK Activation by Disrupting RIPK1 Polyubiquitination, Increasing Apoptotic Susceptibility in Cells with Constitutively Active NF-κ [0.03%]
巴西辛通过干扰RIPK1多泛素化阻碍IKK活化，增加具有组成型激活NF-κ细胞的凋亡敏感性
Kyeong Ah Park,Hee Sun Byun,Jaehee Ha et al.
Kyeong Ah Park et al.
Ubiquitination of RIPK1 serves as a critical regulatory switch in determining the outcome of prosurvival NF-κB signaling by linking the TNFR1 signaling complex to upstream IKK activation. Therefore, identifying bioactive compounds that mod...
trans-Resveratrol and Hesperidin Supplementation with Treadmill Exercise Alleviates Methylglyoxal-Induced Skeletal Muscle Dysfunction [0.03%]
自创的甲基糖醛模型小鼠中白藜芦醇和橙皮素补充剂结合跑步运动可缓解骨骼肌功能障碍
Jinho Park,Seong-Min Hong,Jiyoun Kim et al.
Jinho Park et al.
Methylglyoxal (MGO), a reactive glycolytic byproduct, contributes to skeletal muscle atrophy by promoting oxidative stress, inflammation, and protein degradation. This study investigated the therapeutic potential of trans-resveratrol and he...
Xylene Impairs Neuronal Development by Dysregulating Calcium Homeostasis and Neuronal Activity in Developing Hippocampal Neurons [0.03%]
间苯二酚通过干扰发育中的海马神经元内钙稳态和神经活动而损害神经元的生长发育
Yunkyung Eom,Sung Hoon Lee
Yunkyung Eom
Xylene is an aromatic hydrocarbon widely used as a solvent and emitted from numerous commercial products in industrial or indoor settings. Epidemiological studies of occupational exposure indicate that xylene primarily targets the central n...
Understanding Tumor Dormancy: from Experimental Models to Mechanisms and Therapeutic Strategies [0.03%]
理解肿瘤休眠：从实验模型到机制和治疗策略
Jaebeom Cho
Jaebeom Cho
Tumor dormancy represents a clinically significant but poorly understood state in which disseminated cancer cells persist in a quiescent, non-proliferative state, evading conventional therapies and driving late relapse. This review summariz...
Taxifolin Regulates the Gene Expression of MUC5AC Mucin via Affecting IκBα/NF-κB p65 Signaling in Human Airway Epithelial Cells [0.03%]
染料木isosflavone通过影响IκBα/NF-κB p65信号通路调节人呼吸道上皮细胞中MUC5AC粘蛋白基因的表达
Rajib Hossain,Md Solayman Hossain,Hyun Jae Lee et al.
Rajib Hossain et al.
In this study, we explored the effects of taxifolin, a flavonoid compound, on the expression of the MUC5AC mucin gene in airway epithelial cells. Human pulmonary epithelial NCI-H292 cells were pretreated with taxifolin for 30 min prior to s...
Atopic Dermatitis Management: from Conventional Therapies to Biomarker-Driven Treatment Approaches [0.03%]
从传统疗法到生物标志物驱动的治疗手段：特应性皮炎管理方案的新趋势
Hye Won Lee,Yun Jin Ju,Seeun Choi et al.
Hye Won Lee et al.
Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder characterized by pruritus, skin barrier dysfunction, and immune dysregulation. It significantly impacts the quality of life and increases the risk of infections, sleep...